Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
- CAS No.
- 656235-44-8
- Chemical Name:
- Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
- Synonyms
- Boronic acid, (2-cyano-6-fluorophenyl)-;2-Cyano-6-fluorophenylboronic acid 95+%;Boronic acid, B-(2-cyano-6-fluorophenyl)-;Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
- CBNumber:
- CB91065223
- Molecular Formula:
- C7H5BFNO2
- Molecular Weight:
- 164.93
- MDL Number:
- MFCD09033623
- MOL File:
- 656235-44-8.mol
- MSDS File:
- SDS
| Boiling point | 367.7±52.0 °C(Predicted) |
|---|---|
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 7.77±0.58(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C7H5BFNO2/c9-6-3-1-2-5(4-10)7(6)8(11)12/h1-3,11-12H |
| InChIKey | PPLSIVNRHUSMMC-UHFFFAOYSA-N |
| SMILES | B(C1=C(F)C=CC=C1C#N)(O)O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2931900090 |
Boronic acid, (2-cyano-6-fluorophenyl)- (9CI) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC412336 | 2-Cyano-6-fluorophenylboronic acid >98% | 656235-44-8 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC412336 | 2-Cyano-6-fluorophenylboronic acid >98% | 656235-44-8 | 1g | $25 | 2026-06-04 | Buy |
| Apolloscientific | PC412336 | 2-Cyano-6-fluorophenylboronic acid >98% | 656235-44-8 | 5g | $79 | 2026-06-04 | Buy |
| Apolloscientific | PC412336 | 2-Cyano-6-fluorophenylboronic acid >98% | 656235-44-8 | 25g | $309 | 2026-06-04 | Buy |
| Apolloscientific | PC412336 | 2-Cyano-6-fluorophenylboronic acid >98% | 656235-44-8 | 100g | $1207 | 2026-06-04 | Buy |
Boronic acid, (2-cyano-6-fluorophenyl)- (9CI) Chemical Properties, Uses, Production
Uses
2-Cyano-6-fluorophenylboronic acid
Synthesis
403-54-3
656235-44-8
General procedure for the synthesis of 2-cyano-6-fluorophenylboronic acid from 3-fluorobenzonitrile: To a 500 mL three-necked round-bottomed flask equipped with a magnetic stirring bar, a dosing funnel, and a nitrogen inlet, under nitrogen protection, were added 3-fluorobenzonitrile (10.0 g, 82.56 mmol), triisopropyl borate (28.5 mL, 23.3 g, 123.84 mmol), and 100 mL anhydrous THF.The reaction mixture was cooled to -50 °C and a THF/hexane solution of LDA (86.7 mmol, freshly prepared from 8.77 g of diisopropylamine in 20 mL of THF and 54.2 mL of 1.6 M n-BuLi in hexane) was added dropwise over a period of 1 hour. The reaction mixture was slowly warmed to -5 °C and stirred at this temperature for 30 min. Subsequently, 70 mL of 5N HCl aqueous solution and 50 mL of MTBE were added and stirred for 30 min at room temperature. The reaction mixture was extracted with MTBE (4 x 100 mL), the organic phases were combined, washed with brine (2 x 100 mL), concentrated under reduced pressure, controlled to a temperature lower than 20 °C, and finally dried in vacuo at room temperature to give 12.16 g (89% yield) of 2-cyano-6-fluorophenylboronic acid as a white solid.LCMS m/z (M+H)+: 165.8. 1H NMR ( 300 MHz, DMSO-d6): δ 8.92 (2H), 7.65 (1H), 7.57 (1H), 7.49 (1H).
References
[1] Patent: WO2006/51410, 2006, A1. Location in patent: Page/Page column 44
[2] Journal of Organic Chemistry, 2005, vol. 70, # 15, p. 5938 - 5945
[3] Journal of Organic Chemistry, 2004, vol. 69, # 2, p. 566 - 569
Boronic acid, (2-cyano-6-fluorophenyl)- (9CI) Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Boloko Biotechnology Co., LTD | 13757158499; 13757158499 | bolokobiotech@qq.com | China | 4877 | 58 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai ShiXian Chemical Technology Co., Ltd. | 13764359345 | 990877971@qq.com | China | 1921 | 50 |
| Shanghai Rong Lin Medical Technology Co., Ltd. | 18602194589 | lincy-110@163.com | China | 873 | 58 |
View Latest Price from Boronic acid, (2-cyano-6-fluorophenyl)- (9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
656235-44-8
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co | |
 |
2019-12-31 | Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
656235-44-8
|
1g | 95%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. | ||
 |
2019-12-31 | Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
656235-44-8
|
1g | 95%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. |
-
- Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
656235-44-8
- $1.00
- 99%
- Career Henan Chemical Co
-
- Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
656235-44-8
- $0.00
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
-
- Boronic acid, (2-cyano-6-fluorophenyl)- (9CI)
656235-44-8
- $0.00
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
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