ChemicalBook >> CAS DataBase List >>Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI)
Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI)
- CAS No.
- 67475-55-2
- Chemical Name:
- Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI)
- Synonyms
- 7475-55-2;4-(Chlorosulphonyl)-2-fluoroanisole;Benzenesulfonyl chloride, 3-fluoro-4-methoxy-;3-Fluoro-4-methoxybenzenesulfonyl chloride 97%;Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI);3-fluoro-4-methoxybenzenesulfonyl chloride(SALTDATA: FREE)
- CBNumber:
- CB91068567
- Molecular Formula:
- C7H6ClFO3S
- Molecular Weight:
- 224.64
- MDL Number:
- MFCD02091380
- MOL File:
- 67475-55-2.mol
- MSDS File:
- SDS
Last updated:2026-06-04 16:00:12
| Melting point | 77-81 °C |
|---|---|
| Boiling point | 314.9±22.0 °C(Predicted) |
| Density | 1.455±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| color | White |
| Sensitive | Moisture Sensitive |
| InChI | 1S/C7H6ClFO3S/c1-12-7-3-2-5(4-6(7)9)13(8,10)11/h2-4H,1H3 |
| InChIKey | QIVDOYCKCLEKPL-UHFFFAOYSA-N |
| SMILES | COc1ccc(cc1F)S(Cl)(=O)=O |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 8 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29049090 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| Limited Quantities | 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI) price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 700983 | 3-Fluoro-4-methoxybenzenesulfonyl chloride 97% | 67475-55-2 | 1g | $39.5 | 2023-01-07 | Buy |
| Apolloscientific | PC5547 | 3-Fluoro-4-methoxybenzenesulphonyl chloride ≥95% | 67475-55-2 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC5547 | 3-Fluoro-4-methoxybenzenesulphonyl chloride ≥95% | 67475-55-2 | 5g | $58 | 2026-06-04 | Buy |
| Apolloscientific | PC5547 | 3-Fluoro-4-methoxybenzenesulphonyl chloride ≥95% | 67475-55-2 | 25g | $204 | 2026-06-04 | Buy |
| Matrix Scientific | 020070 | 3-Fluoro-4-methoxybenzenesulfonyl chloride | 67475-55-2 | 5.00g | $51 | 2026-05-18 | Buy |
Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI) Chemical Properties, Uses, Production
Synthesis
321-28-8
67475-55-2
The general procedure for the synthesis of 3-fluoro-4-methoxybenzenesulfonyl chloride from 2-fluoroanisole was as follows: 2-fluoroanisole (33.7 mL, 301 mmol) was dissolved in chloroform (250 mL), stirred and cooled to 0 °C. Subsequently, chlorosulfonic acid (50.0 mL, 752 mmol) was slowly added dropwise. After the dropwise addition, the reaction mixture was stirred at room temperature for 14 hours. After completion of the reaction, the mixture was poured into ice water (700 mL) and the aqueous phase was extracted with chloroform (2 x 200 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated to afford 3-fluoro-4-methoxybenzenesulfonyl chloride as a white fine solid (58.6 g, 87% yield) with a melting point of 80°C. 1H NMR (400 MHz, DMSO-d6) δ: 7.32 (m, 1H), 7.25 (dd, J = 11.5, 2.0 Hz, 1H), 7.05 (t, J = 8.5 Hz, 2.0 Hz, 1H). J = 8.5 Hz, 1H), 3.78 (s, 3H).
References
[1] Patent: WO2004/50631, 2004, A1. Location in patent: Page 122-123
Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI) Preparation Products And Raw materials
Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI) Suppliers
Global Suppliers ( 57)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Na Qian Chemical Technology Co. Ltd. | 13598610367 13598610367 | 2841375912@qq.com | China | 3575 | 52 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
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3-fluoro-4-methoxybenzenesulfonyl chloride(SALTDATA: FREE)
4-(Chlorosulphonyl)-2-fluoroanisole
3-Fluoro-4-methoxybenzenesulfonyl chloride 97%
Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI)
Benzenesulfonyl chloride, 3-fluoro-4-methoxy-
7475-55-2
67475-55-2
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