Butanedioic acid, compd. with (3S)-1-azabicyclo[2.2.2]oct-3-yl N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]carbamate (1:1)
![Butanedioic acid, compd. with (3S)-1-azabicyclo[2.2.2]oct-3-yl N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]carbamate (1:1) Structure](CAS/20211123/GIF/1629063-80-4.gif)
- CAS No.
- 1629063-80-4
- Chemical Name:
- Butanedioic acid, compd. with (3S)-1-azabicyclo[2.2.2]oct-3-yl N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]carbamate (1:1)
- Synonyms
- GZ402671succinate;SAR402671succinate;Venglustat succinate;Butanedioic acid, compd. with (3S)-1-azabicyclo[2.2.2]oct-3-yl N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]carbamate (1:1)
- CBNumber:
- CB910778327
- Molecular Formula:
- C24H30FN3O6S
- Molecular Weight:
- 507.58
- MDL Number:
- MOL File:
- 1629063-80-4.mol
- MSDS File:
- SDS
Butanedioic acid, compd. with (3S)-1-azabicyclo[2.2.2]oct-3-yl N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]carbamate (1:1) Properties
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO : ≥ 250 mg/mL (492.54 mM) |
| form | Solid |
| color | White to off-white |
| FDA UNII | XW65IGE2BT |
Butanedioic acid, compd. with (3S)-1-azabicyclo[2.2.2]oct-3-yl N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]carbamate (1:1) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0368981 | Ibiglustat succinate 99.71% | 1629063-80-4 | 2mg | $108 | 2026-06-04 | Buy |
| ChemScene | CS-0368981 | Ibiglustat succinate 99.71% | 1629063-80-4 | 5mg | $217 | 2026-06-04 | Buy |
| ChemScene | CS-0368981 | Ibiglustat succinate 99.71% | 1629063-80-4 | 10mg | $390 | 2026-06-04 | Buy |
| ChemScene | CS-0368981 | Ibiglustat succinate 99.71% | 1629063-80-4 | 25mg | $693 | 2026-06-04 | Buy |
| ChemScene | CS-0368981 | Ibiglustat succinate 99.71% | 1629063-80-4 | 50mg | $1040 | 2026-06-04 | Buy |
Butanedioic acid, compd. with (3S)-1-azabicyclo[2.2.2]oct-3-yl N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]carbamate (1:1) Chemical Properties, Uses, Production
Uses
Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat succinate can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease[1][2].
References
[1] Viel C, et al. Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model. Sci Rep. 2021;11(1):20945. Published 2021 Oct 22. DOI:10.1038/s41598-021-00404-5
[2] Peterschmitt MJ, et al. Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Oral Venglustat in Healthy Volunteers. Clin Pharmacol Drug Dev. 2021;10(1):86-98. DOI:10.1002/cpdd.865
[3] Iva Stojkovska, et al. Molecular mechanisms of α-synuclein and GBA1 in Parkinson’s disease. Cell Tissue Res. 2017. DOI:10.1007/s00441-017-2704-y
[4] Itier JM, et al. Effective clearance of GL-3 in a human iPSC-derived cardiomyocyte model of Fabry disease. J Inherit Metab Dis. 2014;37(6):1013-1022. DOI:10.1007/s10545-014-9724-5
Butanedioic acid, compd. with (3S)-1-azabicyclo[2.2.2]oct-3-yl N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]carbamate (1:1) Preparation Products And Raw materials
Raw materials
Preparation Products
Butanedioic acid, compd. with (3S)-1-azabicyclo[2.2.2]oct-3-yl N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]carbamate (1:1) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 4000862158 18117107507 | vip@med-life.cn | China | 4999 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50089 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
1629063-80-4 (Butanedioic acid, compd. with (3S)-1-azabicyclo[2.2.2]oct-3-yl N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]carbamate (1:1)) Related Search:
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