3-(3,4-Dimethylphenyl)propionic acid
- CAS No.
- 25173-76-6
- Chemical Name:
- 3-(3,4-Dimethylphenyl)propionic acid
- Synonyms
- 3-(3,4-diMethylphenyl)propanoic acid;3-(3,4-Dimethylphenyl);3,4-DiMethylbenzenepropanoic acid;Benzenepropanoic acid, 3,4-diMethyl-;3-(3,4-Dimethylphenyl)propionic acid;3-(3,4-Dimethylphenyl)propionicacid,96%;3-(3,4-DIMETHYLPHENYL)PROPIONIC ACID ISO 9001：2015 REACH
- CBNumber:
- CB9115424
- Molecular Formula:
- C11H14O2
- Molecular Weight:
- 178.23
- MDL Number:
- MFCD03425686
- MOL File:
- 25173-76-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2916399090 | |||||||||
| NFPA 704 |
|
3-(3,4-Dimethylphenyl)propionic acid price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR936979 | 3-(3,4-Dimethylphenyl)propionic acid >96% | 25173-76-6 | 1g | $25 | 2026-06-04 | Buy |
| Apolloscientific | OR936979 | 3-(3,4-Dimethylphenyl)propionic acid >96% | 25173-76-6 | 5g | $67 | 2026-06-04 | Buy |
| Apolloscientific | OR936979 | 3-(3,4-Dimethylphenyl)propionic acid >96% | 25173-76-6 | 25g | $240 | 2026-06-04 | Buy |
| Apolloscientific | OR936979 | 3-(3,4-Dimethylphenyl)propionic acid >96% | 25173-76-6 | 100g | $910 | 2026-06-04 | Buy |
| Activate Scientific | AS85115 | 3,4-Dimethylbenzenepropanoic acid 98% | 25173-76-6 | 1g | $55 | 2026-06-04 | Buy |
3-(3,4-Dimethylphenyl)propionic acid Chemical Properties, Uses, Production
Uses
3-(3,4-Dimethylphenyl)propanoic Acid is a useful reagent for preparation of pyrazolotetrahydropyridines as orexin receptor antagonists.
Synthesis
102-46-5
105-53-3
25173-76-6
Step 1) Synthesis of 3-(3,4-dimethylphenyl)propionic acid: 10.0 g of sodium metal was added batchwise to 70.0 mL of diethyl malonate dissolved in 400 mL of anhydrous ethanol. The reaction mixture was stirred at 0 °C for 30 min; 66.5 g of 3,4-dimethylbenzyl chloride was then added slowly and dropwise. The reaction mixture was continued to be stirred at room temperature for 1 hour, followed by reflux heating for 4 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure. The residue was dissolved in ether and the organic phase was washed with water. After concentrating the organic phase under reduced pressure, it was mixed with 500 mL of water and 170 g KOH; the mixture was heated at reflux for 24 hours. The reaction solution was concentrated under reduced pressure to half the original volume and 200 mL of 98% sulfuric acid was slowly added. The resulting solution was heated at reflux for 24 h. After cooling, the solution was extracted twice with 300 mL of ethyl acetate. The organic phases were combined, the solvent was removed by distillation under reduced pressure and the residue was recrystallized from boiling hexane to give 42.1 g of the title compound as a white solid (yield: 55%). Melting point: 82 °C. 1H-NMR (300 MHz, CDCl3) δ 2.22 (s, 3H, CH3), 2.24 (s, 3H, CH3), 2.66 (t, J = 8 Hz, 2H, ArCH2), 2.89 (t, J = 8 Hz, 2H, CH2CO), 6.93-7.70 (m, 3H, ArH).
References
[1] Patent: US5670546, 1997, A
[2] Patent: EP721939, 1996, A1
3-(3,4-Dimethylphenyl)propionic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3997 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Wuhan Kaymke Chemical Co., Ltd., | 027-87342388 18086026008 | sales@kaymke.com | China | 3537 | 55 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
View Latest Price from 3-(3,4-Dimethylphenyl)propionic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 3-(3,4-DIMETHYLPHENYL)PROPIONIC ACID
25173-76-6
|
$1.10 | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited |
-
- 3-(3,4-DIMETHYLPHENYL)PROPIONIC ACID
25173-76-6
- $1.10
- 99.0% Min
- Dideu Industries Group Limited
