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Ganciclovir Mono-O-acetate

Ganciclovir Mono-O-acetate structure

CAS No.: 88110-89-8

Chemical Name:: Ganciclovir Mono-O-acetate

Synonyms: Monacetyl ganciclor;Gancyclovir Impurity 20;Mono acetyl Ganciclovir;Valganciclovir USP RC E;Ganciclovir Impurity 30;O-Monoacetylganciclovir;Ganciclovir Impurity 16;Mono-O-AcetylGanciclovir;Mono-O-acetateGanciclovir;Ganciclovir Mono-O-acetate

CBNumber:: CB91176343

Molecular Formula:: C11H15N5O5

Molecular Weight:: 297.27

MDL Number:: MFCD09840659

MOL File:: 88110-89-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:48:56

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Ganciclovir Mono-O-acetate Properties

Melting point	194-197°C
Density	1.66±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	9.32±0.20(Predicted)
color	White
FDA UNII	VOP6XHY7OL

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H360-H351-H340
Precautionary statements	P201-P202-P281-P308+P313-P405-P501
REACH Registrations	Active

Ganciclovir Mono-O-acetate price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-G235010-25MG	Ganciclovir Mono-O-acetate	88110-89-8	25mg	$256	2026-06-03	Buy
TRC	TRC-G235010-250MG	Ganciclovir Mono-O-acetate	88110-89-8	250mg	$2098	2026-06-03	Buy
TRC	TRC-G235010-100MG	Ganciclovir Mono-O-acetate	88110-89-8	100mg	$931	2026-06-03	Buy
Biosynth	FG23646	Ganciclovir mono-O-acetate	88110-89-8	5g	$900	2026-06-04	Buy
Biosynth	FG23646	Ganciclovir mono-O-acetate	88110-89-8	50g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-G235010-25MG	25mg	$256	Buy
TRC-G235010-250MG	250mg	$2098	Buy
TRC-G235010-100MG	100mg	$931	Buy
FG23646	5g	$900	Buy
FG23646	50g	$900	Buy

Ganciclovir Mono-O-acetate Chemical Properties, Uses, Production

Chemical Properties

White Solid

Uses

Ganciclovir derivative.

Synthesis

2466-76-4

82410-32-0

88110-89-8

The general procedure for the synthesis of 2-((2-amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl acetate from 1-acetylimidazole and 2-amino-9-(((1,3-dihydroxypropan-2- yl)oxy)methyl)-1H-purin-6(9H)-one is as follows: 500.0 g (1.96 mol, 1.0 equiv) of ganciclovir, 244.4 g (2.35 mol, 1.2 eq.) of trimethyl borate and 7.5 kg of toluene were added to the reaction vessel and heated to reflux for 5 hours. The progress of the reaction was monitored by TLC to confirm the complete reaction of the ingredients. The reaction mixture was cooled to room temperature and 396.7 g (3.93 mol, 2.0 eq.) of triethylamine was added, followed by 323.7 g (2.94 mol, 1.5 eq.) of 1-acetylimidazole, and stirred for 6 hours at room temperature. The ratio of monoacetyl ganciclovir to N,O-diacetyl ganciclovir was analyzed by HPLC to be 94:4. The reaction mixture was cooled to 0-10 °C and 2.0 kg of methanol was slowly added dropwise followed by stirring for 2 h at room temperature. The solvent was removed by concentration under reduced pressure, 3.0 kg of ethyl acetate was added, the organic layer was washed with 500 g of water and the aqueous layer was extracted with 500 g of ethyl acetate. The organic layers were combined, concentrated under reduced pressure and recrystallized by ethanol to give 440.9 g of colorless crystal product in 75.7% yield and 99.2% purity.

References

[1] Patent: CN108383840, 2018, A. Location in patent: Paragraph 0033; 0034; 0043; 0045; 0050
[2] Patent: CN108503642, 2018, A. Location in patent: Paragraph 0028-0034; 0039; 0040; 0042-0050; 0053; 0054
[3] Patent: CN108503641, 2018, A. Location in patent: Paragraph 0030; 0031; 0033; 0034; 0040-0051; 0054; 0055
[4] Patent: CN108409739, 2018, A. Location in patent: Paragraph 0033; 0034; 0043; 0045; 0050

Ganciclovir Mono-O-acetate synthesis

Synthesis of Ganciclovir Mono-O-acetate from Vinyl acetate and Ganciclovir

Ganciclovir Mono-O-acetate Preparation Products And Raw materials

Raw materials

1-Acetylimidazole 6H-Purin-6-one, 1,9-dihydro-9-[[1-(hydroxyMethyl)-2-(triphenylMethoxy)ethoxy]Methyl]-2-[(triphenylMethyl)aMino]- N-[9-[[2-(Acetyloxy)-1-[(acetyloxy)methyl]ethoxy]methyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]acetamide Ganciclovir Trimethyl borate

Toluene Vinyl acetate Trimethyl orthoacetate

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Preparation Products

Ganciclovir Mono-O-acetate Suppliers

Global Suppliers ( 157)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
Bsisun HK Imoprt And Export Company Limited	+86-18068513926		China	1273	55
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4773	55
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2774	58
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Jia Xing Isenchem Co.,Ltd	66
Adamas Reagent, Ltd.	59
Chemsky（shanghai）International Co.,Ltd.	50
BOC Sciences	65
Haoyuan Chemexpress Co., Ltd.	61
Bsisun HK Imoprt And Export Company Limited	55
Guangzhou Isun Pharmaceutical Co., Ltd	55
AdooQ BioScience, LLC	58
Bide Pharmatech Ltd.	60

View Latest Price from Ganciclovir Mono-O-acetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	Ganciclovir Mono-O-acetate 88110-89-8	$1.10	1g	99.0% Min	100 Tons	Dideu Industries Group Limited
2026-08-08	Ganciclovir Mono-O-acetate 88110-89-8		1kg	99.0%min	10tons	Hangzhou ICH Biofarm Co., Ltd
2026-06-30	Ganciclovir Mono-O-acetate 88110-89-8		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

Ganciclovir Mono-O-acetate
88110-89-8
$1.10
99.0% Min
Dideu Industries Group Limited

Ganciclovir Mono-O-acetate
88110-89-8
99.0%min
Hangzhou ICH Biofarm Co., Ltd

Ganciclovir Mono-O-acetate
88110-89-8
98.0%
Shaanxi Dideu New Materials Co. Ltd

Ganciclovir Mono-O-acetate Spectrum

Ganciclovir Mono-O-acetate(88110-89-8)¹HNMR

88110-89-8 (Ganciclovir Mono-O-acetate) Related Search:

N-Methyl Valganciclovir Hydrochloride Acyclovir N-Methyl-L-valinate Hydrochloride Bis Valacyclovir (~90%) Cbz-Valaciclovir (S)-Valganciclovir DiMethyl Ether IMpurity DISCONTINUED

Guanine L-Valine 2-Hydroxyethyl Ester 4-Methylbenzenesulfonate N-ForMyl Valacyclovir Bis(L-Valine) Ester Ganciclovir TFA Salt Acyclovir N-Methylene Dimer

DVCUGHHGLKCBMT-QVDQXJPCSA-N Valganciclovir Dimer Stereoisomer A, B, C 9-[[2-(α-L-Alanyloxy)ethoxy]methyl]guanine Hydrochloride INDEX NAME NOT YET ASSIGNED Valaciclovir iMpurity D

D-Valganciclovir Hydrochloride 9-(1,3-diacetate-2-propoxymethyl)guanine ZCDDBUOENGJMLV-DDWIOCJRSA-N

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9-[[2-(Acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro- 6H-Purin-6-on Ganciclovir Mono-O-acetate Gancyclovir Impurity 20 6h-purin-6-one,9-[[2-(acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro- [2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] acetate 9-[[2-(Acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro- 6H-Purin-6-one Ganciclovir-Mono-O-acetate(Mono-O-AcetylGanciclovir) 2-[(2-aMino-6-oxo-3,6-dihydro-9H-purin-9-yl)Methoxy]-3-hydroxypropyl acetate 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-acetoxy-1-propanol Mono-O-acetateGanciclovir Mono acetyl Ganciclovir Mono-O-AcetylGanciclovir Mono-O-acetateGanciclovir(Impuritycontrol) Valganciclovir USP RC E 2-((2-amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl acetate Ganciclovir Mono-O-acetate ISO 9001：2015 REACH valganciclovirhydrochloride iMpurit E Monacetyl ganciclor Ganciclovir Impurity 30 Valganciclovir Related Compound E (Monoacetoxy Ganciclovir) 2-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]-3-hydro... 3-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-6,7-dihydroxy-3,5,6,7- tetrahydro-9H-imidazo[1,2-a]purin-9-one O-Monoacetylganciclovir Ganciclovir Impurity 16 2(R,S)-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-3-acetoxy-1-propanol Valganciclovir EP Impurity E Valganciclovir Hydrochloride Impurity: 9-[[2-(Acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro-6H-Purin-6-one (Monoacetoxy ganciclovir) 88110-89-8 Intermediates & Fine Chemicals Pharmaceuticals