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Ganciclovir Mono-O-acetate

Ganciclovir Mono-O-acetate structure

CAS No.: 88110-89-8

Chemical Name:: Ganciclovir Mono-O-acetate

Synonyms: Monacetyl ganciclor;Gancyclovir Impurity 20;Mono acetyl Ganciclovir;Valganciclovir USP RC E;Ganciclovir Impurity 30;O-Monoacetylganciclovir;Ganciclovir Impurity 16;Mono-O-AcetylGanciclovir;Mono-O-acetateGanciclovir;Ganciclovir Mono-O-acetate

CBNumber:: CB91176343

Molecular Formula:: C11H15N5O5

Molecular Weight:: 297.27

MDL Number:: MFCD09840659

MOL File:: 88110-89-8.mol

MSDS File:: SDS

Last updated:2025-08-08 17:45:00

Product description	Number	Pack Size	Price
GanciclovirMono-O-acetate	G235010	25mg	$185
2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-acetoxy-1-propanol 97.29%	CS-M3368	100g	$214
GanciclovirMono-O-acetate	1320EM	1g	$69
2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-acetoxy-1-propanol 97.29%	CS-M3368	25g	$71
GANCICLOVIR MONO-O-ACETATE 95.00%	API0000578	50MG	$721.88
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Ganciclovir Mono-O-acetate Properties

Melting point	194-197°C
Density	1.66±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	9.32±0.20(Predicted)
color	White
FDA UNII	VOP6XHY7OL

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H360-H351-H340
Precautionary statements	P201-P202-P281-P308+P313-P405-P501

Ganciclovir Mono-O-acetate price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	G235010	GanciclovirMono-O-acetate	88110-89-8	25mg	$185	2021-12-16	Buy
ChemScene	CS-M3368	2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-acetoxy-1-propanol 97.29%	88110-89-8	100g	$214	2021-12-16	Buy
AK Scientific	1320EM	GanciclovirMono-O-acetate	88110-89-8	1g	$69	2021-12-16	Buy
ChemScene	CS-M3368	2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-acetoxy-1-propanol 97.29%	88110-89-8	25g	$71	2021-12-16	Buy
American Custom Chemicals Corporation	API0000578	GANCICLOVIR MONO-O-ACETATE 95.00%	88110-89-8	50MG	$721.88	2021-12-16	Buy

Product number	Packaging	Price	Buy
G235010	25mg	$185	Buy
CS-M3368	100g	$214	Buy
1320EM	1g	$69	Buy
CS-M3368	25g	$71	Buy
API0000578	50MG	$721.88	Buy

Ganciclovir Mono-O-acetate Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Ganciclovir derivative.

Synthesis

2466-76-4

82410-32-0

88110-89-8

The general procedure for the synthesis of 2-((2-amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl acetate from 1-acetylimidazole and 2-amino-9-(((1,3-dihydroxypropan-2- yl)oxy)methyl)-1H-purin-6(9H)-one is as follows: 500.0 g (1.96 mol, 1.0 equiv) of ganciclovir, 244.4 g (2.35 mol, 1.2 eq.) of trimethyl borate and 7.5 kg of toluene were added to the reaction vessel and heated to reflux for 5 hours. The progress of the reaction was monitored by TLC to confirm the complete reaction of the ingredients. The reaction mixture was cooled to room temperature and 396.7 g (3.93 mol, 2.0 eq.) of triethylamine was added, followed by 323.7 g (2.94 mol, 1.5 eq.) of 1-acetylimidazole, and stirred for 6 hours at room temperature. The ratio of monoacetyl ganciclovir to N,O-diacetyl ganciclovir was analyzed by HPLC to be 94:4. The reaction mixture was cooled to 0-10 °C and 2.0 kg of methanol was slowly added dropwise followed by stirring for 2 h at room temperature. The solvent was removed by concentration under reduced pressure, 3.0 kg of ethyl acetate was added, the organic layer was washed with 500 g of water and the aqueous layer was extracted with 500 g of ethyl acetate. The organic layers were combined, concentrated under reduced pressure and recrystallized by ethanol to give 440.9 g of colorless crystal product in 75.7% yield and 99.2% purity.

References

[1] Patent: CN108383840, 2018, A. Location in patent: Paragraph 0033; 0034; 0043; 0045; 0050
[2] Patent: CN108503642, 2018, A. Location in patent: Paragraph 0028-0034; 0039; 0040; 0042-0050; 0053; 0054
[3] Patent: CN108503641, 2018, A. Location in patent: Paragraph 0030; 0031; 0033; 0034; 0040-0051; 0054; 0055
[4] Patent: CN108409739, 2018, A. Location in patent: Paragraph 0033; 0034; 0043; 0045; 0050

Ganciclovir Mono-O-acetate synthesis

Synthesis of Ganciclovir Mono-O-acetate from Vinyl acetate and Ganciclovir

Ganciclovir Mono-O-acetate Preparation Products And Raw materials

Raw materials

1-Acetylimidazole 6H-Purin-6-one, 1,9-dihydro-9-[[1-(hydroxyMethyl)-2-(triphenylMethoxy)ethoxy]Methyl]-2-[(triphenylMethyl)aMino]- N-[9-[[2-(Acetyloxy)-1-[(acetyloxy)methyl]ethoxy]methyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]acetamide Ganciclovir Trimethyl borate

Toluene Vinyl acetate Trimethyl orthoacetate

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Preparation Products

Ganciclovir Mono-O-acetate Suppliers

Global( 155)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1014	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58

Supplier	Advantage
Hangzhou ICH Biofarm Co., Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
Shanghai Yingrui Biopharma Co.,Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58

View Lastest Price from Ganciclovir Mono-O-acetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-07-25	Ganciclovir Mono-O-acetate 88110-89-8	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-07-08	Ganciclovir Mono-O-acetate 88110-89-8	US $0.00-0.00 / kg	1kg	99.0%min	10tons	Hangzhou ICH Biofarm Co., Ltd
2024-10-28	Ganciclovir mono-O-acetate 88110-89-8	US $0.00 / mg			10g	TargetMol Chemicals Inc.

Ganciclovir Mono-O-acetate
88110-89-8
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

Ganciclovir Mono-O-acetate
88110-89-8
US $0.00-0.00 / kg
99.0%min
Hangzhou ICH Biofarm Co., Ltd

Ganciclovir mono-O-acetate
88110-89-8
US $0.00 / mg
TargetMol Chemicals Inc.

Ganciclovir Mono-O-acetate Spectrum

Ganciclovir Mono-O-acetate(88110-89-8)¹HNMR

88110-89-8(Ganciclovir Mono-O-acetate)Related Search:

Acyclovir N-Methyl-L-valinate Hydrochloride N-Methyl Valganciclovir Hydrochloride N-ForMyl Valacyclovir L-Valine 2-Hydroxyethyl Ester 4-Methylbenzenesulfonate Guanine

(S)-Valganciclovir DiMethyl Ether IMpurity DISCONTINUED Cbz-Valaciclovir Bis Valacyclovir (~90%) Bis(L-Valine) Ester Ganciclovir TFA Salt Acyclovir N-Methylene Dimer

DVCUGHHGLKCBMT-QVDQXJPCSA-N Valganciclovir Dimer Stereoisomer A, B, C 9-[[2-(α-L-Alanyloxy)ethoxy]methyl]guanine Hydrochloride INDEX NAME NOT YET ASSIGNED Valaciclovir iMpurity D

D-Valganciclovir Hydrochloride 9-(1,3-diacetate-2-propoxymethyl)guanine ZCDDBUOENGJMLV-DDWIOCJRSA-N

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9-[[2-(Acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro- 6H-Purin-6-on Ganciclovir Mono-O-acetate Gancyclovir Impurity 20 6h-purin-6-one,9-[[2-(acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro- [2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] acetate 9-[[2-(Acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro- 6H-Purin-6-one Ganciclovir-Mono-O-acetate(Mono-O-AcetylGanciclovir) 2-[(2-aMino-6-oxo-3,6-dihydro-9H-purin-9-yl)Methoxy]-3-hydroxypropyl acetate 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-acetoxy-1-propanol Mono-O-acetateGanciclovir Mono acetyl Ganciclovir Mono-O-AcetylGanciclovir Mono-O-acetateGanciclovir(Impuritycontrol) Valganciclovir USP RC E 2-((2-amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl acetate Ganciclovir Mono-O-acetate ISO 9001：2015 REACH valganciclovirhydrochloride iMpurit E Monacetyl ganciclor Ganciclovir Impurity 30 Valganciclovir Related Compound E (Monoacetoxy Ganciclovir) 2-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]-3-hydro... 3-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-6,7-dihydroxy-3,5,6,7- tetrahydro-9H-imidazo[1,2-a]purin-9-one O-Monoacetylganciclovir Ganciclovir Impurity 16 2(R,S)-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-3-acetoxy-1-propanol Valganciclovir EP Impurity E Valganciclovir Hydrochloride Impurity: 9-[[2-(Acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro-6H-Purin-6-one (Monoacetoxy ganciclovir) 88110-89-8 Intermediates & Fine Chemicals Pharmaceuticals