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Trimethyl orthoacetate

Trimethyl orthoacetate Structure
Trimethyl orthoacetate structure
CAS No.
1445-45-0
Chemical Name:
Trimethyl orthoacetate
Synonyms
TMOA;1,1,1-TRIMETHOXYETHANE;CH3C(OCH3)3;orthoacetate;Ethane, 1,1,1-trimethoxy-;Methyl orthoacetate;Trimethylorthoaceate;Trimethylorthoacetat;trimethyl-acetate;Trimethyl o-acetate
CBNumber:
CB5759743
Molecular Formula:
C5H12O3
Molecular Weight:
120.15
MDL Number:
MFCD00008477
MOL File:
1445-45-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:33:18
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Trimethyl orthoacetate Properties

Boiling point 107-109 °C(lit.)
Density 0.944 g/mL at 25 °C(lit.)
vapor pressure 20 hPa (20 °C)
refractive index n20/D 1.388(lit.)
Flash point 62 °F
storage temp. Store below +30°C.
solubility Chloroform (Sparingly), Methanol (Slightly)
form Liquid
color Clear colorless to slightly brown
Specific Gravity 0.960 (20/4℃)
Water Solubility HYDROLYSIS
Sensitive Moisture Sensitive
BRN 1098338
Henry's Law Constant 6.4×10-1 mol/(m3Pa) at 25℃, Guthrie (1973)
InChI 1S/C5H12O3/c1-5(6-2,7-3)8-4/h1-4H3
InChIKey HDPNBNXLBDFELL-UHFFFAOYSA-N
SMILES COC(C)(OC)OC
LogP 1.13 at 25℃
CAS DataBase Reference 1445-45-0(CAS DataBase Reference)
FDA UNII 04H7A3FK37
NIST Chemistry Reference Ethane, 1,1,1-trimethoxy-(1445-45-0)
EPA Substance Registry System Trimethyl orthoacetate (1445-45-0)
UNSPSC Code 12352112
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Danger
Hazard statements  H315-H319-H225
Precautionary statements  P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  F,Xi
Risk Statements  11-43-38-36/37/38
Safety Statements  16-37/39-24-33-26-7/9
RIDADR  UN 3272 3/PG 2
WGK Germany  1
TSCA  TSCA listed
HazardClass  3
PackingGroup  II
HS Code  29159080
Storage Class 3 - Flammable liquids
Hazard Classifications Eye Irrit. 2
Flam. Liq. 2
Skin Sens. 1B
Toxicity LD50 orally in Rabbit: > 2000 mg/kg
REACH Registrations Active
NFPA 704
3
2 1

Trimethyl orthoacetate price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.18804 Trimethyl orthoacetate for synthesis 1445-45-0 100mL $71 2026-04-30 Buy
Sigma-Aldrich 8.18804 Trimethyl orthoacetate for synthesis 1445-45-0 500mL $157 2026-04-30 Buy
Sigma-Aldrich 237876 Trimethyl orthoacetate 99% 1445-45-0 100ml $64.4 2026-04-30 Buy
Sigma-Aldrich 237876 Trimethyl orthoacetate 99% 1445-45-0 500ml $201 2026-04-30 Buy
TCI Chemical O0115 Trimethyl Orthoacetate >98.0%(GC) 1445-45-0 25mL $30 2026-04-30 Buy
Product number Packaging Price Buy
8.18804 100mL $71 Buy
8.18804 500mL $157 Buy
237876 100ml $64.4 Buy
237876 500ml $201 Buy
O0115 25mL $30 Buy

Trimethyl orthoacetate Chemical Properties,Uses,Production

Chemical Properties

CLEAR COLOURLESS TO SLIGHTLY BROWN LIQUID

Uses

Trimethyl orthoacetate has been used in the preparation of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-amino-9-(3-alkoxycarbonyl-oxymethyl-4-alkoxycarbonyloxybut -1-yl)purines.

General Description

Kinetics and mechanism of gas-phase elimination of trimethyl orthoacetate has been examined over the temperature range of 310-369°C and pressure range of 50-130Torr.

Toxics Screening Level

The ITSL of Trimethyl orthoacetate is 24 μg/m3 with annual averaging.

Trimethyl orthoacetate synthesis

67-56-1
75-05-8
1445-45-0
Synthesis of Trimethyl orthoacetate from Methanol and Acetonitrile

Trimethyl orthoacetate Preparation Products And Raw materials

Raw materials

anhydrous Acetonitrile Sodium Methoxide Ethane, (dimethoxymethoxy)- 1-ethoxy-1,1-dimethoxyethane METHYL ACETIMIDATE HYDROCHLORIDE
1,1-Dichloro-1-nitroethane 1,1-DIMETHOXYETHENE Ethane, 1,1'-[(methoxymethylene)bis(oxy)]bis- trans-Methyl crotonate

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Preparation Products

Methyl 3,3-dimethylpent-4-enoate Methyl N-cyanoethanimideate Triethyl orthoacetate 4,6-Dimethylpyrimidine-5-carboxylic acid N-TERT-BUTYLACETAMIDE
Methyl 2-chloro-3-nitrobenzoate Methyl 2,6-dimethoxybenzoate EthaniMidaMide, N,N'-bis(1-Methylethyl)- DODECYL ACETATE N-Isopropylacetamide
Ganciclovir Mono-O-acetate

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Trimethyl orthoacetate Suppliers

Global( 418)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Xinhua Pharmceutical Co.,LTD 0533- 2196801 yaojianyong@xhzy.com China 70 60
Wuhan Ji Ye Sheng Chemical Co., Ltd. 027-13545242311 13545242311 2471076463@qq.com China 1000 58
Shandong Chongcheng Energy Technology Co., Ltd 18253333366 81505319@qq.com China 2153 58
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
Jinan Renyuan Chemical Co. Ltd 0531-86128689 13188898795 819291565@qq.com China 255 58
Zibo Bowei Biotechnology Co., Ltd. 130-53332153 13053332153 13573387648@163.com China 76 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Supplier Advantage
Shandong Xinhua Pharmceutical Co.,LTD 60
Wuhan Ji Ye Sheng Chemical Co., Ltd. 58
Shandong Chongcheng Energy Technology Co., Ltd 58
Sichuan Kulinan Technology Co., Ltd 57
Jinan Renyuan Chemical Co. Ltd 58
Zibo Bowei Biotechnology Co., Ltd. 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57

Related articles

View Lastest Price from Trimethyl orthoacetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Trimethyl Orthoacetate pictures 2026-05-28 Trimethyl Orthoacetate
1445-45-0
 $5.70 10KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
Trimethyl orthoacetate pictures 2026-03-20 Trimethyl orthoacetate
1445-45-0
 $10.00 1kg 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd
Trimethyl Orthoacetate pictures 2025-08-20 Trimethyl Orthoacetate
1445-45-0
 1kg 99.99% 20 tons Chongqing Soarwin Technology Co., Ltd

Trimethyl orthoacetate Spectrum

Trimethyl orthoacetate(1445-45-0)MSTrimethyl orthoacetate(1445-45-0)1HNMRTrimethyl orthoacetate(1445-45-0)13CNMRTrimethyl orthoacetate(1445-45-0)IR1Trimethyl orthoacetate(1445-45-0)Raman

1445-45-0(Trimethyl orthoacetate)Related Search:

Methyl acetate Methyl trifluoroacetate Methyl chloroacetate Trimethyl phosphonoacetate Trimethyl phosphate
Methyl cyanoacetate Methyl 2,2-dimethylphenylacetate Benzyl acetate Methyl bromoacetate Trimethyl borate
Triethyl orthopropionate Triethyl orthobenzoate Trimethyl orthobutyrate Trimethyl orthopropionate 1,1,1-Trimethoxypentane
Triethyl orthoacetate ortho-n-Valeric acid triethyl ester Trimethyl orthobenzoate

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1,1,1-trimethoxy-ethan Methyl orthoacetate trimethyl-acetate Trimethylorthoaceate ORTHOACETIC ACID TRIMETHYL ESTER TRIMETHYL ORTHOACETATE 1,1,1-Trimethoxyethane Orthoacetic Acid Trimethyl Ester Methylorthoformic acid trimethyl ester Trimethyl orthoacetate,98% Orthoacetic Acid Trimethyl Ester 1,1,1-Trimethoxyethane The originalacetic acidtriMethyl ester The original three Methyl acetate Trimethyl o-acetate TrimethoxyOrthoAcetate Trimethylorthoacetat Trimethyl orthoacetate,1,1,1-Trimethoxyethane TriMethyl orthoacetate, 98% 100ML TriMethyl orthoacetate, 98% 500ML Trimethyl Ortho Acetate (TMOA) TrimethylOrthoacetate> TRIMETHYL ORTHOACETATE FOR SYNTHESIS TRMETHYL ORTHOACETATE 1,1,1-TRIMETHOXYETHANE CH3C(OCH3)3 Ethane, 1,1,1-trimethoxy- orthoacetate TMOA 1445-45-0 145-45-0 Acetals/Ketals/Ortho Esters Organic Building Blocks Building Blocks Orthoesters Oxygen Compounds Organic synthesis Acetals/Ketals/Ortho Esters Building Blocks Chemical Synthesis Organic Building Blocks Oxygen Compounds Orthoesters