Midaglizole
- CAS No.
- 66529-17-7
- Chemical Name:
- Midaglizole
- Synonyms
- DG-5128;Midaglizole;DG5128 free base;2-[2-(2-Imidazolin-2-yl)-1-phenylethyl]pyridine;4,5-Dihydro-2-[2-(2-pyridinyl)-2-phenylethyl]-1H-imidazole;Pyridine, 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]-;(±)-DG5128 free base|||DG5128 free base|||(±)-DG5128 free base
- CBNumber:
- CB91179197
- Molecular Formula:
- C16H17N3
- Molecular Weight:
- 251.33
- MDL Number:
- MFCD00864171
- MOL File:
- 66529-17-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Midaglizole 98.28% | CS-0634380 | 5mg | $433 |
| Midaglizole 98.28% | CS-0634380 | 10mg | $737 |
| Midaglizole 98.28% | CS-0634380 | 25mg | $1462 |
| Midaglizole 98.28% | CS-0634380 | 50mg | $2383 |
| Midaglizole 98.28% | CS-0634380 | 100mg | $3683 |
| storage temp. | Store at -20°C |
|---|---|
| form | Solid |
| color | White to off-white |
| FDA UNII | 44NWV6A237 |
Midaglizole price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0634380 | Midaglizole 98.28% | 66529-17-7 | 5mg | $433 | 2026-06-04 | Buy |
| ChemScene | CS-0634380 | Midaglizole 98.28% | 66529-17-7 | 10mg | $737 | 2026-06-04 | Buy |
| ChemScene | CS-0634380 | Midaglizole 98.28% | 66529-17-7 | 25mg | $1462 | 2026-06-04 | Buy |
| ChemScene | CS-0634380 | Midaglizole 98.28% | 66529-17-7 | 50mg | $2383 | 2026-06-04 | Buy |
| ChemScene | CS-0634380 | Midaglizole 98.28% | 66529-17-7 | 100mg | $3683 | 2026-06-04 | Buy |
Midaglizole Chemical Properties,Uses,Production
Uses
Midaglizole ((±)-DG5128 free base, DG5128 free base) is a potent α2-adrenoceptor antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo[1][2][3].
in vivo
Midaglizole (3, 30 mg/kg; i.v.) increases blood pressure in rats[1].
Midaglizole (0.2, 1, 2 mg/kg; infusion) reduces blood glucose levels in dags[2].
| Animal Model: | 290-450 g, Male Wistar rats[1] |
| Dosage: | 3, 30 mg/kg |
| Administration: | I.v. |
| Result: | Increased the blood pressure by 27 and 64 mmHg at 3, 30 mg/kg, respectively. |
| Animal Model: | Dogs[2] |
| Dosage: | 0.2, 1, 2 mg/kg |
| Administration: | Superior pancreaticoduodeneal artery infusion |
| Result: | Reduced blood glucose levels by stimulating insulin release from the pancreatic islets. |
References
[1] Hirohashi M, et al. Intrinsic pressor activity of midaglizole, an alpha-2 adrenoceptor antagonist, in pithed rats. Jpn J Pharmacol. 1990 Aug;53(4):519-20. DOI:10.1254/jjp.53.519
[2] Ohneda K, et al. Mechanism of insulin secretion by midaglizole. Diabetes Res Clin Pract. 1993 Feb;19(2):127-32. DOI:10.1016/0168-8227(93)90105-e
[3] Proks P, et al. Inhibition of recombinant K(ATP) channels by the antidiabetic agents midaglizole, LY397364 and LY389382. Eur J Pharmacol. 2002 Sep 27;452(1):11-9. DOI:10.1016/s0014-2999(02)02234-3
Midaglizole Preparation Products And Raw materials
Raw materials
Preparation Products
Midaglizole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9782 | 55 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 55 |
| TargetMol Chemicals Inc. | 58 |
View Lastest Price from Midaglizole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Midaglizole
66529-17-7
|
$1400.00-2500.00 | 10g | TargetMol Chemicals Inc. |
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- Midaglizole
66529-17-7
- $1400.00-2500.00
- TargetMol Chemicals Inc.
