3-Pyridinemethanol,alpha,6-dimethyl-(6CI,9CI)
- CAS No.
- 100189-16-0
- Chemical Name:
- 3-Pyridinemethanol,alpha,6-dimethyl-(6CI,9CI)
- Synonyms
- 5-(1-Hydroxyethyl);1-(6-methyl-3-pyridyl)ethanol;a,6-diMethyl-3-PyridineMethanol;1-(6-Methyl-3-pyridinyl)ethanol;α,6-DiMethyl-3-pyridineMethanol;3-Pyridinemethanol, α,6-dimethyl-;3-Pyridinemethanol, a,6-dimethyl-;5-(1-Hydroxyethyl)-2-methylpyridine;3-(1-Hydroxyethyl)-6-Methylpyridine;6-5-(1-Hydroxyethyl)-2-methylpyridine
- CBNumber:
- CB91297794
- Molecular Formula:
- C8H11NO
- Molecular Weight:
- 137.18
- MDL Number:
- MFCD06637422
- MOL File:
- 100189-16-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| HS Code | 2933399990 |
3-Pyridinemethanol,alpha,6-dimethyl-(6CI,9CI) price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR946325 | 5-(1-Hydroxyethyl)-2-methylpyridine 95% | 100189-16-0 | 1g | $117 | 2026-06-04 | Buy |
| Activate Scientific | AS42692 | 5-(1-Hydroxyethyl)-2-methylpyridine 97% | 100189-16-0 | 1g | $95 | 2026-06-04 | Buy |
| Activate Scientific | AS42692 | 5-(1-Hydroxyethyl)-2-methylpyridine 97% | 100189-16-0 | 5g | $302 | 2026-06-04 | Buy |
| Matrix Scientific | 295024 | 5-(1-Hydroxyethyl)-2-methylpyridine | 100189-16-0 | 250.00mg | $38 | 2026-05-19 | Buy |
| Matrix Scientific | 295024 | 5-(1-Hydroxyethyl)-2-methylpyridine | 100189-16-0 | 1.00g | $62 | 2026-05-19 | Buy |
3-Pyridinemethanol,alpha,6-dimethyl-(6CI,9CI) Chemical Properties, Uses, Production
Uses
5-(1-Hydroxyethyl)-2-methylpyridine is an intermediate used in the synthesis of metabolites of the antidiabetic, antihyperglycemic agent Pioglitazone (P471000).
Synthesis
36357-38-7
56019-64-8
General procedure for the synthesis of 6-methyl-3-(1-hydroxyethyl)pyridine from 1-(6-methylpyridin-3-yl)ethanone: Sodium borohydride (2.3 g, 0.06 mol) was added in batches to a solution of 1-(6-methylpyridin-3-yl)ethanol (160 ml) of 1-(6-methylpyridin-3-yl)ethanone (16.4 g, 0.121 mol) at 30 °C, maintaining a constant temperature and continuously stirring the reaction mixture. After 1 hour of reaction, the reaction mixture was diluted with saturated sodium bicarbonate solution (2 x 200 ml) and subsequently extracted with dichloromethane (2 x 500 ml). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give a light yellow oil. The crude product was purified by fast column chromatography (eluent: 5% methanol/dichloromethane) to afford 6-methyl-3-(1-hydroxyethyl)pyridine (17.0 g, two-step yield 93%) as a pale yellow oil.ES-MS [M + 1]+ : 138.1. 1H NMR (400 MHz, CDCl3): δ 8.35 (d, J = 2.0 Hz, 1H), δ 7.63 (dd, J = 8.0,2.4 Hz, 1H), 7.12 (d, J = 8.0 Hz, 1H), 4.89 (q, J = 6.5 Hz, 1H), 3.30 (brs, 1H), 2.50 (s, 3H), 1.48 (d, J = 6.5 Hz, 3H).
References
[1] Journal of Medicinal Chemistry, 1996, vol. 39, # 26, p. 5053 - 5063
[2] Chemical and Pharmaceutical Bulletin, 1995, vol. 43, # 12, p. 2168 - 2172
[3] Chemische Berichte, 1947, vol. 80, p. 502,505
[4] Patent: WO2009/80637, 2009, A1. Location in patent: Page/Page column 32
[5] Patent: WO2015/150476, 2015, A1. Location in patent: Page/Page column 23; 24
3-Pyridinemethanol,alpha,6-dimethyl-(6CI,9CI) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| ChangZhou SIDU chemical Co., Ltd. | 0519-81291281 18015082300 | siduchem@hotmail.com | China | 274 | 62 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Shanghai Hekang Biotechnology Co., Ltd. | 17721021104 18939837085 | 2880152141@qq.com | China | 1840 | 55 |
View Latest Price from 3-Pyridinemethanol,alpha,6-dimethyl-(6CI,9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-12 | 5-(1-HYDROXYETHYL)-2-METHYLPYRIDINE
100189-16-0
|
$1.00 | 1KG | 99% | 1ton | Career Henan Chemical Co |
-
- 5-(1-HYDROXYETHYL)-2-METHYLPYRIDINE
100189-16-0
- $1.00
- 99%
- Career Henan Chemical Co
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