4-BROMO-3,5-DIMETHYL-1H-PYRROLE-2-CARBALDEHYDE
- CAS No.
- 89909-51-3
- Chemical Name:
- 4-BROMO-3,5-DIMETHYL-1H-PYRROLE-2-CARBALDEHYDE
- Synonyms
- 4-Bromo-3,5-dimethylpyrrole-2-carboxaldehyde;4-BROMO-3,5-DIMETHYL-1H-PYRROLE-2-CARBALDEHYDE;1H-Pyrrole-2-carboxaldehyde, 4-bromo-3,5-dimethyl-
- CBNumber:
- CB9136492
- Molecular Formula:
- C7H8BrNO
- Molecular Weight:
- 202.05
- MDL Number:
- MFCD08234561
- MOL File:
- 89909-51-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4-BROMO-3,5-DIMETHYL-1H-PYRROLE-2-CARBALDEHYDE price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 4255DF | 4-Bromo-3,5-dimethyl-1H-pyrrole-2-carbaldehyde | 89909-51-3 | 100mg | $103 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0142860 | 4-BROMO-3,5-DIMETHYL-1H-PYRROLE-2-CARBALDEHYDE 98.00% | 89909-51-3 | 5MG | $497.29 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H15-9-07 | 4-Bromo-3,5-dimethyl-1H-pyrrole-2-carbaldehyde | 89909-51-3 | 2g | $1515 | 2021-12-16 | Buy |
| Ambeed | A163271 | 4-Bromo-3,5-dimethyl-1H-pyrrole-2-carbaldehyde 95+% | 89909-51-3 | 5g | $500 | 2021-12-16 | Buy |
| Ambeed | A163271 | 4-Bromo-3,5-dimethyl-1H-pyrrole-2-carbaldehyde 95+% | 89909-51-3 | 100mg | $35 | 2021-12-16 | Buy |
4-BROMO-3,5-DIMETHYL-1H-PYRROLE-2-CARBALDEHYDE Chemical Properties,Uses,Production
Synthesis
2199-58-8
89909-51-3
General procedure 6: 3,5-dimethyl-2-pyrrolecarboxaldehyde (1 eq.) was suspended or dissolved in carbon tetrachloride (CCl4) under argon protection, followed by the addition of N-bromosuccinimide (NBS, 1.05 eq.) and benzoyl peroxide (0.025 eq.). The reaction mixture was heated to reflux and the reaction progress was monitored by liquid chromatography-mass spectrometry (LC/MS). Upon completion of the reaction, the crude product was cooled to room temperature and further cooled in an ice bath. If a precipitate formed, it was filtered and the product was purified by fast column chromatography. If no precipitate was formed, the solvent was removed under reduced pressure and the crude product was similarly purified by fast column chromatography. Preparation 23: The synthesis of 4-bromo-3,5-dimethyl-1H-pyrrole-2-carboxaldehyde was carried out according to General Method 6, specifically using the reaction of 3,5-dimethyl-1H-pyrrole-2-carboxaldehyde (8 g, 65 mmol), NBS (12.16 g, 68.3 mmol) and benzoyl peroxide (394 mg, 1.63 mmol) in carbon tetrachloride (300 mL). Purification gave 11.9 g of 4-bromo-3,5-dimethyl-1H-pyrrole-2-carbaldehyde as a dark solid in 92% yield.1H NMR (DMSO-d6) δ 12.06 (broad peak, 1H), 9.50 (single peak, 1H), 2.22 (single peak, 3H), 2.19 (single peak, 3H).
References
[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 17, p. 5412 - 5414
[2] Patent: WO2005/58309, 2005, A1. Location in patent: Page/Page column 62
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7286 - 7309
4-BROMO-3,5-DIMETHYL-1H-PYRROLE-2-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
4-BROMO-3,5-DIMETHYL-1H-PYRROLE-2-CARBALDEHYDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 4000 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 13681763483 | product02@bidepharm.com | China | 42446 | 60 |
| Shijiazhuang Jing Kang Technology Co.Ltd. | 13933818572 | 1519554262@qq.com | China | 1785 | 58 |
| Aikon International Limited | 025-66061636 18013972705 | qqyang@aikonchem.com | China | 15815 | 58 |
| Wuxi Kehua Biological Technology Co., Ltd. | 0510-86838766 | 2258830676@qq.com | China | 4717 | 58 |
