cycloastragenol
- CAS No.
- 84605-18-5
- Chemical Name:
- cycloastragenol
- Synonyms
- cas 84605-18-5;Cyclogalegigenin;Cycloastrageno;Cyclogalegenin;(3beta,6alpha,16beta,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol;Cyclogalagenin;Cyclogalgeginin;Cycloastragenol, >98%;cas 84605-18-5 78574-94-4;Cyclogalegenin (Standard)
- CBNumber:
- CB91378734
- Molecular Formula:
- C30H50O5
- Molecular Weight:
- 490.71
- MDL Number:
- MFCD11618124
- MOL File:
- 84605-18-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >220°C (dec.) |
|---|---|
| Boiling point | 617.2±55.0 °C(Predicted) |
| Density | 1.20 |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly) |
| form | Solid |
| pka | 14.57±0.29(Predicted) |
| color | White |
| InChIKey | WENNXORDXYGDTP-LMDVAILRNA-N |
| SMILES | C1C[C@]23C[C@@]42CC[C@]2(C)[C@@H]([C@]5(C)CC[C@H](C(C)(C)O)O5)[C@@H](O)C[C@@]2(C)[C@@H]4C[C@H](O)[C@H]3C(C)(C)[C@H]1O |&1:2,4,7,9,10,14,20,23,25,27,29,33,r| |
| FDA UNII | X37D9F2L0V |
cycloastragenol price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11722 | Cycloastragenol ≥98% | 84605-18-5 | 25mg | $28 | 2026-04-30 | Buy |
| Cayman Chemical | 11722 | Cycloastragenol ≥98% | 84605-18-5 | 50mg | $50 | 2026-04-30 | Buy |
| Cayman Chemical | 11722 | Cycloastragenol ≥98% | 84605-18-5 | 100mg | $77 | 2026-04-30 | Buy |
| Cayman Chemical | 11722 | Cycloastragenol ≥98% | 84605-18-5 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 11722 | Cycloastragenol ≥98% | 84605-18-5 | 5mg | $93 | 2024-03-01 | Buy |
cycloastragenol Chemical Properties, Uses, Production
Description
Cycloastragenol (TA-65), a small-triterpenoid purified from the root of an Asian medicinal herb, has currently received particular attention for its potential to regulate transcription of telomerase. TA-65 is capable to increase average telomere length and to decrease the percentage of critically short telomeres and DNA damage in MEFs that harbor critically short telomeres. The effects on telomerase appear to be in common with other triterpenoid saponins (ie, ginsenosides RG1 and Rg3). These compounds at concentrations from 1 to 20 μM were reported to protect against IL-1β-, H2O2-, and tert-butylhydroperoxide-induced senescence in human chondrocytes, endothelial progenitor cells and fibroblasts, respectively.
Biological Activity
Cycloastragenol, the aglycone derivative of astragaloside A, can be found in various species of Astragalus and is reported to activate telomerase. It has been shown to slow telomere loss, increase replicative capacity, and improve immune function in CD8+ T lymphocytes from HIV-1-infected patients.
Laboratory Procedures
Cycloastragenol is supplied as a crystalline solid. A stock solution may be made by dissolving the cycloastragenol in the solvent of choice. Cycloastragenol is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of cycloastragenol in these solvents is approximately 10, 3, and 25 mg/ml, respectively.
Cycloastragenol is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, cycloastragenol should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Cycloastragenol has a solubility of approximately 0.25 mg/ml in a 1:8 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Chemical Properties
Derived from the dried root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, a plant of the Leguminosae family
Uses
Cycloastragenol is an aglycone derivative of astragaloside IV found in the root of Korean Astragalus membranaceus.
Definition
ChEBI: A sapogenin that is the aglycone derivative of astragaloside IV, a major saponin extracted from the root of Astragalus membranaceus.
cycloastragenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Weifang Huazhi Biological Technology Co., Ltd. | 17388075642 13815430202 | sale02@cqherb.com | China | 50 | 58 |
| Jiangsu Yongjian Pharmaceutical Technology Co., Ltd | 17701422015 | 3582572959@qq.com | China | 994 | 58 |
| Hubei Danding Pharmaceutical Technology Co., Ltd | 17701422019 17701422019 | 181646821@qq.com | China | 2421 | 58 |
| Xi 'an Xinmengchen Biotechnology Co., LTD | 15002922985 | 511325867@qq.com | China | 305 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Shenzhen Sungening Bio-Tech Co., Ltd | +86-0755-89668383 | sales@sungening.com | China | 1319 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
Related articles
- Cycloastragenol: pharmacokinetics, activities and side effects
- Cycloastragenol shows potential for diverse health applications but requires further study for safety.
- Nov 23,2023
- What is cycloastragenol?
- Cycloastragenol is isolated from Astragalus species.
- Aug 20,2021
- Pharmacological Effects of Cycloastragenol
- Cycloastragenol (CAG), an aglycone of astragaloside IV, is a triterpenoid saponin compound and a hydrolysis product of the mai....
- Oct 28,2019
View Latest Price from cycloastragenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | Cycloastragenol
84605-18-5
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-17 | Cycloastragenol
84605-18-5
|
1KG | 99% | 5,000KG | Hangzhou Hyper Chemicals Limited | ||
 |
2026-07-19 | Cycloastragenol
84605-18-5
|
100Gram | 99% | 100kg/month | GIHI CHEMICALS CO.,LIMITED |
-
- Cycloastragenol
84605-18-5
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Cycloastragenol
84605-18-5
- 99%
- Hangzhou Hyper Chemicals Limited
-
- Cycloastragenol
84605-18-5
- $0.00
- 99%
- GIHI CHEMICALS CO.,LIMITED
