RET/TRKA-IN-1

RET/TRKA-IN-1 structure

CAS No.: 3048634-52-9

Chemical Name:: RET/TRKA-IN-1

Synonyms: RET/TRKA-IN-1;Benzeneacetamide, N-[3-(1,1-dimethylethyl)-1-methyl-1H-pyrazol-5-yl]-4-[[7-(1-methyl-1H-pyrazol-4-yl)-9H-pyrimido[4,5-b]indol-4-yl]amino]-

CBNumber:: CB914907882

Molecular Formula:: C30H31N9O

Molecular Weight:: 533.63

MDL Number:

MOL File:: 3048634-52-9.mol

Last updated:2025-04-18 09:53:05

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RET/TRKA-IN-1 Properties

Boiling point	855.4±65.0 °C(predicted)
Density	1.34±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	12.38±0.50(predicted)

RET/TRKA-IN-1 Chemical Properties, Uses, Production

Uses

RET/TRKA-IN-1 (Compound 13) is a dual inhibitor for RET (IC50=0.375 μM) and TRKA. RET/TRKA-IN-1 inhibits cell viability of LC-2 and KM12, with GI50 of 0.72 and 0.25 μM. RET/TRKA-IN-1 arrests the cell cycle at G1 phase[1].

References

[1] Acharya B, et al., Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors. Bioorg Med Chem. 2024 May 15;106:117749. DOI:10.1016/j.bmc.2024.117749

RET/TRKA-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

RET/TRKA-IN-1 Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol	400-821-0310 15002144251	xuexiang.shao@tsbiochem.com	China	29128	58

Supplier	Advantage
TargetMol	58

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RET/TRKA-IN-1 Benzeneacetamide, N-[3-(1,1-dimethylethyl)-1-methyl-1H-pyrazol-5-yl]-4-[[7-(1-methyl-1H-pyrazol-4-yl)-9H-pyrimido[4,5-b]indol-4-yl]amino]- 3048634-52-9