3-CHLORO-5-FLUOROPHENYLACETONITRILE
- CAS No.
- 493038-93-0
- Chemical Name:
- 3-CHLORO-5-FLUOROPHENYLACETONITRILE
- Synonyms
- SALOR-INT L301035-1EA;3-Chloro-5-fluorophenylacetoni;3-CHLORO-5-FLUOROBENZYL CYANIDE;3-CHLORO-5-FLUOROPHENYLACETONITRILE;3-Chloro-5-fluorobenzeneacetonitrile;3-Chloro-5-fluorophenylacetonitrile,97%;Benzeneacetonitrile, 3-chloro-5-fluoro-;2-(3-Chloro-5-fluorophenyl)acetonitrile;3-Chloro-5-fluorophenyl acetonitrile,98%
- CBNumber:
- CB9170634
- Molecular Formula:
- C8H5ClFN
- Molecular Weight:
- 169.58
- MDL Number:
- MFCD04038259
- MOL File:
- 493038-93-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Chloro-5-fluorobenzyl Cyanide >98.0%(GC) | C3330 | 1g | $45 |
| 3-Chloro-5-fluorobenzyl Cyanide >98.0%(GC) | C3330 | 5g | $176 |
| 3-Chloro-5-fluorophenylacetonitrile ≥95% | PC0331 | 1g | $24 |
| 3-Chloro-5-fluorophenylacetonitrile ≥95% | PC0331 | 5g | $100 |
| 3-Chloro-5-fluorophenylacetonitrile ≥95% | PC0331 | 25g | $440 |
| Boiling point | 244.7±25.0 °C(Predicted) |
|---|---|
| Density | 1.286±0.06 g/cm3(Predicted) |
| refractive index | 1.523-1.525 |
| storage temp. | Sealed in dry,Room Temperature |
| form | clear liquid |
| color | Colorless to Light yellow to Light orange |
| Water Solubility | Not miscible or difficult to mix with water. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H311-H315-H319-H331 | |||||||||
| Precautionary statements | P280h-P305+P351+P338-P309-P310 | |||||||||
| Hazard Codes | Xn,T | |||||||||
| Risk Statements | 36/37/38-20/21/22-36/37/39 | |||||||||
| Safety Statements | 36/37/39-26 | |||||||||
| RIDADR | UN 3276 6.1/PG III | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2926907090 | |||||||||
| NFPA 704 |
|
3-CHLORO-5-FLUOROPHENYLACETONITRILE price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C3330 | 3-Chloro-5-fluorobenzyl Cyanide >98.0%(GC) | 493038-93-0 | 1g | $45 | 2026-04-30 | Buy |
| TCI Chemical | C3330 | 3-Chloro-5-fluorobenzyl Cyanide >98.0%(GC) | 493038-93-0 | 5g | $176 | 2026-04-30 | Buy |
| Apolloscientific | PC0331 | 3-Chloro-5-fluorophenylacetonitrile ≥95% | 493038-93-0 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC0331 | 3-Chloro-5-fluorophenylacetonitrile ≥95% | 493038-93-0 | 5g | $100 | 2026-06-04 | Buy |
| Apolloscientific | PC0331 | 3-Chloro-5-fluorophenylacetonitrile ≥95% | 493038-93-0 | 25g | $440 | 2026-06-04 | Buy |
3-CHLORO-5-FLUOROPHENYLACETONITRILE Chemical Properties,Uses,Production
Chemical Properties
clear yellow liquid
Uses
It is employed as a intermediates for pharmaceutical.
Synthesis
773837-37-9
493024-39-8
493038-93-0
3-Chloro-5-fluorobenzyl bromide (58.23 g, 260 mmol) and acetic acid (5.35 mL, 93.6 mmol) were dissolved in toluene (260 mL). Aqueous sodium cyanide (195 mL, 48.57 g, 990 mmol) and tributylbenzyl ammonium chloride (5.68 g, 18.2 mmol) were added slowly and dropwise with stirring. The reaction mixture was stirred continuously at room temperature for 4 hours. After completion of the reaction, the organic layer was separated and washed sequentially with deionized water (200 mL) and saturated sodium chloride solution (200 mL). The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product obtained was purified by basic silica gel column chromatography using hexane-ethyl acetate (4:1, v/v) as eluent to give 3-chloro-5-fluorophenylacetonitrile (44.89 g, 100% yield) as a brown oil. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 3.74 (2H, s), 6.99 (1H, d, J = 8.7 Hz), 7.05-7.13 (1H, m), 7.15 (1H, s).
References
[1] Patent: EP2530078, 2012, A1. Location in patent: Page/Page column 118
3-CHLORO-5-FLUOROPHENYLACETONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
3-CHLORO-5-FLUOROPHENYLACETONITRILE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 9976 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Changzhou Anxuan Chemical Co., Ltd | +86-0519-89882563 +86-18961279162 | andy@anxuanchem.com | China | 4327 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
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