3-Chloro-5-fluorophenylacetonitrile
- CAS No.
- 493038-93-0
- Chemical Name:
- 3-Chloro-5-fluorophenylacetonitrile
- Synonyms
- SALOR-INT L301035-1EA;3-Chloro-5-fluorophenylacetoni;3-CHLORO-5-FLUOROBENZYL CYANIDE;3-Chloro-5-fluorophenylacetonitrile;3-Chloro-5-fluorobenzeneacetonitrile;3-Chloro-5-fluorophenylacetonitrile,97%;Benzeneacetonitrile, 3-chloro-5-fluoro-;2-(3-Chloro-5-fluorophenyl)acetonitrile;3-Chloro-5-fluorophenyl acetonitrile,98%
- CBNumber:
- CB9170634
- Molecular Formula:
- C8H5ClFN
- Molecular Weight:
- 169.58
- MDL Number:
- MFCD04038259
- MOL File:
- 493038-93-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 244.7±25.0 °C(Predicted) |
|---|---|
| Density | 1.286±0.06 g/cm3(Predicted) |
| refractive index | 1.523-1.525 |
| storage temp. | Sealed in dry,Room Temperature |
| form | clear liquid |
| color | Colorless to Light yellow to Light orange |
| Water Solubility | Not miscible or difficult to mix with water. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H311-H315-H319-H331 | |||||||||
| Precautionary statements | P280h-P305+P351+P338-P309-P310 | |||||||||
| Hazard Codes | Xn,T | |||||||||
| Risk Statements | 36/37/38-20/21/22-36/37/39 | |||||||||
| Safety Statements | 36/37/39-26 | |||||||||
| RIDADR | UN 3276 6.1/PG III | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2926907090 | |||||||||
| NFPA 704 |
|
3-Chloro-5-fluorophenylacetonitrile price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C3330 | 3-Chloro-5-fluorobenzyl Cyanide >98.0%(GC) | 493038-93-0 | 1g | $45 | 2026-04-30 | Buy |
| TCI Chemical | C3330 | 3-Chloro-5-fluorobenzyl Cyanide >98.0%(GC) | 493038-93-0 | 5g | $176 | 2026-04-30 | Buy |
| Apolloscientific | PC0331 | 3-Chloro-5-fluorophenylacetonitrile ≥95% | 493038-93-0 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC0331 | 3-Chloro-5-fluorophenylacetonitrile ≥95% | 493038-93-0 | 5g | $100 | 2026-06-04 | Buy |
| Apolloscientific | PC0331 | 3-Chloro-5-fluorophenylacetonitrile ≥95% | 493038-93-0 | 25g | $440 | 2026-06-04 | Buy |
3-Chloro-5-fluorophenylacetonitrile Chemical Properties, Uses, Production
Chemical Properties
clear yellow liquid
Uses
It is employed as a intermediates for pharmaceutical.
Synthesis
773837-37-9
493024-39-8
493038-93-0
3-Chloro-5-fluorobenzyl bromide (58.23 g, 260 mmol) and acetic acid (5.35 mL, 93.6 mmol) were dissolved in toluene (260 mL). Aqueous sodium cyanide (195 mL, 48.57 g, 990 mmol) and tributylbenzyl ammonium chloride (5.68 g, 18.2 mmol) were added slowly and dropwise with stirring. The reaction mixture was stirred continuously at room temperature for 4 hours. After completion of the reaction, the organic layer was separated and washed sequentially with deionized water (200 mL) and saturated sodium chloride solution (200 mL). The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product obtained was purified by basic silica gel column chromatography using hexane-ethyl acetate (4:1, v/v) as eluent to give 3-chloro-5-fluorophenylacetonitrile (44.89 g, 100% yield) as a brown oil. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 3.74 (2H, s), 6.99 (1H, d, J = 8.7 Hz), 7.05-7.13 (1H, m), 7.15 (1H, s).
References
[1] Patent: EP2530078, 2012, A1. Location in patent: Page/Page column 118
3-Chloro-5-fluorophenylacetonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
3-Chloro-5-fluorophenylacetonitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
View Latest Price from 3-Chloro-5-fluorophenylacetonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-31 | 3-CHLORO-5-FLUOROPHENYLACETONITRILE
493038-93-0
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd |
-
- 3-CHLORO-5-FLUOROPHENYLACETONITRILE
493038-93-0
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
