3-Oxo-3-pyridin-4-yl-propionitrile
- CAS No.
- 23821-37-6
- Chemical Name:
- 3-Oxo-3-pyridin-4-yl-propionitrile
- Synonyms
- 4-(2-Cyanoacetyl)pyridine;b-oxo-4-Pyridinepropanenitrile;4-Pyridinepropanenitrile, β-oxo-;Beta-oxo-4-pyridinepropanenitrile;3-Oxo-3-(4-pyridyl)propanenitrile;3-OXO-3-PYRIDIN-4-YLPROPANENITRILE;3-OXO-4-PYRIDIN-3-YL-PROPIONITRILE;3-Oxo-3-pyridin-4-yl-propionitrile;3-Oxo-3-(4-pyridinyl)propanenitrile;3-oxo-3-(yridine-4-yl)propanenitrile
- CBNumber:
- CB9173983
- Molecular Formula:
- C8H6N2O
- Molecular Weight:
- 146.15
- MDL Number:
- MFCD06656807
- MOL File:
- 23821-37-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P260-P280-P271 |
| Hazard Codes | T,Xn |
| Risk Statements | 22-37/38-41 |
| Safety Statements | 26-39 |
| HS Code | 2933399990 |
3-Oxo-3-pyridin-4-yl-propionitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 286290 | 3-Oxo-3-pyridin-4-yl-propionitrile Asreported | 23821-37-6 | 250mg | $333 | 2026-06-03 | Buy |
| Usbiological | 286290 | 3-Oxo-3-pyridin-4-yl-propionitrile Asreported | 23821-37-6 | 500mg | $496 | 2026-06-03 | Buy |
| Usbiological | 286290 | 3-Oxo-3-pyridin-4-yl-propionitrile Asreported | 23821-37-6 | 1g | $674 | 2026-06-03 | Buy |
| Usbiological | 286290 | 3-Oxo-3-pyridin-4-yl-propionitrile Asreported | 23821-37-6 | 2g | $914 | 2026-06-03 | Buy |
| Apolloscientific | OR2995 | 3-Oxo-3-(pyridin-4-yl)propanenitrile 95% | 23821-37-6 | 250mg | $86 | 2026-06-04 | Buy |
3-Oxo-3-pyridin-4-yl-propionitrile Chemical Properties, Uses, Production
Synthesis
2459-09-8
75-05-8
23821-37-6
3-Oxo-3-(4-pyridyl)propionitrile was synthesized from methyl isonicotinate and acetonitrile according to the improved scheme of route A1. The procedure was as follows: 3 g (22 mmol) of methyl isonicotinate was dissolved in 30 mL of anhydrous toluene under nitrogen protection, and 1.75 g (44 mmol) of 50-60% NaH (dispersed in mineral oil) was slowly added. Subsequently, 5.39 mL (103 mmol) of dry acetonitrile was added slowly and dropwise at 90 °C. The reaction mixture was heated and refluxed for 18 hours, during which the product precipitated as sodium salt. After completion of the reaction, it was cooled to room temperature and the solid product was collected by filtration. The solid was dissolved in water, the pH was adjusted to 5-6 with 6N HCl solution and the product was extracted with dichloromethane (DCM). The aqueous phase was again pH adjusted to 4-5 and a secondary extraction with DCM was performed to recover more product. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give the crude product in 58% yield. The crude product can be used directly in the subsequent reaction.
References
[1] Patent: WO2008/87529, 2008, A1. Location in patent: Page/Page column 113
[2] Patent: WO2007/98826, 2007, A2. Location in patent: Page/Page column 47-48
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 24, p. 6890 - 6892
[4] Patent: WO2006/84015, 2006, A2. Location in patent: Page/Page column 86-87
[5] Patent: WO2010/9290, 2010, A1. Location in patent: Page/Page column 143-144
3-Oxo-3-pyridin-4-yl-propionitrile Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai AmasPharm Co., Ltd. | 021-54540637 18621091017 | sales@amaspharm.com | China | 787 | 62 |
| ZhengZhou HuaWen Chemical Co.Ltd | 0370-2785118 17550508557 | 675141927@qq.com | China | 3201 | 55 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2297 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Shanghai potentpharm CO.,Ltd | 13524892556 | sales-cn@potentpharm.com | China | 1011 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 |
View Latest Price from 3-Oxo-3-pyridin-4-yl-propionitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 3-OXO-3-PYRIDIN-4-YL-PROPIONITRILE
23821-37-6
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- 3-OXO-3-PYRIDIN-4-YL-PROPIONITRILE
23821-37-6
- $1.00
- 98%
- Career Henan Chemical Co
