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ML-7 HYDROCHLORIDE

ML-7 HYDROCHLORIDE Structure
ML-7 HYDROCHLORIDE structure
CAS No.
110448-33-4
Chemical Name:
ML-7 HYDROCHLORIDE
Synonyms
ML-7;CS-755;ML;ML 7;ML-7, HCl;ML-7 HCl ，S8388;ML-7 HYDROCHLORIDE;ML7;ML 7 HYDROCHLORIDE;ML 7 hydrochloride, >=98%;ML-7 hydrochloride hydrate;ML-7 hydrochloride, 10 mM in DMSO
CBNumber:
CB9183931
Molecular Formula:
C15H18ClIN2O2S
Molecular Weight:
452.74
MDL Number:
MFCD00065524
MOL File:
110448-33-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
ML-7 powder I2764 5mg $180
ML-7, Hydrochloride 475880 1mg $217
ML-7 (hydrochloride) ≥95% 11801 5mg $68
ML-7 (hydrochloride) ≥95% 11801 10mg $106
ML-7 (hydrochloride) ≥95% 11801 25mg $216
More product size
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ML-7 HYDROCHLORIDE Properties

Melting point 246-249°C dec.
storage temp. -20°C
solubility insoluble in EtOH; ≥15.95 mg/mL in DMSO; ≥8.82 mg/mL in H2O with gentle warming and ultrasonic
form powder
color white
InChI 1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChIKey KDDALCDYHZIZMH-UHFFFAOYSA-N
SMILES Cl.Ic1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
Storage Class 11 - Combustible Solids

ML-7 HYDROCHLORIDE price More Price(76)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I2764 ML-7 powder 110448-33-4 5mg $180 2026-04-30 Buy
Sigma-Aldrich 475880 ML-7, Hydrochloride 110448-33-4 1mg $217 2026-04-30 Buy
Cayman Chemical 11801 ML-7 (hydrochloride) ≥95% 110448-33-4 5mg $68 2026-04-30 Buy
Cayman Chemical 11801 ML-7 (hydrochloride) ≥95% 110448-33-4 10mg $106 2026-04-30 Buy
Cayman Chemical 11801 ML-7 (hydrochloride) ≥95% 110448-33-4 25mg $216 2026-04-30 Buy
Product number Packaging Price Buy
I2764 5mg $180 Buy
475880 1mg $217 Buy
11801 5mg $68 Buy
11801 10mg $106 Buy
11801 25mg $216 Buy

ML-7 HYDROCHLORIDE Chemical Properties,Uses,Production

Description

ML-7 inhibits smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 μM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. It exhibits a 10-fold more potent inhibition of MLCK than its parent compound ML-9 .

Chemical Properties

Off-White to Yellow Fine Crystalline Solid

Uses

A potent and selective inhibitor of myosin light chain kinase.

Uses

ML-7 has been used as a myosin light chain kinase (MLCK) inhibitor in various experiments.

Biochem/physiol Actions

Selective myosin light chain kinase inhibitor.

Synthesis

It is synthesized in two steps. 1) Synthesis of 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine: A toluene solution of homopiperazine reacts with a solution of 5-iodo-1-naphthalenesulfonyl chloride. After filtration, the filtrate is washed with water. The organic phase is purified over a silica gel pad. The resulting solid is crystallized from isopropanol and dried to give the product. 2) Preparation of the hydrochloride (ML-7 HYDROCHLORIDE): The product from step 1 is dissolved in isopropanol by heating. After cooling, 6N HCl is added. The mixture is cooled and filtered. The solid is crystallized from water, filtered, washed, and vacuum-dried to yield the title hydrochloride.

in vitro

rats with myocardial infarction were intravenously infused with rhnrg-1. the cmlck expression and phosphorylated mlc-2v were up-regulated in rat treated with rhnrg-1 significantly. moreover, the restoration of rhnrg-1-induced sarcomeric organization in serum-free cultured neonatal rat cardiomyocytes with rhnrg-1 was inhibited by ml-7 [1].

in vivo

administration of ml-7 from 10 min before ischemia to the first 10 min of reperfusion led to a significant recovery of heart contractility. gel analyses of two-dimensional electrophoresis revealed eight proteins with decreased levels in i/r hearts. six proteins involved in energy metabolism, which were cytochrome b-c1 complex subunit 1, atp synthase beta subunit, cytochrome c oxidase subunit, mitochondrial nadhdehydrogenase, nadhdehydrogenase iron-sulfur protein 8, and succinyl-coa ligase subunit. the other two protein levels decreased in i/r hearts, which were peroxiredoxin-2 and tubulin. in addition, ml-7 treatment increased the level of succinyl-coa ligase, which was a key enzyme involved in the citric acid cycle [2].

storage

room temperature (desiccate)

References

[1] gu x,liu x,xu d,li x,yan m,qi y,yan w,wang w,pan j,xu y,xi b,cheng l,jia j,wang k,ge j,zhou m. cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin. cardiovasc res.2010 nov 1;88(2):334-43.
[2] lin hb,cadete vj,sawicka j,wozniak m,sawicki g. effect of the myosin light chain kinase inhibitor ml-7 on the proteome of hearts subjected to ischemia-reperfusion injury. j proteomics.2012 sep 18;75(17):5386-95.

ML-7 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

ML-7 HYDROCHLORIDE Suppliers

Global( 172)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32997 60
TianYuan Pharmaceutical CO.,LTD 		+86-755-23284190 13684996853 sales@tianpharm.com CHINA 304 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63645 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9897 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
Henan Aochuang Chemical Co.,Ltd. 		+86-0371-63689365 +8618638391208 sales@aochuangchem.com China 9322 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38999 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TianYuan Pharmaceutical CO.,LTD 		58
Alchem Pharmtech,Inc. 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
InvivoChem 		58
Henan Aochuang Chemical Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58

View Lastest Price from ML-7 HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ML-7 hydrochloride pictures 2026-07-27 ML-7 hydrochloride
110448-33-4
 $42.00-152.00 99.61% 10g TargetMol Chemicals Inc.
ML-7 HYDROCHLORIDE pictures 2025-04-04 ML-7 HYDROCHLORIDE
110448-33-4
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
ML-7 HYDROCHLORIDE pictures 2019-12-24 ML-7 HYDROCHLORIDE
110448-33-4
 $1.00 1g 99.99% 200kg Career Henan Chemical Co

ML-7 HYDROCHLORIDE Spectrum

ML-7 HYDROCHLORIDE(110448-33-4)1HNMR

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ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem ML;ML 7 CS-755 ML7;ML 7 HYDROCHLORIDE 1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HCL 1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HYDROCHLORIDE 1-(5-IODONAPHTHALENE-1-SULFONYL)HOMOPIPERAZINE, HCL 1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE ML-7 1-(5-iodonaphthalene-1-sulfonyl)-1H-*hexahydro-1, ML-7, HCl 1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-*HEX AHYDRO-1,4- 1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine, hyd Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride 1-((5-Iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride ML 7 hydrochloride, >=98% Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine Monohydrochloride 1H-1,4-Diazepine, hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-, Monohydrochloride ML-7 HYDROCHLORIDE ML-7 hydrochloride hydrate 1H-1,4-Diazepine, hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-, hydrochloride (1:1) ML7, myosin light chain kinase inhibitor ML-7 hydrochloride, 10 mM in DMSO ML-7 HCl ，S8388 ML-7 Hydrochloride, 98%, a naphthalene sulphonamide derivative 110448-33-4 C15H18ClIN2O2S C15H17N2O2ISHCl C15H17IN2O2SHCl Serine/Threonine Kinase Inhibitors Myosin Light Chain Kinase (MLCK) Kinase/Phosphatase Biology BioChemical Cell Biology Cell Signaling and Neuroscience All Inhibitors Inhibitors Protein Kinase Inhibitors and Activators