ML365
- CAS No.
- 947914-18-3
- Chemical Name:
- ML365
- Synonyms
- ML365;CS-2437;ML365, 10 mM in DMSO;ML-365; ML365; ML 365;2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide;2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide;Benzamide, 2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]-;2-Methoxy-N-(3-(3-methylbenzcarboxcarboxcarboxamido)phenyl)-benzamide;KcsA,aldosterone,diseases,Inhibitor,autoimmune,channels,ML365,secretion,TASK,ML-365,potassium,Potassium Channel,TWIK-related,pharmacological,acid-sensitive,hypertension,inhibit,ML 365,CNS,tool
- CBNumber:
- CB92715655
- Molecular Formula:
- C22H20N2O3
- Molecular Weight:
- 360.41
- MDL Number:
- MFCD09204310
- MOL File:
- 947914-18-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| ML365 ≥98% (HPLC) | SML2643 | 5 mg | $104 |
| ML365 ≥98% (HPLC) | SML2643 | 25 mg | $415 |
| ML-365 ≥98% | 24666 | 1mg | $41 |
| ML-365 ≥98% | 24666 | 5mg | $128 |
| ML-365 ≥98% | 24666 | 10mg | $215 |
| More product size | |||
| Boiling point | 429.9±40.0 °C(Predicted) |
|---|---|
| Density | 1.253±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility |
DMSO:72.0(Max Conc. mg/mL);199.77(Max Conc. mM) Ethanol:18.0(Max Conc. mg/mL);49.94(Max Conc. mM) |
| form | Powder |
| pka | 13.21±0.70(Predicted) |
| color | White to off-white |
| InChI | 1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26) |
| InChIKey | UTAJHKSGYJSZBR-UHFFFAOYSA-N |
| SMILES | N(c2cc(ccc2)NC(=O)c3cc(ccc3)C)C(=O)c1c(cccc1)OC |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 13 - Non Combustible Solids |
ML365 price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2643 | ML365 ≥98% (HPLC) | 947914-18-3 | 5 mg | $104 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2643 | ML365 ≥98% (HPLC) | 947914-18-3 | 25 mg | $415 | 2026-04-30 | Buy |
| Cayman Chemical | 24666 | ML-365 ≥98% | 947914-18-3 | 1mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 24666 | ML-365 ≥98% | 947914-18-3 | 5mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 24666 | ML-365 ≥98% | 947914-18-3 | 10mg | $215 | 2026-04-30 | Buy |
ML365 Chemical Properties,Uses,Production
Uses
ML 365 acts as a potent and selective ASK-1 potassium channel blocker used in the regulation of cell membrane potential. This activity further modulates cell immune response, hormone changes, and neuronal function leading to various applications.
Biological Activity
Orignially characterized as an mGluR5 negative allosteric modulator (IC50 = 1.35 μM, Emax = 3.82% of Glu Emax; r at mGluR5 HEK293A cells), ML365 is now better known as selective two-pore potassium (K2P) channel TASK1 (K2P3.1; KCNK3) inhibitor with 100- and 62-fold selectivity over TASK3 (K2p9.1; KCNK9), respectively, by thellium flux (r at TASK1/TASK3 CHO cell IC50 = 4/390 nM) and QPatch assay (r at TASK1/TASK3 CHO cell IC50 = 16/990 nM). ML365 is employed in the range from 40 nM to 20 μM. Selective TASK1 blockage is achieved at the lower end of the concentration range, while TASK3 activity can also be inhibited at the high end of the range.
storage
Store at +4°C
ML365 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | info@chemia-pharm.com | CHINA | 310 | 58 | |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +86-18051384581 | sales@chemhifuture.com | China | 3123 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11674 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +86-18327326525 | masar@topule.com | China | 8433 | 58 |
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