3-Nitrosalicylaldehyde
- CAS No.
- 5274-70-4
- Chemical Name:
- 3-Nitrosalicylaldehyde
- Synonyms
- 2-HYDROXY-3-NITROBENZALDEHYDE;NSC 38026;AKOS B029850;3-nitrosalicaldehyde;3-NITROSALICYLALDEHYDE;LABOTEST-BB LT00939229;2-formyl-6-nitrophenolate;3-Nitrosalicylaldehyde>salicylaldehyde, 3-nitro-;3-Nitrosalicylaldehyde,98%
- CBNumber:
- CB9199158
- Molecular Formula:
- C7H5NO4
- Molecular Weight:
- 167.12
- MDL Number:
- MFCD00041874
- MOL File:
- 5274-70-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 105-109 °C(lit.) |
|---|---|
| Boiling point | 295.67°C (rough estimate) |
| Density | 1.5216 (rough estimate) |
| refractive index | 1.6280 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 5.07±0.24(Predicted) |
| form | Crystalline Powder |
| color | Yellow to brown |
| Water Solubility | slightly soluble |
| Sensitive | Air Sensitive |
| InChI | 1S/C7H5NO4/c9-4-5-2-1-3-6(7(5)10)8(11)12/h1-4,10H |
| InChIKey | NUGOTBXFVWXVTE-UHFFFAOYSA-N |
| SMILES | Oc1c(C=O)cccc1[N+]([O-])=O |
| CAS DataBase Reference | 5274-70-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzaldehyde, 2-hydroxy-3-nitro-(5274-70-4) |
| EPA Substance Registry System | Benzaldehyde, 2-hydroxy-3-nitro- (5274-70-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22-20/21/22 | |||||||||
| Safety Statements | 26-36-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29130000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Nitrosalicylaldehyde price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 527424 | 2-Hydroxy-3-nitrobenzaldehyde 98% | 5274-70-4 | 1g | $35.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 527424 | 2-Hydroxy-3-nitrobenzaldehyde 98% | 5274-70-4 | 5g | $53.5 | 2024-03-01 | Buy |
| TCI Chemical | N0823 | 3-Nitrosalicylaldehyde >98.0%(GC)(T) | 5274-70-4 | 1g | $71 | 2026-04-30 | Buy |
| TCI Chemical | N0823 | 3-Nitrosalicylaldehyde >98.0%(GC)(T) | 5274-70-4 | 5g | $192 | 2026-04-30 | Buy |
| Usbiological | 418232 | 2-Hydroxy-3-nitrobenzaldehyde | 5274-70-4 | 1g | $403 | 2026-06-03 | Buy |
3-Nitrosalicylaldehyde Chemical Properties, Uses, Production
Chemical Properties
yellow to brown crystalline powder
Uses
2-Hydroxy-3-nitrobenzaldehyde may be used in the synthesis of 5-acetyl-4-aryl-6-methyl-1,2,3,4-tetrahydro pyrimidine.
General Description
2-Hydroxy-3-nitrobenzaldehyde can be extracted from the leaves of Actephila merrilliana. Its molecule is planar. On reaction with dapsone, it affords a colorless solution.
Synthesis
90-02-8
5274-70-4
GENERAL METHOD: Salicylaldehyde (10 mmol) was mixed with urea nitrate (10 mmol) in acetonitrile-water solvent mixture (95:5, 5 ml, v/v) in a 25 ml round bottom flask. The reaction mixture was placed in a Milestone Start SYNTH microwave reactor and heated at 80°C for 40-50 min. Upon completion of the reaction, the reaction mixture was cooled to room temperature, quenched with water and extracted with dichloromethane. The organic phase was concentrated under reduced pressure and the residue was purified by silica gel column chromatography to afford the target product 3-nitrosalicylaldehyde. In all experiments, o-nitrosalicylaldehyde was selectively generated and no para-nitro-substituted by-products were detected. The resulting compounds were characterized by 1H NMR, 13C NMR, melting point determination (for solid samples), GC-MS analysis and comparison with standards.
References
[1] Chinese Chemical Letters, 2010, vol. 21, # 4, p. 403 - 406
[2] Synthetic Communications, 2011, vol. 41, # 20, p. 2985 - 2992
[3] Tetrahedron Letters, 2014, vol. 55, # 7, p. 1320 - 1322
[4] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 57-58
[5] Tetrahedron, 1969, vol. 25, p. 3251 - 3266
3-Nitrosalicylaldehyde Preparation Products And Raw materials
3-Nitrosalicylaldehyde Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 |
View Latest Price from 3-Nitrosalicylaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-02 | 3-Nitrosalicylaldehyde
5274-70-4
|
10mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-07-10 | 3-Nitrosalicylaldehyde
5274-70-4
|
$1.00 | 1ASSAYS | 98% | 1kg,2kg,100kg | Career Henan Chemical Co |
-
- 3-Nitrosalicylaldehyde
5274-70-4
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-Nitrosalicylaldehyde
5274-70-4
- $1.00
- 98%
- Career Henan Chemical Co
