3,4,5-Trifluoroaniline
- CAS No.
- 163733-96-8
- Chemical Name:
- 3,4,5-Trifluoroaniline
- Synonyms
- 3,4,5-Trifluoroanili;3,4,5-Trifluroaniline;3,4,5-TRIFLUOROANILINE;3,4,5-Trifluoroaniline98%;3,4,5-Trifluoroaniline 98%;3,4,5-Trifluoroaniline, 97+%;(3,4,5-trifluorophenyl)amine;Benzenamine, 3,4,5-trifluoro-;Benzenamine, 3,4,5-trifluoro- (9CI);3,4,5-Trifluoroaniline ISO 9001：2015 REACH
- CBNumber:
- CB9202308
- Molecular Formula:
- C6H4F3N
- Molecular Weight:
- 147.1
- MDL Number:
- MFCD00083522
- MOL File:
- 163733-96-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 61-64 °C (lit.) |
|---|---|
| Boiling point | 100.5°C (rough estimate) |
| Density | 1.3510 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 2.63±0.10(Predicted) |
| color | White to Almost white |
| Water Solubility | Soluble in methanol (almost transparency). Insoluble in water. |
| BRN | 4977254 |
| InChI | InChI=1S/C6H4F3N/c7-4-1-3(10)2-5(8)6(4)9/h1-2H,10H2 |
| InChIKey | SZRDJHHKIJHJHQ-UHFFFAOYSA-N |
| SMILES | C1(N)=CC(F)=C(F)C(F)=C1 |
| CAS DataBase Reference | 163733-96-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-41-38-21/22 | |||||||||
| Safety Statements | 26-36-36/37/39 | |||||||||
| RIDADR | UN2941 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214200 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3,4,5-Trifluoroaniline price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 559490 | 3,4,5-Trifluoroaniline 98% | 163733-96-8 | 5g | $50 | 2022-05-15 | Buy |
| Sigma-Aldrich | 559490 | 3,4,5-Trifluoroaniline 98% | 163733-96-8 | 1g | $51.6 | 2022-05-15 | Buy |
| TCI Chemical | T2355 | 3,4,5-Trifluoroaniline >98.0%(GC) | 163733-96-8 | 1g | $28 | 2026-04-30 | Buy |
| TCI Chemical | T2355 | 3,4,5-Trifluoroaniline >98.0%(GC) | 163733-96-8 | 5g | $79 | 2026-04-30 | Buy |
| Apolloscientific | PC7260B | 3,4,5-Trifluoroaniline 98% | 163733-96-8 | 5g | $21 | 2026-06-04 | Buy |
3,4,5-Trifluoroaniline Chemical Properties, Uses, Production
Synthesis
At room temperature, 300 mg (0.6 mmol) of the complex of 1,10-linphenanthroline and nickel dichloride hexahydrate, 8.01 g (122.4 mmol) of zinc powder, 13 mL of molten 1-butyl-3-methylimidazolium bromide, and 2.5 mL of H2O were added to a 25 mL three-necked flask. The mixture was stirred at 70 °C for 10 min. Then, 2.76 g (12.3 mmol) of pentafluoroacetanilide was added to the mixture. The reaction mixture was then heated and stirred at 70 °C for 2 h. The mixture was diluted with 10 mL of acetonitrile. The insoluble solids were removed by filtration. The filtrate was then washed with acetonitrile, and the solvent was evaporated. 3,4,5-Trifluoroacetanilide was stirred in hot ethyl acetate c (5 x 10 ml), and the combined organic compounds were evaporated under vacuum. The residue was mixed with 50 ml of H2O, and an aqueous sodium hydroxide solution was added to the mixture until the pH reached 13-14. The mixture was stirred for 1 hour, and the product was separated by distillation to obtain 3,4,5-trifluoroaniline. [Image: Synthesis of 3,4,5-trifluoroaniline]
Chemical Properties
pale brown crystalline powder
Uses
3,4,5-Trifluoroaniline and other halogenated anilines have been used to study Cytochrome P450 2E1/2A6-selective inhibition on metabolic activation of dimethylnitrosamine in human liver microsomes
General Description
3,4,5-Trifluoroaniline can be prepared from pentafluoroacetanilide, via catalytic hydrodefluorination.
3,4,5-Trifluoroaniline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Dalian Zhuorui Biological Technology Co. LTD | 13609862298 | yy7242701@163.com | China | 78 | 58 |
| Changzhou Xinda Biotechnology Co., Ltd | 0519-85519868 18915088878 | xiaoweng106108@163.com | China | 99 | 58 |
| Anstar Chemical (Group) Co.,Ltd. | 18053179586 | export@anstarchemical.com | China | 698 | 58 |
| Changzhou Anchor Biological Technology Co., Ltd | 0519-85519868 18915088878 | sales@ankerbio.com | China | 260 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Latest Price from 3,4,5-Trifluoroaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 3,4,5-Trifluoroaniline
163733-96-8
|
$8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2019-07-06 | 3,4,5-Trifluoroaniline
163733-96-8
|
$1.00 | 1kg | 99% | Career Henan Chemical Co |
-
- 3,4,5-Trifluoroaniline
163733-96-8
- $8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3,4,5-Trifluoroaniline
163733-96-8
- $1.00
- 99%
- Career Henan Chemical Co
