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5-Bromo-1,2,3-trifluorobenzene

5-Bromo-1,2,3-trifluorobenzene structure

CAS No.: 138526-69-9

Chemical Name:: 5-Bromo-1,2,3-trifluorobenzene

Synonyms: 3,4,5-TRIFLUOROBROMOBENZENE;1-BROMO-3,4,5-TRIFLUOROBENZENE;1,2,3-TRIFLUORO-5-BROMOBENZENE;BrC6F3H2;1-Bromo-3,4,5-trifL;5-Bromo-1,2,3-triflu;5-TrifluorobroMobenzene;3,4,5-Trifluorobromobezen;3,4,5-TrifluorobroMobezene;1-Brom-3,4,5-trifluorbenzol

CBNumber:: CB5438147

Molecular Formula:: C6H2BrF3

Molecular Weight:: 210.98

MDL Number:: MFCD00070738

MOL File:: 138526-69-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:35:56

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5-Bromo-1,2,3-trifluorobenzene Properties

Melting point	<-20°C
Boiling point	47-49 °C60 mm Hg(lit.)
Density	1.767 g/mL at 25 °C(lit.)
vapor pressure	8.65hPa at 25℃
refractive index	n20/D 1.482(lit.)
Flash point	113 °F
storage temp.	Sealed in dry,Room Temperature
solubility	0.130g/l
form	clear liquid
Specific Gravity	1.78
color	Colorless to Almost colorless
Water Solubility	insoluble
BRN	7249191
InChI	1S/C6H2BrF3/c7-3-1-4(8)6(10)5(9)2-3/h1-2H
InChIKey	HKJCELUUIFFSIN-UHFFFAOYSA-N
SMILES	Fc1cc(Br)cc(F)c1F
LogP	3.53 at 40℃
CAS DataBase Reference	138526-69-9(CAS DataBase Reference)
EWG's Food Scores	2
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS08,GHS09

Signal word

Danger

Hazard statements

H226-H315-H318-H351-H411

Precautionary statements

P210-P273-P280-P303+P361+P353-P305+P351+P338-P308+P313

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,N,Xi,F

Risk Statements

10-38-40-41-51/53-36/37/38

Safety Statements

23-26-36/37/39-61-36-16

RIDADR

UN 1993 3/PG 3

WGK Germany

Hazard Note

Irritant

HazardClass

PackingGroup

III

HS Code

29036990

Storage Class

3 - Flammable liquids

Hazard Classifications

Aquatic Chronic 2
Carc. 2
Eye Dam. 1
Flam. Liq. 3
Skin Irrit. 2

REACH Registrations

Active

Limited Quantities

5.0 L (1.3 gallons) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	2
2		0

5-Bromo-1,2,3-trifluorobenzene price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	330841	5-Bromo-1,2,3-trifluorobenzene 99%	138526-69-9	5g	$30.3	2026-04-30	Buy
TCI Chemical	B1765	1-Bromo-3,4,5-trifluorobenzene >98.0%(GC)	138526-69-9	5g	$21	2026-04-30	Buy
TCI Chemical	B1765	1-Bromo-3,4,5-trifluorobenzene >98.0%(GC)	138526-69-9	25g	$47	2026-04-30	Buy
AstaTech	CX1184	5-BROMO-1,2,3-TRIFLUOROBENZENE 98%	138526-69-9	25G	$27	2026-04-30	Buy
AstaTech	CX1184	5-BROMO-1,2,3-TRIFLUOROBENZENE 98%	138526-69-9	4*25G	$53	2026-04-30	Buy

Product number	Packaging	Price	Buy
330841	5g	$30.3	Buy
B1765	5g	$21	Buy
B1765	25g	$47	Buy
CX1184	25G	$27	Buy
CX1184	4*25G	$53	Buy

5-Bromo-1,2,3-trifluorobenzene Chemical Properties, Uses, Production

Chemical Properties

Clear slightly yellow liquid

Uses

5-Bromo-1,2,3-trifluorobenzene was used in flow preparation of 4,4,5,5-tetramethyl-2-(3,4,5-trifluorophenyl)-1,3,2-dioxaborolane.

Uses

Intermediates of Liquid Crystals

Flammability and Explosibility

Flammable

Synthesis

1489-53-8

138526-69-9

3,4,5-trifluorobromobenzene was synthesized as follows: (1) 1 mole of 1,2,3-trifluorobenzene and 3 moles of methylene chloride were added to a 2-liter reaction flask, and the mixed solution was cooled to 8-12°C; (2) 1.0 mole of sodium bromide and 120 g of sodium dihydrogen phosphate were dissolved in water to prepare an aqueous solution, which was cooled to 12°C and then added to the reaction flask of step (1); (3) at 15°C, a 10% sodium hypochlorite solution containing 1.2 moles of sodium hypochlorite was slowly added dropwise to the reaction flask, and the dropwise process lasted for 100 minutes, and then the reaction was continued at the same temperature for 60 minutes; (4) after completion of the reaction, the reaction was static layered, and the organic phase was separated, washed with water to neutrality, and dried with calcium chloride, and then the solvent was removed, and the crude 3,4,5-trifluorobromobenzene was obtained; (5) the crude product was at -25 °C Melt recrystallization was carried out to obtain 200 g of pure 3,4,5-trifluorobromobenzene with a yield of 94.6% and a purity of 99.5%.

References

[1] Patent: CN108947763, 2018, A. Location in patent: Paragraph 0020-0040
[2] European Journal of Organic Chemistry, 2003, # 3, p. 447 - 451

5-Bromo-1,2,3-trifluorobenzene synthesis

Synthesis of 5-Bromo-1,2,3-trifluorobenzene from 1,2,3-Trifluorobenzene

5-Bromo-1,2,3-trifluorobenzene Preparation Products And Raw materials

Raw materials

1,2,3-Trifluorobenzene Dichloromethane Water Sodium hypochlorite Sodium bromide

Sodium dihydrogen phosphate

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Preparation Products

3,4,5-Trifluorophenol 3,4,5-Trifluoroaniline 3',4',5'-trifluorobiphenyl-2-aMine 3,4,5-Trifluorobenzenemethanol 3',4',5'-Trifluoroacetophenone

trans-2-(3,4,5-Trifluorophenyl)cyclopentanol Benzene, 5-ethenyl-1,2,3-trifluoro- (9CI) 3,4,5-Trifluorophenylboronic acid

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5-Bromo-1,2,3-trifluorobenzene Suppliers

Global Suppliers ( 498)

Supplier	Tel	Email	Country	ProdList	Advantage
Qi-Chem Co., Ltd.	0411-88165951 13601035838	marketing@qi-chem.com	China	167	58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	13396369453 18678026865	sdfantai@163.com	China	904	58
Zhejiang Xieshi New Materials Co., Ltd.,	17858121723	sales09@xieshichem.com	China	191	58
Hangzhou Yanding Biomedical Technology Co., Ltd.	18989469219	56560759@qq.com	China	396	58
Qingdao Frisenno Biotechnology Co., Ltd	13370813718 13370813718	3073008326@qq.com	China	706	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Qi-Chem Co., Ltd.	58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	58
Zhejiang Xieshi New Materials Co., Ltd.,	58
Hangzhou Yanding Biomedical Technology Co., Ltd.	58
Qingdao Frisenno Biotechnology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81

View Latest Price from 5-Bromo-1,2,3-trifluorobenzene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	5-Bromo-1,2,3-trifluorobenzene 138526-69-9	$1.00-100.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-06-30	5-Bromo-1,2,3-trifluorobenzene 138526-69-9		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-03-20	5-Bromo-1,2,3-trifluorobenzene 138526-69-9	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

5-Bromo-1,2,3-trifluorobenzene
138526-69-9
$1.00-100.00
99%
Henan Fengda Chemical Co., Ltd

5-Bromo-1,2,3-trifluorobenzene
138526-69-9
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

5-Bromo-1,2,3-trifluorobenzene
138526-69-9
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

5-Bromo-1,2,3-trifluorobenzene Spectrum

5-Bromo-1,2,3-trifluorobenzene(138526-69-9)MS 5-Bromo-1,2,3-trifluorobenzene(138526-69-9)¹HNMR 5-Bromo-1,2,3-trifluorobenzene(138526-69-9)¹³CNMR 5-Bromo-1,2,3-trifluorobenzene(138526-69-9)IR1 5-Bromo-1,2,3-trifluorobenzene(138526-69-9)Raman

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5-BROMO-1,2,3-TRIFLUOROBENZENE 1,2,3-TRIFLUORO-5-BROMOBENZENE 1-Bromo-3,4,5-trifluoribenzene 3,4,5-Trifluoro-1-bromobenzene 3,4,5-Ttrifluorobromobenzene BENZENE, 5-BROMO-1,2,3-TRIFLUORO- 1-Bromo-3,4,5-trifluorobenzene 99% 1-Bromo-3,4,5-trifluorobenzene99% 1-Brom-3,4,5-trifluorbenzol 5-Bromo-1,2,3-triflu 3,4,5-Trifluorobromobenzene 99% 5-TrifluorobroMobenzene 3,4,5-TrifluorobroMobezene 3,4,5-Trifluorobromobezen 1-BROMO-3,4,5-TRIFLUOROBENZENE FOR SYNTH 1-Bromo-3,4,5-trifL 1-Bromo-3,4,5-trifluorobenzene for synthesis 1-romo-3,4,5-trifluorobenzene 1-Bromo-3,4,5-trifluorobenzene > 5-Bromo-1,2,3-trifluorobenzene ISO 9001：2015 REACH Tianfu Chem 5-Bromo-1,2,3-trifluorobenzene 1-Bromo-3,4,5-trifluorobenzene, 98%min 1-BROMO-3,4,5-TRIFLUOROBENZENE 3,4,5-TRIFLUOROBROMOBENZENE BrC6F3H2 138526-69-9 138526-69-6 138526-89-9 Aryl Building Blocks Organic Building Blocks Halogenated Hydrocarbons C6 Fluorine series Aryl Aryl Fluorinated Building Blocks Building Blocks Chemical Synthesis Fluorinated Building Blocks Halogenated Hydrocarbons Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks Other fluorin-contained compounds Fluorobenzene Aromatic Hydrocarbons (substituted) & Derivatives Miscellaneous Benzenes C6