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3-Methyl-4-nitropyridine N-Oxide

3-Methyl-4-nitropyridine N-Oxide structure

CAS No.: 1074-98-2

Chemical Name:: 3-Methyl-4-nitropyridine N-Oxide

Synonyms: 4-Nitro 8;3-Methyl-4-nitropyri;3-Methyl-4-nitro-1$l^{5;-4-nitropyridine N-Oxide;4-NITRO-3-PICOLINE N-OXIDE;4-Nitro-B-picoline N-oxide;4-Nitro-3-picoline 1-oxide;3-Picoline, 4-nitro-, 1-oxide;4-Nitro-beta-picoline N-oxide;4-Nitro-3-picoline-N-oxide 99%

CBNumber:: CB9205071

Molecular Formula:: C6H6N2O3

Molecular Weight:: 154.12

MDL Number:: MFCD00014626

MOL File:: 1074-98-2.mol

MSDS File:: SDS

Last updated:2026-02-05 14:54:28

Product description	Number	Pack Size	Price
3-Methyl-4-nitropyridine N-oxide 98%	370061	1g	$109
3-Methyl-4-nitropyridine N-oxide 98%	370061	5g	$379.2
3-Methyl-4-nitropyridine N-Oxide >97.0%(T)	N0527	5g	$111
3-Methyl-4-nitropyridine N-Oxide >97.0%(T)	N0527	25g	$332
3-Methyl-4-nitropyridine N-oxide	M339720	500mg	$75
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3-Methyl-4-nitropyridine N-Oxide Properties

Melting point	135-139 °C
Boiling point	277.46°C (rough estimate)
Density	1.4564 (rough estimate)
refractive index	1.5100 (estimate)
storage temp.	2-8°C
pka	-1.22±0.10(Predicted)
form	Crystalline Needles or Powder
color	Yellow
BRN	140157
Major Application	diagnostic assay manufacturing hematology histology
InChI	InChI=1S/C6H6N2O3/c1-5-4-7(9)3-2-6(5)8(10)11/h2-4H,1H3
InChIKey	SSOURMYKACOBIV-UHFFFAOYSA-N
SMILES	C1[N+]([O-])=CC=C([N+]([O-])=O)C=1C
CAS DataBase Reference	1074-98-2(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	34OB5D19MK
NIST Chemistry Reference	4-Nitro-3-picoline-n-oxide(1074-98-2)
UNSPSC Code	12171500
NACRES	NA.47

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319-H335-H351

Precautionary statements

P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xn,Xi

Risk Statements

40-20/21/22-36/37/38

Safety Statements

45-36/37-36-26-22

RIDADR

2811

WGK Germany

RTECS

UT5775000

Hazard Note

Irritant/Possible Mutagen

HazardClass

6.1

PackingGroup

HS Code

29333990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Carc. 2
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

3-Methyl-4-nitropyridine N-Oxide price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	370061	3-Methyl-4-nitropyridine N-oxide 98%	1074-98-2	1g	$109	2025-07-31	Buy
Sigma-Aldrich	370061	3-Methyl-4-nitropyridine N-oxide 98%	1074-98-2	5g	$379.2	2025-07-31	Buy
TCI Chemical	N0527	3-Methyl-4-nitropyridine N-Oxide >97.0%(T)	1074-98-2	5g	$111	2025-07-31	Buy
TCI Chemical	N0527	3-Methyl-4-nitropyridine N-Oxide >97.0%(T)	1074-98-2	25g	$332	2025-07-31	Buy
TRC	M339720	3-Methyl-4-nitropyridine N-oxide	1074-98-2	500mg	$75	2021-12-16	Buy

Product number	Packaging	Price	Buy
370061	1g	$109	Buy
370061	5g	$379.2	Buy
N0527	5g	$111	Buy
N0527	25g	$332	Buy
M339720	500mg	$75	Buy

3-Methyl-4-nitropyridine N-Oxide Chemical Properties,Uses,Production

Description

3-Methyl-4-nitropyridine N-Oxide is slightly soluble in water and soluble in common organic solvents such as ethanol. It belongs to the pyridine N-oxide class of heterocyclic compounds. It should be stored in a dry, cool, dark place away from heat sources and strong oxidants. This substance has a certain degree of toxicity, and protective measures should be taken when handling it. It is a core heterocyclic intermediate in the fields of medicine and pesticides and is mainly used to synthesize pyridine drugs and agricultural chemicals.

Chemical Properties

yellow crystalline needles or powder

Uses

diagnostic assay manufacturing
hematology
histology

General Description

3-Methyl-4-nitropyridine N-Oxide (POM) is an efficient nonlinear optical organic material having a high nonlinear coefficient and achieving the parametric emission process within the desired spectral range (1–2 μm). POM crystallizes in the orthorhombic class, space group P2₁2₁2₁, and point group 222. It is a positive biaxial crystal. It melts at 136°C and the nonlinear coefficient is deff=10 pm/V[1]. This compound exhibits a negative-linear-compressibility (NLC) region as well as exceptionally large positive thermal expansion. The initial compression of the weak supramolecular network in the molecular POM crystal is analogous to the hydrostatic responses of the framework crystals with much stronger cohesion forces. 3-Methyl-4-nitropyridine N-Oxide is a commercial NLO material for pico- and femtosecond optics in the near-IR range[2].

Synthesis

Nitration of picoline-N-oxide in the fourth position yields 3-Methyl-4-nitropyridine N-Oxide. Initially, Picoline-N-oxide (50 g) was melted at 38C and mixed with sulfuric acid (250 ml) in cold condition. Later, nitration of this mixture was done at room temperature by addition of sodium nitrate (70 g) and the solution was continuously stirred until all the solid particles dissolves. Temperature was increased slowly to 70C by keeping it in an oil bath and solution was stirred continuously for 2 h at this temperature. To ensure complete nitration, the solution was maintained about 95–100C for 12 h with continuous stirring. The reaction mixture was taken out from the oil bath and cooled. It is then poured over crushed ice and neutralized with ammonia solution till the pH reaches about 7–8. On cooling, bright yellow crystalline 3-Methyl-4-nitropyridine N-Oxide powder was obtained. It was washed and dried in vacuum[1].

References

[1] Boomadevi, S. , H. P. Mittal , and R. Dhansekaran . "Synthesis, crystal growth and characterization of 3-methyl 4-nitropyridine 1-oxide (POM) single crystals."Journal of Crystal Growth 261.1(2004):55-62.
[2] Cai, Weizhao , et al. "Anomalous compression of a weakly CHO bonded nonlinear optical molecular crystal." Journal of Materials Chemistry C 2.32(2014).

3-Methyl-4-nitropyridine N-Oxide synthesis

Synthesis of 3-Methyl-4-nitropyridine N-Oxide from 3-Picoline

3-Methyl-4-nitropyridine N-Oxide Preparation Products And Raw materials

Raw materials

3-Methyl-4-nitropyridine Dichloromethane Sulfuric acid 3-Picoline 3-Picoline-N-oxide

Nitric acid

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Preparation Products

5-Azaindole 4-Chloro-3-methylpyridine 4-Bromo-3-methylpyridine 4(1H)-Pyridinimine, 3-methyl- Acetamide, N-(3-methyl-4-pyridinyl)- (9CI)

4-methoxy-3-methylpyridine N-oxide

1of2

3-Methyl-4-nitropyridine N-Oxide Suppliers

Global( 319)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shijiazhuang Dowell Chemical Co.,Ltd	+8618633820607	sell@dowechem.com	China	89	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2950	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58

Supplier	Advantage
Shijiazhuang Dowell Chemical Co.,Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Finer Chemical Co., Ltd	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Richest Group Ltd	58
SIMAGCHEM CORP	58

View Lastest Price from 3-Methyl-4-nitropyridine N-Oxide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	4-Nitro-3-picoline N-oxide 1074-98-2	US $1.10 / g	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2025-04-04	4-Nitro-3-picoline N-oxide 1074-98-2	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2021-10-19	4-Nitro-3-picoline N-oxide 1074-98-2	US $10.00 / KG	1KG	99%	20 Tons	Hebei Zhanyao Biotechnology Co. Ltd

4-Nitro-3-picoline N-oxide
1074-98-2
US $1.10 / g
99.00%
Dideu Industries Group Limited

4-Nitro-3-picoline N-oxide
1074-98-2
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

4-Nitro-3-picoline N-oxide
1074-98-2
US $10.00 / KG
99%
Hebei Zhanyao Biotechnology Co. Ltd

3-Methyl-4-nitropyridine N-Oxide Spectrum

4-Nitro-3-picoline N-oxide(1074-98-2)MS 4-Nitro-3-picoline N-oxide(1074-98-2)¹HNMR 4-Nitro-3-picoline N-oxide(1074-98-2)¹³CNMR 4-Nitro-3-picoline N-oxide(1074-98-2)IR1 4-Nitro-3-picoline N-oxide(1074-98-2)IR2

1074-98-2(3-Methyl-4-nitropyridine N-Oxide)Related Search:

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2-Chloro-5-chloromethylpyridine 4-Nitropyridine Methyl acetate 2-Methyl-4-nitropyridine 4-Methylpyridine

3-Picoline Pirimiphos-methyl METSULFURON METHYL 2,6-Lutidine 2,4,6-Collidine

Methyl salicylate Thiophanate-methyl Methyl

1of4

3-METHYL-4-NITROPYRIDINE N-OXIDE 98% 4-Nitro-3-picoline-N-oxide 99% 3-methyl-4-nitro-1-oxidopyridin-1-ium 3-Methyl-4-nitro-1$l^{5 3-METHYL-4-NITROPYRIDINE N-OXIDE4-Nitro-3-picoline-N-oxide 4-NITRO-3-PICOLINE N-OXIDE 3-METHYL-4-NITROPYRIDINE 1-OXIDE 3-METHYL-4-NITROPYRIDINE N-OXIDE 4-Nitro-B-picoline N-oxide 3-Methyl-4-nitropyridine N-oxide,98% 3-Methyl-4-nitropyri 3-Methyl-4-nitropyridine N-oxide ,97% 3-Methyl-4-nitro-1$l^{5}-pyridin-1-one 3-Methyl-4-nitropyridine N-oxide, 98% 1GR 3-Methyl-4-nitro-pyridin1-o×ide 4-Nitro-3-picoline N-oxide, 3-Methyl-4-nitropyridinium-1-olate 3-methyl-4-nitro-pyridin1-oxide 3-Picoline, 4-nitro-, 1-oxide 4-Nitro-3-methylpyridine N-oxide 4-Nitro-3-picoline 1-oxide 4-Nitro-beta-picoline N-oxide 5-Methyl-4-nitropyridine N-oxide Pyridine, 3-methyl-4-nitro-, 1-oxide 3-Methyl-4-nitropyridine N-Oxide 3-Methyl-4-nitropyridin-1-oxid 3-Methyl-4-nitropyridineN-Oxide> -4-nitropyridine N-Oxide 4-Nitro-3-picoline N-oxide ISO 9001：2015 REACH Pyridine, 3-methyl-4-nitro-, 1-oxide (9CI, ACI) 3-methyl-4-nitro-Pyridine 1-oxide (9CI ACI) 3-Methyl-4-nitropyridine oxide 4-Nitro 8 1074-98-2 1047-98-0 1074-98-0 Organic Nonlinear Optical Materials CHIRAL CHEMICALS NLO Chromophores and Intermediates Non-Linear Optical (NLO) Materials Photonic and Optical Materials Pyridines Functional Materials Organic Nonlinear Optical Materials Pyridine