3-Methyl-4-nitropyridine N-Oxide
- CAS No.
- 1074-98-2
- Chemical Name:
- 3-Methyl-4-nitropyridine N-Oxide
- Synonyms
- 3-METHYL-4-NITROPYRIDINE 1-OXIDE;4-Nitro 8;3-Methyl-4-nitropyri;3-Methyl-4-nitro-1$l^{5;-4-nitropyridine N-Oxide;4-NITRO-3-PICOLINE N-OXIDE;4-Nitro-B-picoline N-oxide;4-Nitro-3-picoline 1-oxide;3-Picoline, 4-nitro-, 1-oxide;4-Nitro-beta-picoline N-oxide
- CBNumber:
- CB9205071
- Molecular Formula:
- C6H6N2O3
- Molecular Weight:
- 154.12
- MDL Number:
- MFCD00014626
- MOL File:
- 1074-98-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 135-139 °C |
|---|---|
| Boiling point | 277.46°C (rough estimate) |
| Density | 1.4564 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | 2-8°C |
| pka | -1.22±0.10(Predicted) |
| form | Crystalline Needles or Powder |
| color | Yellow |
| BRN | 140157 |
| Major Application |
diagnostic assay manufacturing hematology histology |
| InChI | InChI=1S/C6H6N2O3/c1-5-4-7(9)3-2-6(5)8(10)11/h2-4H,1H3 |
| InChIKey | SSOURMYKACOBIV-UHFFFAOYSA-N |
| SMILES | C1[N+]([O-])=CC=C([N+]([O-])=O)C=1C |
| CAS DataBase Reference | 1074-98-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 34OB5D19MK |
| NIST Chemistry Reference | 4-Nitro-3-picoline-n-oxide(1074-98-2) |
| UNSPSC Code | 12171500 |
| NACRES | NA.47 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335-H351 | |||||||||
| Precautionary statements | P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 40-20/21/22-36/37/38 | |||||||||
| Safety Statements | 45-36/37-36-26-22 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UT5775000 | |||||||||
| Hazard Note | Irritant/Possible Mutagen | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Carc. 2 Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Methyl-4-nitropyridine N-Oxide price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 370061 | 3-Methyl-4-nitropyridine N-oxide 98% | 1074-98-2 | 1g | $114 | 2026-04-30 | Buy |
| Sigma-Aldrich | 370061 | 3-Methyl-4-nitropyridine N-oxide 98% | 1074-98-2 | 5g | $291.9 | 2026-04-30 | Buy |
| TCI Chemical | N0527 | 3-Methyl-4-nitropyridine N-Oxide >97.0%(T) | 1074-98-2 | 5g | $94 | 2026-04-30 | Buy |
| TCI Chemical | N0527 | 3-Methyl-4-nitropyridine N-Oxide >97.0%(T) | 1074-98-2 | 25g | $282 | 2026-04-30 | Buy |
| AstaTech | 63194 | 3-METHYL-4-NITRO-PYRIDINE 1-OXIDE 97% | 1074-98-2 | 25G | $56 | 2026-04-30 | Buy |
3-Methyl-4-nitropyridine N-Oxide Chemical Properties, Uses, Production
Description
3-Methyl-4-nitropyridine N-Oxide is slightly soluble in water and soluble in common organic solvents such as ethanol. It belongs to the pyridine N-oxide class of heterocyclic compounds. It should be stored in a dry, cool, dark place away from heat sources and strong oxidants. This substance has a certain degree of toxicity, and protective measures should be taken when handling it. It is a core heterocyclic intermediate in the fields of medicine and pesticides and is mainly used to synthesize pyridine drugs and agricultural chemicals.
Chemical Properties
yellow crystalline needles or powder
Uses
diagnostic assay manufacturing
hematology
histology
General Description
3-Methyl-4-nitropyridine N-Oxide (POM) is an efficient nonlinear optical organic material having a high nonlinear coefficient and achieving the parametric emission process within the desired spectral range (1–2 μm). POM crystallizes in the orthorhombic class, space group P212121, and point group 222. It is a positive biaxial crystal. It melts at 136°C and the nonlinear coefficient is deff=10 pm/V[1]. This compound exhibits a negative-linear-compressibility (NLC) region as well as exceptionally large positive thermal expansion. The initial compression of the weak supramolecular network in the molecular POM crystal is analogous to the hydrostatic responses of the framework crystals with much stronger cohesion forces. 3-Methyl-4-nitropyridine N-Oxide is a commercial NLO material for pico- and femtosecond optics in the near-IR range[2].
Synthesis
Nitration of picoline-N-oxide in the fourth position yields 3-Methyl-4-nitropyridine N-Oxide. Initially, Picoline-N-oxide (50 g) was melted at 38C and mixed with sulfuric acid (250 ml) in cold condition. Later, nitration of this mixture was done at room temperature by addition of sodium nitrate (70 g) and the solution was continuously stirred until all the solid particles dissolves. Temperature was increased slowly to 70C by keeping it in an oil bath and solution was stirred continuously for 2 h at this temperature. To ensure complete nitration, the solution was maintained about 95–100C for 12 h with continuous stirring. The reaction mixture was taken out from the oil bath and cooled. It is then poured over crushed ice and neutralized with ammonia solution till the pH reaches about 7–8. On cooling, bright yellow crystalline 3-Methyl-4-nitropyridine N-Oxide powder was obtained. It was washed and dried in vacuum[1].
References
[1] Boomadevi, S. , H. P. Mittal , and R. Dhansekaran . "Synthesis, crystal growth and characterization of 3-methyl 4-nitropyridine 1-oxide (POM) single crystals."Journal of Crystal Growth 261.1(2004):55-62.
[2] Cai, Weizhao , et al. "Anomalous compression of a weakly CHO bonded nonlinear optical molecular crystal." Journal of Materials Chemistry C 2.32(2014).
3-Methyl-4-nitropyridine N-Oxide Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangyin Jufeng Biotechnology Co., Ltd | 0519-89891966 13906113265 | 986329407@qq.com | China | 55 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing dtftchem Technology Co., Ltd. | 010-60275820 13031183356 | elainezt@sina.com | China | 1386 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from 3-Methyl-4-nitropyridine N-Oxide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 4-Nitro-3-picoline N-oxide
1074-98-2
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-06-30 | 3-Methyl-4-nitropyridine N-Oxide
1074-98-2
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | 4-Nitro-3-picoline N-oxide
1074-98-2
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 4-Nitro-3-picoline N-oxide
1074-98-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 3-Methyl-4-nitropyridine N-Oxide
1074-98-2
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-Nitro-3-picoline N-oxide
1074-98-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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