2-Fluoro-5-nitroaniline
- CAS No.
- 369-36-8
- Chemical Name:
- 2-Fluoro-5-nitroaniline
- Synonyms
- 2-Fluoro-5-nitrobenzenamine;uoro-5-nitroaniL;Fluoronitroaniline1;2-Fluoro-5-nitroanil;5-Nitro-2-fluoroaniline;2-FLUORO-5-NITROANILINE;6-fluoro-3-nitroaniline;Aniline, 2-fluoro-5-nitro-;2-Fluoro-5-nitroaniline98%;2-Fluoro-5-nitroaniline>
- CBNumber:
- CB9226014
- Molecular Formula:
- C6H5FN2O2
- Molecular Weight:
- 156.11
- MDL Number:
- MFCD00007652
- MOL File:
- 369-36-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 97-100 °C (lit.) |
|---|---|
| Boiling point | 295.5±20.0 °C(Predicted) |
| Density | 1.3822 (estimate) |
| Flash point | 196 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Crystalline Powder |
| pka | 1.13±0.10(Predicted) |
| color | Ochre-yellow to light brown |
| Water Solubility | Slightly soluble |
| BRN | 2803491 |
| InChI | InChI=1S/C6H5FN2O2/c7-5-2-1-4(9(10)11)3-6(5)8/h1-3H,8H2 |
| InChIKey | KJVBJICWGQIMOZ-UHFFFAOYSA-N |
| SMILES | C1(N)=CC([N+]([O-])=O)=CC=C1F |
| CAS DataBase Reference | 369-36-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Fluoro-5-nitroaniline(369-36-8) |
| EPA Substance Registry System | Benzenamine, 2-fluoro-5-nitro- (369-36-8) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H228-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | F,Xi | |||||||||
| Risk Statements | 11-36/37/38 | |||||||||
| Safety Statements | 16-26-36 | |||||||||
| RIDADR | UN 1325 4.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214210 | |||||||||
| Storage Class | 4.1B - Flammable solid hazardous materials | |||||||||
| Hazard Classifications | Eye Irrit. 2 Flam. Sol. 1 Skin Irrit. 2 STOT SE 3 |
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| Limited Quantities | 1.0 Kg (2.2 lbs) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
2-Fluoro-5-nitroaniline price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 155853 | 2-Fluoro-5-nitroaniline 98% | 369-36-8 | 25g | $89.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | 155853 | 2-Fluoro-5-nitroaniline 98% | 369-36-8 | 100g | $281 | 2023-06-20 | Buy |
| TCI Chemical | F0267 | 2-Fluoro-5-nitroaniline >99.0%(GC) | 369-36-8 | 25g | $65 | 2026-04-30 | Buy |
| Usbiological | 276011 | 2-Fluoro-5-nitroaniline Asreported | 369-36-8 | 50g | $382 | 2026-06-03 | Buy |
| Usbiological | 276011 | 2-Fluoro-5-nitroaniline Asreported | 369-36-8 | 100g | $542 | 2026-06-03 | Buy |
2-Fluoro-5-nitroaniline Chemical Properties, Uses, Production
Chemical Properties
ochre-yellow to light brown crystalline powder
Uses
It is employed as pharmaceutical intermediate.
Synthesis Reference(s)
Tetrahedron Letters, 31, p. 6141, 1990 DOI: 10.1016/S0040-4039(00)97008-4
Synthesis
70-34-8
369-36-8
The general procedure for the synthesis of 2-fluoro-5-nitroaniline from 2,4-dinitrofluorobenzene is as follows: 18.61 g (0.10 mol) of 2,4-dinitrofluorobenzene, 0.5 g of 5% palladium-carbon catalyst, 100 mL of glacial acetic acid, and 100 mL of anhydrous ethanol were added to a 500 mL Parr hydrogenation unit. The device was equipped with a thermocouple and a cooling jacket. During the reaction, the temperature of the reaction mixture was maintained at 20-25°C, the hydrogen pressure was maintained at 370 psi, and the reaction time was 2.5 hours. Upon completion of the reaction, the reaction mixture was poured into 400 mL of water. It was extracted twice with 200 mL of dichloromethane, the organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the resulting residue was filtered through a silica gel pad and eluted with dichloromethane. The eluate was concentrated again under reduced pressure and the residue was further purified by column chromatography using dichloromethane:heptane (80:20, v/v) as eluent. Finally, the solvent was evaporated under reduced pressure to give 2.75 g of 2-fluoro-5-nitroaniline in 17.6% yield.
References
[1] Patent: US5105012, 1992, A
[2] Recueil des Travaux Chimiques des Pays-Bas, 1916, vol. 35, p. 142
[3] Chem. Zentralbl., 1913, vol. 84, # II, p. 760
2-Fluoro-5-nitroaniline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Anchor Biological Technology Co., Ltd | 0519-85519868 18915088878 | sales@ankerbio.com | China | 260 | 58 |
| Changzhou Xinda Biotechnology Co., Ltd | 0519-85519868 18915088878 | xiaoweng106108@163.com | China | 99 | 58 |
| Hangzhou Copiore Chemical Co., Ltd. | 17300981287 13757145729 | sales@copiore.com | China | 291 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Liaoning Tianhua Chemical Co., Ltd. | 0418-6530555 2855550 | China | 338 | 69 | |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
View Latest Price from 2-Fluoro-5-nitroaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-Fluoro-5-nitroaniline
369-36-8
|
$8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-07 | 2-Fluoro-5-nitroaniline
369-36-8
|
$1.00-4.00 | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2026-06-30 | 2-Fluoro-5-nitroaniline
369-36-8
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2-Fluoro-5-nitroaniline
369-36-8
- $8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Fluoro-5-nitroaniline
369-36-8
- $1.00-4.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Fluoro-5-nitroaniline
369-36-8
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
