4-Hydroxybenzophenone
- CAS No.
- 1137-42-4
- Chemical Name:
- 4-Hydroxybenzophenone
- Synonyms
- POB;P-HYDROXYBENZOPHENONE;(4-hydroxyphenyl)phenyl-methanon;4-Hydroxydiphenylketone;4',2,4-trimethoxy benzophenone;NSC 1887;ENCL-001;benzoylphenol;Ospemifene INT;P-BENZOYLPHENOL
- CBNumber:
- CB9237221
- Molecular Formula:
- C13H10O2
- Molecular Weight:
- 198.22
- MDL Number:
- MFCD00002355
- MOL File:
- 1137-42-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 132-135 °C(lit.) |
|---|---|
| Boiling point | 260-262°C 42mm |
| Density | 1.1184 (rough estimate) |
| vapor pressure | 0Pa at 20℃ |
| refractive index | 1.5954 (estimate) |
| Flash point | 260-262°C/24mm |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Powder |
| pka | 8.14±0.13(Predicted) |
| color | White to beige to brown |
| Water Solubility | Insoluble in water. |
| BRN | 777776 |
| InChI | 1S/C13H10O2/c14-12-8-6-11(7-9-12)13(15)10-4-2-1-3-5-10/h1-9,14H |
| InChIKey | NPFYZDNDJHZQKY-UHFFFAOYSA-N |
| SMILES | Oc1ccc(cc1)C(=O)c2ccccc2 |
| LogP | 1.6 at 35℃ |
| CAS DataBase Reference | 1137-42-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 04R2LWS0MS |
| NIST Chemistry Reference | Methanone, (4-hydroxyphenyl)phenyl-(1137-42-4) |
| EPA Substance Registry System | Methanone, (4-hydroxyphenyl)phenyl- (1137-42-4) |
| UNSPSC Code | 12352115 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H373-H412 | |||||||||
| Precautionary statements | P260-P273-P314-P501 | |||||||||
| target organs | Liver,Kidney | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37-24/25-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | PC4959775 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29145000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Aquatic Chronic 3 STOT RE 2 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
4-Hydroxybenzophenone price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H20202 | 4-Hydroxybenzophenone 98% | 1137-42-4 | 25g | $74.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | H20202 | 4-Hydroxybenzophenone 98% | 1137-42-4 | 100g | $253 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.20661 | 4-Hydroxybenzophenone for synthesis | 1137-42-4 | 25g | $55.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.20661 | 4-Hydroxybenzophenone for synthesis | 1137-42-4 | 100g | $186 | 2026-04-30 | Buy |
| TCI Chemical | H0222 | 4-Hydroxybenzophenone >98.0%(GC)(T) | 1137-42-4 | 25g | $45 | 2026-04-30 | Buy |
4-Hydroxybenzophenone Chemical Properties, Uses, Production
Chemical Properties
white to beige fine crystalline powder
Uses
Metabolite of benzophenone.
Uses
4-Hydroxybenzophenone is used in the field of organic synthesis. It is used as pharmaceutical intermediate of clomifene citrate.
Definition
ChEBI: 4-Hydroxybenzophenone is a member of benzophenones.
Preparation
Preparation by condensation of benzotrichloride,
with phenol in the presence of aluminium chloride in carbon disulfide at 0° (90%) or in the presence of zinc oxide in a water bath;
with p-bromophenol in 30% sodium hydroxide solution at 80–85° (81%). There is substitution of the bromine atom by the benzoyl group.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 4674, 1955 DOI: 10.1021/ja01622a074
The Journal of Organic Chemistry, 19, p. 978, 1954 DOI: 10.1021/jo01371a016
Tetrahedron Letters, 31, p. 3943, 1990 DOI: 10.1016/S0040-4039(00)97513-0
Flammability and Explosibility
Not classified
Purification Methods
Dissolve p-benzoylphenol in hot EtOH (charcoal), filter and cool. Alternatively crystallise it once from EtOH/H2O and twice from *benzene [Grunwald J Am Chem Soc 73 4934 1951, Dryland & Sheppard J Chem Soc Perkin Trans 1 125 1986]. [Beilstein 8 IV 1263.]
4-Hydroxybenzophenone Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. | 13396369453 18678026865 | sdfantai@163.com | China | 904 | 58 |
| Changzhou Luowan Biological Technology Co., Ltd. | 13646143635;18069669245 | 617837247@qq.com | China | 142 | 58 |
| SINO HIGH(CHINA)CO.,LTD. | 15295090350 13914336446 | chang@sinohighchem.com | China | 40 | 58 |
| Shandong Xibang Biological Technology Development Co. LTD | 0536-3611186 15063661551 | 196056703@qq.com | China | 59 | 58 |
| Wuhan EnTai Technology Development Co,.Ltd | 86-27-82330560 | 2536851935@qq.com | China | 346 | 69 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
View Latest Price from 4-Hydroxybenzophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-10-21 | 4-Hydroxybenzophenone
1137-42-4
|
$66.00-99.00 | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | ||
 |
2026-08-20 | 4-Hydroxybenzophenone
1137-42-4
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-07-15 | 4-Hydroxybenzophenone
1137-42-4
|
99.84% | 10g | TargetMol Chemicals Inc. |
-
- 4-Hydroxybenzophenone
1137-42-4
- $66.00-99.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- 4-Hydroxybenzophenone
1137-42-4
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- 4-Hydroxybenzophenone
1137-42-4
- $0.00
- 99.84%
- TargetMol Chemicals Inc.
