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ORITAVANCIN

ORITAVANCIN structure

CAS No.: 171099-57-3

Chemical Name:: ORITAVANCIN

Synonyms: CS-2274;Orbactiv;LY 333328;ORITAVANCIN;Ollivan Star;brand name: Orbactiv;Oritavancin (LY333328);Oritavancin, trifluoacetate salt;13C6]-Oritavancin, trifluoacetate salt;Oritavancin (Lyophilized Powder For IV Infusion)

CBNumber:: CB92451283

Molecular Formula:: C86H97Cl3N10O26

Molecular Weight:: 1793.1

MDL Number:: MFCD12756396

MOL File:: 171099-57-3.mol

MSDS File:: SDS

Last updated:2025-05-29 21:57:13

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ORITAVANCIN Properties

Density	1.59±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	2.93±0.70(Predicted)
FDA UNII	PUG62FRZ2E
ATC code	J01XA05

Pharmacokinetic data

Protein binding	85%
Excreted unchanged in urine	<1%
Volume of distribution	87.6 Litres
Biological half-life	245 / Unchanged

ORITAVANCIN price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	API0008111	ORITAVANCIN 95.00%	171099-57-3	5MG	$496.02	2021-12-16	Buy

Product number	Packaging	Price	Buy
API0008111	5MG	$496.02	Buy

ORITAVANCIN Chemical Properties,Uses,Production

Definition

ChEBI: A semisynthetic glycopeptide used (as its bisphosphate salt) for the treatment of acute bacterial skin and skin structure infections caused or suspected to be caused by susceptible isolates of designated Gram-positive microorganisms including MRSA.

Clinical Use

Antibacterial agent

Enzyme inhibitor

This novel, semi-synthetic glycopeptide antibiotic (FW = 1793.10 g/mol; CAS 171099-57-3), also known as LY333328, Orbactiv?, and (4R)-22-O- (3-amino-2,3,6-trideoxy-3-C-methyl-a-L-arabinohexopyranosyl)-N3-(p-(pchlorophenyl) benzyl)vancomycin, disrupts the cell membrane of Grampositive bacteria and inhibits both transglycosylation and transpeptidation. Oritavancin differs from vancomycin by the presence of a hydrophobic N-4-(4-chlorophenyl)benzyl substituent on the disaccharide, the addition of a 4-epi-vancosamine monosaccharide to the amino acid residue in Ring-6, and replacement of the vancosamine moiety by 4-epi-vancosamine. When compared vancomycin, teicoplanin, and quinupristin-dalfopristin (Synercid) against 219 strains of enterococci and staphylococci, including vancomycin-resistant enterococci and methicillinresistant methicillinresistant Staphylococcus aureus, LY333328 demonstrated superior activity against vancomycin-resistant enterococci and was the only antibiotic which was bactericidal. Indeed, a single infusion of this antibiotic (1200 mg) can clear serious bacterial skin infections, including methicillin-resistant Staphylococcus aureus, or MRSA, as effectively as the usual 7-10 day, twice-daily regimen of vancomycin now needed to treat patients.

Drug interactions

Potentially hazardous interactions with other drugs
Anticoagulants: possibly increases warfarin concentration.

Metabolism

In vitro human liver microsome studies indicated that oritavancin is not metabolised. It is excreted unchanged; less than 1% and 5% of a dose is recovered in the urine and the faeces.

ORITAVANCIN Preparation Products And Raw materials

Raw materials

Preparation Products

ORITAVANCIN Suppliers

Global( 100)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	997	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Wuhan JiyunZen Tech Co., Ltd.	+86-18062099985	Amyjiyunzen@yeah.net	China	663	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Shanghai Worldyang Chemical Co.,Ltd.	+86-021-56795779 +8613651600618	sales@worldyachem.com	China	1382	58
Longyan Tianhua Biological Technology Co., Ltd	0086 18039857276 18039857276		CHINA	2783	58
Qiuxian Baitai New Material Co., LTD	+8618330912755	sale2@hbyalin.com	China	1658	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58

Supplier	Advantage
Shaanxi Haibo Biotechnology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Wuhan JiyunZen Tech Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shanghai Worldyang Chemical Co.,Ltd.	58
Longyan Tianhua Biological Technology Co., Ltd	58
Qiuxian Baitai New Material Co., LTD	58
ANHUI WITOP BIOTECH CO., LTD	58

What is Oritavancin?
Oritavancin is a second-generation lipoglycopeptide antibiotic derived from modifications of chloroeremomycin, a naturally occ....
Mar 10，2022

View Lastest Price from ORITAVANCIN manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-08-12	ORITAVANCIN 171099-57-3			0.99		RongNa Biotechnology Co.,Ltd
2025-08-05	ORITAVANCIN 171099-57-3	US $5.00-0.50 / KG	1KG	99% hplc	500TONS	Wuhan JiyunZen Tech Co., Ltd.
2025-07-21	Oritavancin(LY-333328) 171099-57-3	US $192.00-339.00 / mg			10g	TargetMol Chemicals Inc.

ORITAVANCIN
171099-57-3
0.99
RongNa Biotechnology Co.,Ltd

ORITAVANCIN
171099-57-3
US $5.00-0.50 / KG
99% hplc
Wuhan JiyunZen Tech Co., Ltd.

Oritavancin(LY-333328)
171099-57-3
US $192.00-339.00 / mg
TargetMol Chemicals Inc.

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ORITAVANCIN Oritavancin (LY333328) (4R)-22-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-a-L-arabinohexopyranosyl)-N3-(p-(p-chlorophenyl)benzyl)vancomycin (4''R)-22-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-N3''-[(4'-chloro[1,1'-biphenyl]-4-yl)methyl]vancomycin LY 333328 Orbactiv Oritavancin (Lyophilized Powder For IV Infusion) rideoxy-3-methyl-α-L-arabino-hexopyranosyl)-β-D-g CS-2274 brand name: Orbactiv LY333328; LY-333328; LY 333328; ORITAVANCIN; BRAND NAME: ORBACTIV Vancomycin, 22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-arabino-hexopyranosyl)-N3''-[(4'-chloro[1,1'-biphenyl]-4-yl)methyl]-, (4''R)- Oritavancin, trifluoacetate salt Vancomycin,22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-a-L-arabino-hexopyranosyl)-N3''-[(4'-chloro[1,1'-biphenyl]-4-yl)methyl]-,(4''R)- 13C6]-Oritavancin, trifluoacetate salt Ollivan Star Vancomycin, 22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-arabino-hexopyranosyl)-N3′′-[(4′-chloro[1,1′-biphenyl]-4-yl)methyl]-, (4′′R)- 171099-57-3 C86H97Cl3N10O26