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N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-3-[(Z)-[(5Z)-4-methyl-3,6-dioxo-5-(phenylmethylene)piperazinylidene]methyl]benzamidehydrochloride

N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-3-[(Z)-[(5Z)-4-methyl-3,6-dioxo-5-(phenylmethylene)piperazinylidene]methyl]benzamidehydrochloride Structure
N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-3-[(Z)-[(5Z)-4-methyl-3,6-dioxo-5-(phenylmethylene)piperazinylidene]methyl]benzamidehydrochloride structure
CAS No.
180422-22-4
Chemical Name:
N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-3-[(Z)-[(5Z)-4-methyl-3,6-dioxo-5-(phenylmethylene)piperazinylidene]methyl]benzamidehydrochloride
Synonyms
XR 9051 HCl;XR9051 (hydrochloride);XR9051 Hydrochloride,XR-9051 Hydrochloride;3-[(Z)-[(5Z)-5-benzylidene-4-methyl-3,6-dioxopiperazin-2-ylidene]methyl]-N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]benzamide:hydrochloride;N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-3-[(Z)-[(5Z)-4-methyl-3,6-dioxo-5-(phenylmethylene)piperazinylidene]methyl]benzamidehydrochloride
CBNumber:
CB92518830
Molecular Formula:
C39H39ClN4O5
Molecular Weight:
679.21
MDL Number:
MFCD00952136
MOL File:
180422-22-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:36:07
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N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-3-[(Z)-[(5Z)-4-methyl-3,6-dioxo-5-(phenylmethylene)piperazinylidene]methyl]benzamidehydrochloride Properties

storage temp. Store at -20°C

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P305+P351+P338

N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-3-[(Z)-[(5Z)-4-methyl-3,6-dioxo-5-(phenylmethylene)piperazinylidene]methyl]benzamidehydrochloride price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0009971 XR 9051 HYDROCHLORIDE 95.00% 180422-22-4 1KG $13744.5 2021-12-16 Buy
Product number Packaging Price Buy
API0009971 1KG $13744.5 Buy

N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-3-[(Z)-[(5Z)-4-methyl-3,6-dioxo-5-(phenylmethylene)piperazinylidene]methyl]benzamidehydrochloride Chemical Properties, Uses, Production

Uses

XR9051 hydrochloride is an orally active and specific modulator of P-glycoprotein-mediated multidrug resistance (MDR)[1].

in vivo

XR9051 (20-40 mg/kg, ip) shows significant modulatory activity in mice bearing MDR human ovarian (2780AD and CH1/DOXr) and SCLC (H69/LX) xenografts[2].

Animal Model:Female Balb/c mice (20-25 g)[2].
Dosage:I.V.
Administration:20 mg/kg at various times (5 min to 24 h).
Result:The area under the concentration time curves (AUC) from time 0-∞ for plasma was 11.9 μg. h mL-1. The ratio between AUC for tissue:plasma for liver, heart and brain were 79.6, 16.9 and 0.3 respectively.
Animal Model:MDR 2780AD ovarian carcinoma xenografts[2].
Dosage:I.P.
Administration:20, 30, 40 mg/kg daily with Epirubicin i.v. (10 mg/kg).
Result:Significantly reduced growth rate of MDR 2780AD ovarian carcinoma xenografts compared with either drug alone.

References

[1] I L Dale , et al. Reversal of P-glycoprotein-mediated multidrug resistance by XR9051, a novel diketopiperazine derivative. Br J Cancer. 1998 Oct;78(7):885-92. DOI:10.1038/bjc.1998.597
[2] P Mistry, et al. In vivo efficacy of XR9051, a potent modulator of P-glycoprotein mediated multidrug resistance. Br J Cancer. 1999 Apr;79(11-12):1672-8. DOI:10.1038/sj.bjc.6690267

N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-3-[(Z)-[(5Z)-4-methyl-3,6-dioxo-5-(phenylmethylene)piperazinylidene]methyl]benzamidehydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-3-[(Z)-[(5Z)-4-methyl-3,6-dioxo-5-(phenylmethylene)piperazinylidene]methyl]benzamidehydrochloride Suppliers

Global Suppliers ( 9)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
DAYANG CHEM (HANGZHOU) CO.,LTD +86-88938639 +86-17705817739 info@dycnchem.com China 53589 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
TargetMol Chemicals Inc. +1-781-999-5354; support@targetmol.com United States 38999 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
EMMX Biotechnology LLC 60
TargetMol Chemicals Inc. 58
DAYANG CHEM (HANGZHOU) CO.,LTD 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-3-[(Z)-[(5Z)-4-methyl-3,6-dioxo-5-(phenylmethylene)piperazinylidene]methyl]benzamidehydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
XR9051 Hydrochloride pictures 2026-04-21 XR9051 Hydrochloride
180422-22-4
 $1820.00-3100.00 10g TargetMol Chemicals Inc.

180422-22-4 (N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-3-[(Z)-[(5Z)-4-methyl-3,6-dioxo-5-(phenylmethylene)piperazinylidene]methyl]benzamidehydrochloride) Related Search:

Atazanavir Solamargine (2R)-1-{4-[(1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol Piperine Trifluoperazine dihydrochloride
Bifendate

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N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-3-[(Z)-[(5Z)-4-methyl-3,6-dioxo-5-(phenylmethylene)piperazinylidene]methyl]benzamidehydrochloride XR 9051 HCl XR9051 (hydrochloride) 3-[(Z)-[(5Z)-5-benzylidene-4-methyl-3,6-dioxopiperazin-2-ylidene]methyl]-N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]benzamide:hydrochloride XR9051 Hydrochloride,XR-9051 Hydrochloride 180422-22-4 C39H36N4O5HCl