trans-CloMiphene Hydrochloride
- CAS No.
- 14158-65-7
- Chemical Name:
- trans-CloMiphene Hydrochloride
- Synonyms
- Enclomiphene HCl;EncloMifene Hydrochlor;trans-Clomiphene-d5 HCl;Enclomiphene hydrochloride;(E)-CloMiphene Hydrochloide;(E)-Clomiphene hydrochloride;trans-Clomifene hydrochloride;rans-CloMiphene Hydrochloride;D4-Enclomiphene Hydrochloride;trans-CloMiphene Hydrochloride
- CBNumber:
- CB92544149
- Molecular Formula:
- C26H29Cl2NO
- Molecular Weight:
- 442.42056
- MDL Number:
- MFCD08060098
- MOL File:
- 14158-65-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 156.6-158 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: soluble10mg/mL, clear |
| form | powder |
| color | white to beige |
| Water Solubility | H2O: 10mg/mL, clear |
| Stability | Light Sensitive |
| InChI | InChI=1S/C26H28ClNO.ClH/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23;/h5-18H,3-4,19-20H2,1-2H3;1H/b26-25+; |
| InChIKey | KKBZGZWPJGOGJF-BTKVJIOYSA-N |
| SMILES | c1c(/C(/c2ccccc2)=C(/Cl)\c2ccccc2)ccc(OCCN(CC)CC)c1.Cl |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
trans-CloMiphene Hydrochloride price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0719 | Enclomiphene hydrochloride ≥96% (HPLC) | 14158-65-7 | 5mg | $84 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML0719 | Enclomiphene hydrochloride ≥96% (HPLC) | 14158-65-7 | 25mg | $469 | 2025-07-31 | Buy |
| TRC | TRC-C587035-5MG | trans-Clomiphene Hydrochloride >95%(HPLC) | 14158-65-7 | 5mg | $138 | 2026-06-03 | Buy |
| TRC | TRC-C587035-25MG | trans-Clomiphene Hydrochloride >95%(HPLC) | 14158-65-7 | 25mg | $485 | 2026-06-03 | Buy |
| TRC | TRC-C587035-2.5MG | trans-Clomiphene Hydrochloride >95%(HPLC) | 14158-65-7 | 2.5mg | $117 | 2026-06-03 | Buy |
trans-CloMiphene Hydrochloride Chemical Properties, Uses, Production
Uses
Trans isomer of Clomiphene (C587025). Found to be slightly estrogenic and a less potent inhibitor of LH secretion than the cis isomer.
Uses
Trans isomer of Clomiphene (C587025). Found to be slightly estrogenic and a more potent inhibitor of LH secretion than the cis isomer.
Biological Activity
Enclomiphene is a non-steroidal estrogen receptor antagonist th at promotes gonadotropin-dependent testosterone secretion by the testes. Enclomiphene is the trans-isomer of clomiphene, which is about a 60-40 mix of trans (Enclomiphene) and cis (Zuclomiphene). While enclomiphene (trans-clomiphene) is an estrogen antagonist, zuclomiphene (cis-clomiphene) is a mixed agonist, responsible for the estrogenic activity and therefore the common side effects sometimes seen in males. The enclomiphene isomer is responsible for the anti-estrogen activity and the restoration of ones hypothalamic–pituitary–gonadal axis. In recent clinical trials, enclomiphene increased serum LH and FSH with concomitant increases in testosterone in men with secondary hypogonadism. Enclomiphene showed overall better results than testosterone gels, which raise serum testosterone but can lower LH and FSH at the same time.
in vivo
Enclomiphene hydrochloride (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats[5].
Enclomiphene hydrochloride (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol[6].
| Animal Model: | 21 days-old Charles River male rats[5] |
| Dosage: | 0.25 and 0.5 mg/animal, daily for 24 days. |
| Administration: | Subcutaneous injection |
| Result: | Decreased LH and testosterone levels in the serum. |
| Animal Model: | OVX (ovariectomy) rat model[6] |
| Dosage: | 0.03, 1, and 3 mg/kg, daily for 90 days. |
| Administration: | Oral adminstration |
| Result: | Reducted body weight to sham levels, and reduced serum cholesterol. Showed dose-dependent effects on the proximal tibia with BMD and BMC approaching posttreatment Sham levels. |
trans-CloMiphene Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Yinuokai New Materials Co., Ltd | 15764055027 15764055027 | 15764055027@163.com | China | 539 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 7982 | 55 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9609 | 60 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 17754423994 | candy@biochempartner.com | China | 3057 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Shanghai UCHEM Inc. | +86-18930848214 +86-021-56762820 | sales@myuchem.com | China | 8966 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
View Latest Price from trans-CloMiphene Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-26 | Enclomiphene
14158-65-7
|
$38.00 | 1BOX | 99.9 | 9999 | Rongchuang International | |
 |
2026-08-25 | Enclomiphene hydrochloride
14158-65-7
|
100g | 99% | 50kg | Xi an Biohorlden Industry Trade Co Ltd |
-
- Enclomiphene
14158-65-7
- $38.00
- 99.9
- Rongchuang International
-
- Enclomiphene hydrochloride
14158-65-7
- 99%
- Xi an Biohorlden Industry Trade Co Ltd
