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Nortadalafil

Nortadalafil structure

CAS No.: 171596-36-4

Chemical Name:: Nortadalafil

Synonyms: Nortadalafil;4-b]indole-1;(6R-trans)-6-(1;DeMethyltadalafil;N-demethyltadalafil;Tadalafil IMpurity J;N-DesMethyl Tadalafil;Tadalafil Impurity 21;N-Demethyl Tildenafil;Tildenafil Impurity 7

CBNumber:: CB92549609

Molecular Formula:: C21H17N3O4

Molecular Weight:: 375.38

MDL Number:: MFCD19443817

MOL File:: 171596-36-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:46:24

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Nortadalafil Properties

Melting point	285-290℃ (methanol )
Boiling point	718.6±60.0 °C(Predicted)
Density	1.55±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	Solid
pka	13.53±0.40(Predicted)
color	White to Pale Yellow
InChI	InChI=1S/C21H17N3O4/c25-18-9-22-21(26)15-8-13-12-3-1-2-4-14(12)23-19(13)20(24(15)18)11-5-6-16-17(7-11)28-10-27-16/h1-7,15,20,23H,8-10H2,(H,22,26)/t15-,20-/m1/s1
InChIKey	XHDLVMPUSXRZOS-FOIQADDNSA-N
SMILES	N1C2=C(C=CC=C2)C2C[C@]3([H])C(=O)NCC(=O)N3[C@H](C3=CC=C4OCOC4=C3)C1=2
FDA UNII	5W59DMB3LD

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS07,GHS09
Signal word	Danger
Hazard statements	H302+H312-H314-H317-H410
Precautionary statements	P501-P273-P272-P260-P270-P264-P280-P391-P362+P364-P303+P361+P353-P333+P313-P301+P330+P331-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405

Nortadalafil price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0823	Nortadalafil ≥98%	171596-36-4	50mg	$15	2026-06-04	Buy
ChemScene	CS-0823	Nortadalafil ≥98%	171596-36-4	250mg	$26	2026-06-04	Buy
ChemScene	CS-0823	Nortadalafil ≥98%	171596-36-4	1g	$51	2026-06-04	Buy
ChemScene	CS-0823	Nortadalafil ≥98%	171596-36-4	5g	$157	2026-06-04	Buy
ChemScene	CS-0823	Nortadalafil ≥98%	171596-36-4	5mg	$9168	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0823	50mg	$15	Buy
CS-0823	250mg	$26	Buy
CS-0823	1g	$51	Buy
CS-0823	5g	$157	Buy
CS-0823	5mg	$9168	Buy

Nortadalafil Chemical Properties, Uses, Production

Uses

A N-desmethyl analogue of the human PDE5 inhibitor Tadalafil (T004500). A potential antiplasmodial drug.

Biological Activity

the cgmp-specific pde5 is the major pde isozyme in the corpus cavernosum, and controls penile erection. the pde5 inhibitors used in the clinic amplify the no-ccmp pathway and enhance the normal process leading to penile erection.nortadalafil is demethyl tadalafil, which is a pde5 inhibitor currently marketed in pill form for treating erectile dysfunction under the name cialis and for the treatment of pulmonary arterial hypertension under the name adcirca.

in vitro

tadalafil has been identified as a highly potent pde5 inhibitor (ic50 = 5 nm) with high selectivity for pde5 vs pde1-4 and pde6. it displays 85-fold greater selectivity vs pde6 than sildenafil [1].

in vivo

tadalafil showed profound and long-lasting blood pressure lowering activity (30 mmhg/>7 h) in the spontaneously hypertensive rat model after oral administration (5 mg/kg) [1].

target

PDE5

IC 50

n/a for nortadalafil; 5 nm for tadalafil

References

[1] daugan a, grondin p, ruault c, le monnier de gouville ac, coste h, linget jm, kirilovsky j, hyafil f, labaudinière r. the discovery of tadalafil: a novel and highly selective pde5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. j med chem. 2003;46(21):4533-42.
[2] porst h, hell-momeni k, büttner h. chronic pde-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. expert opin pharmacother. 2012 jul;13(10):1481-94. doi: 10.1517/14656566.2012.693162.

Nortadalafil synthesis

Synthesis of Nortadalafil from (1R,3R)-Methyl-1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate

Nortadalafil Preparation Products And Raw materials

Raw materials

Chloropretadalafil (1R,3R)-Methyl-1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate

Preparation Products

Nortadalafil Suppliers

Global Suppliers ( 152)

Supplier	Tel	Email	Country	ProdList	Advantage
Guangzhou Dihao Medical Technology Co., Ltd	18602015453	2667751176@qq.com	China	479	58
Shandong longtai fine chemical co., ltd	15169750147	1908452573@qq.com	China	47	58
Henan Wasai Biological Technology Co. LTD	13526611694	2582571190@qq.com	China	67	58
Shandong Wankang Biotechnology Co. , Ltd.	131-7317-1119 13173171119	918582503@qq.com	China	23	58
JinanGongchuang Pharmaceutical Technology Co. Ltd..	88065293 13287783460	3166282224@qq.com	China	40	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Nanjing Chemipioneer Pharma& Tech Co., LTD	025-52643182 13914798241;	zhoulq@chemipioneer.com.cn	China	92	62
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61

Supplier	Advantage
Guangzhou Dihao Medical Technology Co., Ltd	58
Shandong longtai fine chemical co., ltd	58
Henan Wasai Biological Technology Co. LTD	58
Shandong Wankang Biotechnology Co. , Ltd.	58
JinanGongchuang Pharmaceutical Technology Co. Ltd..	58
J & K SCIENTIFIC LTD.	76
Chemsky（shanghai）International Co.,Ltd.	50
Nanjing Chemipioneer Pharma& Tech Co., LTD	62
BOC Sciences	65
Haoyuan Chemexpress Co., Ltd.	61

View Latest Price from Nortadalafil manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	Nortadalafil 171596-36-4		1kg	99.0%	500kg	Jinan Hong Kongda Chemical Co.,LTD
2026-09-18	Nortadalafil 171596-36-4	$10.00	1ASSAYS	99%	1 ton	RongNa Biotechnology Co.,Ltd
2026-08-25	Nortadalafil 171596-36-4		1kg	99%	500 kg	Xi an Biohorlden Industry Trade Co Ltd

Nortadalafil
171596-36-4
$0.00
99.0%
Jinan Hong Kongda Chemical Co.,LTD

Nortadalafil
171596-36-4
$10.00
99%
RongNa Biotechnology Co.,Ltd

Nortadalafil
171596-36-4
99%
Xi an Biohorlden Industry Trade Co Ltd

Nortadalafil Spectrum

Nortadalafil(171596-36-4)¹HNMR

171596-36-4 (Nortadalafil) Related Search:

Tetryzoline (1R,3R)-2-acetyl-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro- 1H-pyrido[3,4-b]indole-3-carboxylate (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester

(1S,3R)-1-Benzo[1,3]dioxol-5-yl-2-(2-chloro-acetyl)-2,3,4,9-tetrahydro-1H-b-carboline-3-carboxylic Acid Methyl Ester 2-Hydroxypropyl Nortadalafil cis-ent-Tadalafil (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(dimethylglycyl)-2,3,4,9-tetrahydro-1H-pyrido [3,4-b]indole-3-carboxylate methyl (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester

Chloropretadalafil cis-Tadalafil D(+)-Tryptophan Tadalafil iMpurity B Tadalafil KetolactaM

Tadalafil JLEQLXGZAIAEFX-VRQJEYPFSA-N Tadalafil EP Impurity

1of4

DeMethyltadalafil N-DesMethyl Tadalafil (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Tadalafil Impurity 21 (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Nortadalafil Tadalafil IMpurity:IMpurity C Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-, (6R,12aR)- (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, N-DesMethyl Tadalafil Tadalafil IMpurity J Tadanafil N-desmethyl impurity Tetrahydropalmatine Solution, 100ppm Tadalafil Impurity 21(N-Desmethyl Tadalafil) Nortadalafil Solution in Methanol, 100μg/mL N-demethyltadalafil (6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione? (Tadalafil Impurity) (6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Nortadalafil/Demethyl Tadalafil N-Desmethyl tadalafil in methanol Demethyltadalafil impurity Nortadalafil, 10 mM in DMSO (6R-trans)-6-(1 12a-hexahydropyrazino[1' 4-b]indole-1 N-Demethyl Tildenafil Tildenafil Impurity 7 Nortadalafil (Standard) 171596-36-4 172596-36-4 Aromatics Drug Analogues Heterocycles Indole Derivatives Inhibitors Intermediates & Fine Chemicals Pharmaceuticals