4-Quinolone-3-Carboxamide Furan CB2 Agonist
- CAS No.
- 1314230-75-5
- Chemical Name:
- 4-Quinolone-3-Carboxamide Furan CB2 Agonist
- Synonyms
- CB2 receptor agonist 2;4-Quinolone-3-Carboxamide Furan CB2 Agonist;N-(1-adamantyl)-6-(furan-2-yl)-8-methoxy-4-oxo-1-pentylquinoline-3-carboxamide;3-Quinolinecarboxamide, 6-(2-furanyl)-1,4-dihydro-8-methoxy-4-oxo-1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-
- CBNumber:
- CB92590045
- Molecular Formula:
- C30H36N2O4
- Molecular Weight:
- 488.62
- MDL Number:
- MOL File:
- 1314230-75-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
4-Quinolone-3-Carboxamide Furan CB2 Agonist price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11094 | 4-Quinolone-3-Carboxamide Furan CB2 Agonist ≥98% | 1314230-75-5 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 11094 | 4-Quinolone-3-Carboxamide Furan CB2 Agonist ≥98% | 1314230-75-5 | 5mg | $193 | 2024-03-01 | Buy |
| Biosynth | PCC23075 | N-(1-Adamantyl)-6-(furan-2-yl)-8-methoxy-4-oxo-1-pentylquinoline-3-carboxamide | 1314230-75-5 | 2mg | $194.7 | 2026-06-04 | Buy |
| Biosynth | PCC23075 | N-(1-Adamantyl)-6-(furan-2-yl)-8-methoxy-4-oxo-1-pentylquinoline-3-carboxamide | 1314230-75-5 | 5mg | $414.2 | 2026-06-04 | Buy |
| Biosynth | PCC23075 | N-(1-Adamantyl)-6-(furan-2-yl)-8-methoxy-4-oxo-1-pentylquinoline-3-carboxamide | 1314230-75-5 | 10mg | $662.7 | 2026-06-04 | Buy |
4-Quinolone-3-Carboxamide Furan CB2 Agonist Chemical Properties, Uses, Production
Uses
CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a Ki of 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2[1].
Biological Activity
ki: 8.5 nm4-quinolone-3-carboxamide furan cb2 agonist is a high-affinity ligand of cb2.the endocannabinoid system consists of endogenous cannabinoids (endocannabinoids), cannabinoid receptors (primarily cb1 and cb2), and the enzymes that synthesize and degrade endocannabinoids.
in vitro
previous study found that 4-quinolone-3-carboxamide furan cb2 agonist (4g) was devoid of any potential “indirect” agonist activity at cannabinoid receptors, exerted by prolonging the lifespan of endocannabinoids because 4g at up to a 10 μm concentration did not inhibit anandamide or 2-ag degradation by faah or magl, respectively. in cytotosicity study, 4g was tested at 1 μm and the results showed that it exhibited very low or no cytotoxicity, the cell viability being above 95% after a 72 h treatment [1].
in vivo
in animal study, 4g was found to have antinociceptive activity in the formalin test in mice. moreover, 4g was very potent with maximal effect being reached at the 1 mg/kg dose and efficacious also on the first phase of the nocifensive response. the effect of 4g could be strongly reduced by the addition of am630, a cb2-selective antagonist/inverse agonist, therefore demonstrating that 4g might act as a potent and selective cb2 agonist [1].
IC 50
CB2: 8.5 nM (Ki)
References
[1] s. pasquini, m. de rosa, v. pedani, et al. investigations on the 4-quinolone-3-carboxylic acid motif. 4. identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice. journal of medicinal chemistry 54, 5444-5453 (2011).
4-Quinolone-3-Carboxamide Furan CB2 Agonist Preparation Products And Raw materials
Raw materials
Preparation Products
4-Quinolone-3-Carboxamide Furan CB2 Agonist Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | +86-0513; 18051384581 | sales@chemhifuture.com | China | 3075 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
View Latest Price from 4-Quinolone-3-Carboxamide Furan CB2 Agonist manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | CB2 receptor agonist 2
1314230-75-5
|
$118.00-281.00 | 99.75% | 10g | TargetMol Chemicals Inc. |
-
- CB2 receptor agonist 2
1314230-75-5
- $118.00-281.00
- 99.75%
- TargetMol Chemicals Inc.
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