1-[4-[1-[4-(AMinosulfonyl)phenyl]-3-(trifluoroMethyl)-1H-pyrazol-5-yl]benzoate] β-D-Glucopyranuronic Αcid
![1-[4-[1-[4-(AMinosulfonyl)phenyl]-3-(trifluoroMethyl)-1H-pyrazol-5-yl]benzoate] β-D-Glucopyranuronic Αcid Structure](CAS/GIF/264236-79-5.gif)
- CAS No.
- 264236-79-5
- Chemical Name:
- 1-[4-[1-[4-(AMinosulfonyl)phenyl]-3-(trifluoroMethyl)-1H-pyrazol-5-yl]benzoate] β-D-Glucopyranuronic Αcid
- Synonyms
- Celecoxib metabolite M1;Celecoxib carboxylic acid glucuronide;Celecoxib Carboxylic Acid Acyl-β-D-glucuronide;Celecoxib carboxylic acid acyl-b-D-glucuronide;Celecoxib Carboxylic Acid-Acyl-beta-D-Glucuronide;Celecoxib carboxylic acid-acyl-beta-D-glucuronide min. 95%;1-[4-[1-[4-(AMinosulfonyl)phenyl]-3-(trifluoroMethyl)-1H-pyrazol-5-yl]benzoate] β-D-Glucopyranuronic Αcid;β-D-Glucopyranuronic acid, 1-[4-[1-[4-(aminosulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]benzoate];(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[4-[2-(4-sulfamoylphenyl)-5-(trifluoromethyl)pyrazol-3-yl]benzoyl]oxyoxane-2-carboxylic acid;3,4,5-Trihydroxy-6-((4-(1-(4-sulfamoylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)benzoyl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
- CBNumber:
- CB92621747
- Molecular Formula:
- C23H20F3N3O10S
- Molecular Weight:
- 587.48
- MDL Number:
- MFCD28138278
- MOL File:
- 264236-79-5.mol
1-[4-[1-[4-(AMinosulfonyl)phenyl]-3-(trifluoroMethyl)-1H-pyrazol-5-yl]benzoate] β-D-Glucopyranuronic Αcid Properties
| Melting point | >147°C (dec.) |
|---|---|
| Boiling point | 836.7±75.0 °C(Predicted) |
| Density | 1.77±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Methanol (Slightly, Heated) |
| pka | 2.66±0.70(Predicted) |
| form | Solid |
| color | Off-White to Pale Yellow |
| Stability | Hygroscopic |
| FDA UNII | U914CMX58G |
1-[4-[1-[4-(AMinosulfonyl)phenyl]-3-(trifluoroMethyl)-1H-pyrazol-5-yl]benzoate] β-D-Glucopyranuronic Αcid price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22457 | Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide ≥95% | 264236-79-5 | 500μg | $113 | 2024-03-01 | Buy |
| Cayman Chemical | 22457 | Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide ≥95% | 264236-79-5 | 1mg | $214 | 2024-03-01 | Buy |
| Usbiological | 292911 | Celecoxib carboxylic acid acyl-b-D-glucuronide | 264236-79-5 | 1mg | $616 | 2021-12-16 | Buy |
| TRC | C251015 | CelecoxibCarboxylicAcidAcyl-β-D-glucuronide | 264236-79-5 | 10mg | $1695 | 2021-12-16 | Buy |
| Biosynth Carbosynth | MC16649 | Celecoxib carboxylic acid acyl-b-D-glucuronide | 264236-79-5 | 25mg | $3625 | 2021-12-16 | Buy |
1-[4-[1-[4-(AMinosulfonyl)phenyl]-3-(trifluoroMethyl)-1H-pyrazol-5-yl]benzoate] β-D-Glucopyranuronic Αcid Chemical Properties,Uses,Production
Description
Celecoxib carboxylic acid acyl-β-D-glucuronide is a phase II metabolite of celecoxib . Celecoxib is an anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits cyclooxygenase-2 (COX-2; IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively). Celecoxib carboxylic acid acyl-β-D-glucuronide is a minor metabolite, accounting for 2% of the administered dose in human urine and rat bile.
Uses
Celecoxib Carboxylic Acid Acyl-β-D-glucuronide is a glucuronide metabolite of Celecoxib (C251000), a Cox-2 inhibitor.
References
[1] S K PAULSON. Metabolism and excretion of [(14)C]celecoxib in healthy male volunteers.[J]. Drug Metabolism and Disposition, 2000, 28 3: 308-314.
[2] YONG MA Ming H Song Gao. Quantitation of celecoxib and four of its metabolites in rat blood by UPLC-MS/MS clarifies their blood distribution patterns and provides more accurate pharmacokinetics profiles[J]. Journal of Chromatography B, 2015, 1001: Pages 202-211. DOI: 10.1016/j.jchromb.2015.07.026
[3] Y. AMY SIU . Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variants[J]. Drug Metabolism and Pharmacokinetics, 2018, 33 5: Pages 219-227. DOI: 10.1016/j.dmpk.2018.06.001
1-[4-[1-[4-(AMinosulfonyl)phenyl]-3-(trifluoroMethyl)-1H-pyrazol-5-yl]benzoate] β-D-Glucopyranuronic Αcid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 94644 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9679 | 58 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8065 | 58 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 18234 | 56 |
| Nanjing XiZe Biotechnology CO., Ltd. | 025-66023220 0086-15250997978 | 1511893459@qq.com | China | 4836 | 55 |
View Lastest Price from 1-[4-[1-[4-(AMinosulfonyl)phenyl]-3-(trifluoroMethyl)-1H-pyrazol-5-yl]benzoate] β-D-Glucopyranuronic Αcid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-30 | Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide
264236-79-5
|
US $535.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide
264236-79-5
- US $535.00 / mg
- TargetMol Chemicals Inc.
264236-79-5(1-[4-[1-[4-(AMinosulfonyl)phenyl]-3-(trifluoroMethyl)-1H-pyrazol-5-yl]benzoate] β-D-Glucopyranuronic Αcid)Related Search:
1of4
