Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol

8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol

8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol Structure
8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol structure
CAS No.
66336-42-3
Chemical Name:
8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol
Synonyms
8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol;1,4-Dioxaspiro[4.5]decan-8-ol, 8-methyl-
CBNumber:
CB92660025
Molecular Formula:
C9H16O3
Molecular Weight:
172.22
MDL Number:
MFCD11108667
MOL File:
66336-42-3.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:53
Request For Quotation

8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol Properties

Melting point 70-71 °C
Boiling point 267.7±40.0 °C(Predicted)
Density 1.14±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka 15.18±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P233-P261-P280-P301+P330+P331-P302+P352-P304+P340-P305+P351+P338-P309+P311

8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M451020 8-Methyl-1,4-dioxaspiro[4.5]decan-8-ol 66336-42-3 100mg $200 2021-12-16 Buy
Matrix Scientific 125509 8-Methyl-1,4-dioxaspiro[4.5]decan-8-ol 97% 66336-42-3 5g $910 2021-12-16 Buy
AK Scientific 1384CY 8-Methyl-1,4-dioxaspiro[4.5]decan-8-ol 66336-42-3 250mg $109 2021-12-16 Buy
Matrix Scientific 125509 8-Methyl-1,4-dioxaspiro[4.5]decan-8-ol 97% 66336-42-3 1g $260 2021-12-16 Buy
AK Scientific 1384CY 8-Methyl-1,4-dioxaspiro[4.5]decan-8-ol 66336-42-3 5g $284 2021-12-16 Buy
Product number Packaging Price Buy
M451020 100mg $200 Buy
125509 5g $910 Buy
1384CY 250mg $109 Buy
125509 1g $260 Buy
1384CY 5g $284 Buy

8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol Chemical Properties,Uses,Production

Uses

8-Methyl-1,4-dioxaspiro[4.5]decan-8-ol is used in preparation of pyrrolopyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases.

Synthesis

1,4-Dioxaspiro[4.5]decan-8-one

4746-97-8

Methyllithium

917-54-4

8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol

66336-42-3

Step 1: Synthesis of 8-methyl-1,4-dioxaspiro[4.5]decan-8-ol: 1,4-dioxaspiro[4.5]decan-8-one (7.8 g, 50.0 mmol) was dissolved in dry THF (75 mL) and cooled to -78 °C under argon protection. Methyl lithium solution (1.5 M in ether, 43.3 mL, 65.0 mmol) was added slowly, controlling the reaction temperature to not exceed -55 °C. After addition, the reaction mixture was continued to be stirred at -55 °C for 4 hours. Subsequently, the reaction system was slowly warmed to room temperature and the reaction was quenched with saturated NH4Cl solution. The organic layer was separated and concentrated in vacuum, and the resulting residue was purified by silica gel column chromatography (eluent ratio: ethyl acetate:petroleum ether = 1:9 to 1:3) to afford the target product, 8-methyl-1,4-dioxaspiro[4.5]decan-8-ol, as a white solid (6.8 g, yield: 80%).

References

[1] Canadian Journal of Chemistry, 1997, vol. 75, # 6, p. 656 - 664
[2] Patent: WO2014/9302, 2014, A1. Location in patent: Page/Page column 89
[3] Patent: US2015/158879, 2015, A1. Location in patent: Paragraph 0437; 0438
[4] Patent: US2016/200741, 2016, A1. Location in patent: Paragraph 0438-0439
[5] Patent: WO2008/119716, 2008, A1. Location in patent: Page/Page column 49

8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol Preparation Products And Raw materials

Raw materials

1,4-Dioxaspiro[4.5]decan-8-one Methyllithium Phenylmagnesium bromide Methylmagnesium Bromide Methylmagnesium chloride

Preparation Products

8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol Suppliers

Global( 51)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29804 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
Nanjing Bicbiotechnology Co., Ltd 		+86-2552131256 +86-18251840740 sales@bicbiotech.com China 5994 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39003 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7908 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42953 64
ChemShuttle, Inc. 0150-83588313-811 18800520310 sales@chemshuttle.com China 2999 62
Supplier Advantage
career henan chemical co 		58
Nextpeptide Inc 		58
Labnetwork lnc. 		58
Nanjing Bicbiotechnology Co., Ltd 		58
Aladdin Scientific 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Amadis Chemical Company Limited 		58
Tetranov Biopharm 64
Shanghai Hanhong Scientific Co.,Ltd. 64
ChemShuttle, Inc. 62

View Lastest Price from 8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol pictures 2020-01-15 8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol
66336-42-3
 US $1.00 / KG 1KG 99.0% 100kg Career Henan Chemical Co

8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol Spectrum

8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol(66336-42-3)1HNMR8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol(66336-42-3)1HNMR
8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol 1,4-Dioxaspiro[4.5]decan-8-ol, 8-methyl- 66336-42-3