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1,4-Dioxaspiro[4.5]decan-8-one

1,4-Dioxaspiro[4.5]decan-8-one Structure
1,4-Dioxaspiro[4.5]decan-8-one structure
CAS No.
4746-97-8
Chemical Name:
1,4-Dioxaspiro[4.5]decan-8-one
Synonyms
1,4-CYCLOHEXANEDIONE MONOETHYLENE ACETAL;cyclohexanedione monoethylene ketal;1,4-CYCLOHEXANEDIONE MONOETHYLENE KETAL;1,4-Cyclohexanedione ethylene ketal;Cyclohexane-1,4-dione monoethylene ketal;1 4-dioxiro[4.5]decan-8-one pharmaceutical intermediate;KEHK;4-Cyclohexanedione Mo;cyclohexanedione monoacetal;4-Dioxaspiro[4.5]decan-8-one
CBNumber:
CB3496677
Molecular Formula:
C8H12O3
Molecular Weight:
156.18
MDL Number:
MFCD00010214
MOL File:
4746-97-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:26:21
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1,4-Dioxaspiro[4.5]decan-8-one Properties

Melting point 70-73 °C (lit.)
Boiling point 112C
Density 1.0887 (rough estimate)
refractive index 1.4430 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Soluble in chloroform & methanol.
form Crystalline Powder or Crystals
color White to beige
Sensitive Moisture Sensitive
BRN 117631
InChI InChI=1S/C8H12O3/c9-7-1-3-8(4-2-7)10-5-6-11-8/h1-6H2
InChIKey VKRKCBWIVLSRBJ-UHFFFAOYSA-N
SMILES O1C2(CCC(=O)CC2)OCC1
CAS DataBase Reference 4746-97-8(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36/37/39-26
WGK Germany  3
F  8-10-21
Hazard Note  Irritant
HS Code  29110000
Storage Class 11 - Combustible Solids
NFPA 704
1
2 0

1,4-Dioxaspiro[4.5]decan-8-one price More Price(110)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 274879 1,4-Cyclohexanedione monoethylene acetal 97% 4746-97-8 5g $46.1 2026-04-30 Buy
Sigma-Aldrich 274879 1,4-Cyclohexanedione monoethylene acetal 97% 4746-97-8 25g $85.2 2026-04-30 Buy
TCI Chemical C1292 1,4-Cyclohexanedione Monoethyleneketal >98.0%(GC) 4746-97-8 5g $19 2026-04-30 Buy
TCI Chemical C1292 1,4-Cyclohexanedione Monoethyleneketal >98.0%(GC) 4746-97-8 25g $42 2026-04-30 Buy
Usbiological 269023 1,4-Cyclohexanedione monoethlylene acetal Asreported 4746-97-8 50g $333 2026-06-03 Buy
Product number Packaging Price Buy
274879 5g $46.1 Buy
274879 25g $85.2 Buy
C1292 5g $19 Buy
C1292 25g $42 Buy
269023 50g $333 Buy

1,4-Dioxaspiro[4.5]decan-8-one Chemical Properties,Uses,Production

Chemical Properties

1,4-Dioxaspiro[4.5]decan-8-one is white to beige crystalline powder or crystals

Uses

1,4-Dioxaspiro[4.5]decan-8-one is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione Monoethylene Acetal is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.

Uses

1,4-Cyclohexanedione is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.

Uses

Intermediates of Liquid Crystals

Application

1,4-Dioxaspiro[4.5]decan-8-one can be used:
(1) Used in a study of microwave-assisted reductive amination.
(2) Via a novel aromatization process, this bicyclic frame can be converted into a series of 5-alkoxytryptamine derivatives including serotonin, melatonin and bufotenin.

Synthesis

In a dry Schlenk tube, [Rh(cod)Cl]2 (9.9 mg, 20.0 mol), (R)-Binap (27.4 mg, 44.0 mol), and Durum (20.0 mg, internal standard) were dissolved in CH2Cl2 (8.0 mL); then, 2 mmol of the substrate was added to the solution at room temperature under nitrogen. After stirring for 1 min, CF3CO2Ag (8.8 mg, 40.0 mol) was added to the mixture. The solution was stirred at 25C under nitrogen and monitored by GC or HPLC to determine the conversion and ee values. After evaporation of the solvent, the residue was purified by chromatography using EtOAc/hexane (20/80) as eluent to give the product 1,4-cyclohexanedione monoethylene glycol ketal.

Purification Methods

Recrystallise it from pet ether. It sublimes slowly on attempted distillation. Also purify it by dissolving it in Et2O and adding pet ether (b 60-80o) until turbid and cooling. [Gardner et al. J Am Chem Soc 22 1206 1957, Britten & Lockwood J Chem Soc Perkin Trans 1 1824 1974.] [Beilstein 19/4 V 93.]

1,4-Dioxaspiro[4.5]decan-8-one synthesis

6289-46-9
107-21-1
4746-97-8
Synthesis of 1,4-Dioxaspiro[4.5]decan-8-one from 2,5-dioxo-1,4-cyclohexanedicarboxylic acid dimethyl ester and Ethylene glycol

1,4-Dioxaspiro[4.5]decan-8-one Preparation Products And Raw materials

Raw materials

Preparation Products

4,4-Difluorocyclohexanone methyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexen-1-yl]-morpholine Pramipexole impurity 7 4-(tert-Butyldimethylsilyloxy)cyclohexa&
4-Methoxycyclohexanol 4-(Benzyloxy)cyclohexanone 4-Pentylcyclohexanone INCB8761(PF-4136309) 4-Propylcyclohexanone
4-Cyanocyclohexanone cyclic ethylene acetal 4-Methoxycyclohexanon

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1,4-Dioxaspiro[4.5]decan-8-one Suppliers

Global( 612)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Maison Chemical Co.,Ltd. 155-11852758; 18408670720 ruby@maisonchem.com.cn China 687 58
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
XIANAONARUNNEWMATERIALCo.,Ltd 029-81509060 13629280593 2074901304@qq.com China 185 58
Xi'an Qingxiang Biotechnology Co., Ltd 029-18192656670 18192656670 2557411153@qq.com China 189 58
Xi 'an billiton biological technology co., LTD 029-88764766 chen.zeshan@xatuochao.com China 521 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Supplier Advantage
Hebei Maison Chemical Co.,Ltd. 58
Beijing Ouhe Technology Co., Ltd 60
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
XIANAONARUNNEWMATERIALCo.,Ltd 58
Xi'an Qingxiang Biotechnology Co., Ltd 58
Xi 'an billiton biological technology co., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
future industrial shanghai co., ltd 65

Related articles

View Lastest Price from 1,4-Dioxaspiro[4.5]decan-8-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,4-Cyclohexanedione monoethyleneacetal pictures 2026-09-11 1,4-Cyclohexanedione monoethyleneacetal
4746-97-8
 $20.00 1KG 99% 300 Tons/ year Speranza Chemical Co., Ltd.
1,4-Dioxaspiro[4.5]decan-8-one pictures 2026-09-11 1,4-Dioxaspiro[4.5]decan-8-one
4746-97-8
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
1,4-Dioxaspiro[4.5]decan-8-one pictures 2026-08-12 1,4-Dioxaspiro[4.5]decan-8-one
4746-97-8
 $289.00 1KG 98% 1-10MT Baoji Guokang Healthchem Co., Ltd.

1,4-Dioxaspiro[4.5]decan-8-one Spectrum

1,4-Dioxaspiro[4.5]decan-8-one(4746-97-8)MS1,4-Dioxaspiro[4.5]decan-8-one(4746-97-8)1HNMR1,4-Dioxaspiro[4.5]decan-8-one(4746-97-8)13CNMR1,4-Dioxaspiro[4.5]decan-8-one(4746-97-8)IR11,4-Dioxaspiro[4.5]decan-8-one(4746-97-8)IR21,4-Dioxaspiro[4.5]decan-8-one(4746-97-8)Raman

4746-97-8(1,4-Dioxaspiro[4.5]decan-8-one)Related Search:

2-Bromomethyl-1,3-dioxolane Decane 1,4-Dioxane Selenium dioxide Buspirone
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Dioxopromethazine 2-Methyl-1,3-dioxolane 2,2-Dimethyl-1,3-dioxolane 4-Hydroxycyclohexanone 1,1-Dimethoxycyclohexane
Hexanal dimethyl acetal 2-Ethyl-2-methyl-1,3-dioxolane 3-Acetyl-1-propanol

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1,4-cyclohexanedione monoacetal Substituted 1,2,4,9-tetrahydrospiro[carbazole-3,2'-[1,3]dioxane] 1,4-Cyclohexanedione monoethlylene acetal 1,4-Cyclohexanedione monoethylene ketal for synthesis 4-Dioxaspiro[4.5]decan-8-one 1,4-Cyclohexanedion monoethylene acetal 1,4-Dioxiro[4.5]decan-8-one. 1,4-Cyclohexanedione ethylene ketal 1,4-CYCLOHEXANEDIONE MONOETHYLENE ACETAL (1,4-DIOXASPIRO(4.5)DECAN-8-ONE) 1,4-Dioxaspiro[4.5]decan-8-one, Cyclohexane-1,4-dione monoethylene ketal Cyclohexane-1,4-dione monoethylene acetal KEHK 1,4-Dioxaspiro[4.5]decan-8-one ,99% 1,4-DIOXASPIRO[4.5]DECAN-8-ONE 1,4-DIOXASPIRO[4.5]-8-DECANONE CYCLOHEXANEDIONE(1,4-) MONOETHYLENE 4-Cyclohexanedione Monoethylene acetal 1,4-Dioxaspiro[4.5]decan-8-one 99% Cyclohexane-1,4-dione monoethylene ketal, Cyclohexane-1,4-dione monoethylene acetal 1,4-Cyclohexanedion Monoethyl 1,4-Dioxaspiro[4.5]decan-8-one, 98% 25GR Cyclohexane-1,4-dione monoethylene ketal, 8-Oxo-1,4-dioxaspiro[4.5]decane Ethylene glycolcyclohexanoneketalsingleloop 1,4- 1,4-Cyclohexanedione Monoethylene acetal 97% 1,4-Dioxaspiro[4.5]decan-8-one, 95+% 1,4-Dioxaspiro[4.5]decane-8-one- 4,4-(Ethylenebisoxy)cyclohexan-1-one 7,10-Dioxaspiro[5.4]decane-3-one Spiro[cyclohexane-1,2'-1,3-dioxolane]-4-one 1,4-Cyclohexanedione monoethylene acetal (1,4-Dioxaspiro(4 x 5)d Cyclohexanedione monoethyleneacetal 1,4-Dioxaspiro[4.5]decan-8-one,98% 1, 4 - cyclohexanol diketone glycol ketal 1,4-Dioxaspiro[4,5!decan-8-one, 97+% Cyclohexane-1,4-dione monoethylene acetal 99% Monoethylene glycol 1,4- cyclohexyl diketone 4-Cyclohexanedione Mo 1,4-cyclohexanedione monoethylene ketal 4746-97-8 1,4-Cyclohexanedione Monoethyleneketal > 1,4 cyclohexanedione monoethylene glycol acetophenone 1,4-Cyclohexanedione monoketal 1,4-Dioxaspiro[4.5]decan-8-one(4746-97-8) 1,4-Dioxaspiro[4.5]decan-8-one/1,4-Cyclohexanedione Monoethylene Ketal 1,4-Dioxaspiro[4.5]decan-8-one (6CI, 7CI, 8CI, 9CI, ACI) 1,4-CYCLOHEXANEDIONE MONOETHYLENE KETAL > 97% puriss for synthesis 1,4-Cyclohexanedione monoethylene cyclohexanedione monoacetal 1.4-Cyclohexanedione monoethylene glycol ketal KCR 1,4-Cyclohexanedioneglycolmonoketal 1,4-Dioxaspiro[4.5]decan-8-one - [D7118] 1,4-Cyclohexanedione Monoethylene Acetal(KCR) 1,4-CYCLOHEXANEDIONE MONOETHYLENE ACETAL 1 4-dioxiro[4.5]decan-8-one pharmaceutical intermediate 1,4-CYCLOHEXANEDIONE MONOETHYLENE KETAL Cyclohexane-1,4-dione monoethylene ketal cyclohexanedione monoethylene ketal 1,4-Cyclohexanedione monoethylketal 4746-97-8