Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
- CAS No.
- 1195768-19-4
- Chemical Name:
- Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
- Synonyms
- DABRAFENIB INT;Dalafenib intermediate 3;3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate;Methyl 3-(2,6-difluorophenylsulfonaMido)-2-fluorobenzoate;Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate;methyl 3-(((2,6-difluorophenyl)sulfonyl)amino)-2-fluorobenzo...;Methyl 3-{[(2,6-difluorophenyl)sulfonyl]aMino}-2-fluorobenzoate;Benzoic acid, 3-[[(2,6-difluorophenyl)sulfonyl]amino]-2-fluoro-, methyl ester
- CBNumber:
- CB92703779
- Molecular Formula:
- C14H10F3NO4S
- Molecular Weight:
- 345.29
- MDL Number:
- MFCD18447698
- MOL File:
- 1195768-19-4.mol
| Product description | Number | Pack Size | Price |
| Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate | 8353DN | 250mg | $123 |
| Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate 95+% | CD12174605 | 1g | $248 |
| Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate 95+% | CD12174605 | 5g | $743 |
| Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate | 1195768194 | 5g | $787.5 |
| More product size | |||
| Boiling point | 445.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.507±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 6.68±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C14H10F3NO4S/c1-22-14(19)8-4-2-7-11(12(8)17)18-23(20,21)13-9(15)5-3-6-10(13)16/h2-7,18H,1H3 |
| InChIKey | COSCWKICERLCEK-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC=CC(NS(C2=C(F)C=CC=C2F)(=O)=O)=C1F |
Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 8353DN | Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate | 1195768-19-4 | 250mg | $123 | 2021-12-16 | Buy |
| Crysdot | CD12174605 | Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate 95+% | 1195768-19-4 | 1g | $248 | 2021-12-16 | Buy |
| Crysdot | CD12174605 | Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate 95+% | 1195768-19-4 | 5g | $743 | 2021-12-16 | Buy |
| Alichem | 1195768194 | Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate | 1195768-19-4 | 5g | $787.5 | 2021-12-16 | Buy |
Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate Chemical Properties,Uses,Production
Uses
Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate can be useful in the development of B-RafV600E inhibitors.
Synthesis
Methyl 3-amino-2-fluorobenzoate was charged to the reactor, followed by dichloromethane. The contents were stirred and cooled to ~15°C, and pyridine was added. After that, the reactor contents were adjusted to ~15°C, and adding 2,6-diflurorobenzenesulfonyl chloride was started via an addition funnel. The temperature during addition was kept at <25°C. After complete addition, the reactor contents were warmed to 20-25°C and held overnight. Ethyl acetate was added, and dichloromethane was removed by distillation. Once distillation was complete, the reaction mixture was diluted again with ethyl acetate (5 vol) and concentrated. Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate was obtained through further purification.![Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate](/NewsImg/2023-12-06/6383747428389984808211694.jpg "Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate")
storage
Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
References
[1] Patent: WO2011/47238, 2011, A1. Location in patent: Page/Page column 17-18
[2] Patent: WO2014/66606, 2014, A2. Location in patent: Page/Page column 20-21
[3] Patent: WO2014/195852, 2014, A1. Location in patent: Page/Page column 28-29
[4] Patent: WO2015/87279, 2015, A1. Location in patent: Page/Page column 21; 22
[5] Patent: WO2017/37587, 2017, A1. Location in patent: Page/Page column 31-32
Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Enki Biopharmaceuticals (Shanghai) Limited | +86-0086-2157680326 +8613916707528 | yusu@enkibiopharma.com | China | 51 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 10996 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 340 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Zison Pharmaceutical (Shandong) Co., Ltd. | +86-0086-531-88259693 +86-18660188356 | tracy.li@zisonpharm.com | China | 84 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-17392712697 | 1022@dideu.com | China | 3996 | 58 |
View Lastest Price from Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-10 | Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
1195768-19-4
|
US $0.00 / kg | 0.1kg | 99.9% | 40-80kgs | Zison Pharmaceutical (Shandong) Co., Ltd. | |
![Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate pictures](/ProductImageEN/2023-10/Small/c9552ebe-0977-4d3b-b516-7bdf590587af.jpg) |
2025-06-03 | Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate
1195768-19-4
|
US $50.00-500.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
![Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate pictures](/ProductImageEN/2022-09/Small/11da0bf0-5f25-4c63-9a17-e634adafd1c5.png) |
2025-04-04 | Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate
1195768-19-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
-
- Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
1195768-19-4
- US $0.00 / kg
- 99.9%
- Zison Pharmaceutical (Shandong) Co., Ltd.
-
- Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate
1195768-19-4
- US $50.00-500.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate
1195768-19-4
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
