(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester
- CAS No.
- 1092522-02-5
- Chemical Name:
- (4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester
- Synonyms
- tert-Butyl (4-aminophenyl)(methyl)carbamate;N1-Boc-N1-methyl-1,4-benzenediamine;tert-Butyl N-(4-aminophenyl)-N-methylcarbamate;(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester;Carbamic acid, N-(4-aminophenyl)-N-methyl-, 1,1-dimethylethyl ester
- CBNumber:
- CB92728583
- Molecular Formula:
- C12H18N2O2
- Molecular Weight:
- 222.28
- MDL Number:
- MFCD10693199
- MOL File:
- 1092522-02-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2934208090 |
(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | STB52202 | tert-butyl N-(4-aminophenyl)-N-methylcarbamate | 1092522-02-5 | 2.5g | $442.5 | 2026-06-05 | Buy |
| Apolloscientific | OR346359 | (4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester 97% | 1092522-02-5 | 100mg | $28 | 2026-06-04 | Buy |
| Apolloscientific | OR346359 | (4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester 97% | 1092522-02-5 | 250mg | $39 | 2026-06-04 | Buy |
| Apolloscientific | OR346359 | (4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester 97% | 1092522-02-5 | 1g | $97 | 2026-06-04 | Buy |
| Apolloscientific | OR346359 | (4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester 97% | 1092522-02-5 | 5g | $474 | 2026-06-04 | Buy |
(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester Chemical Properties, Uses, Production
Synthesis
474020-88-7
1092522-02-5
The general procedure for the synthesis of tert-butyl (4-aminophenyl)methylcarbamate from tert-butyl methyl(4-nitrophenyl)carbamate was as follows: to a mixed solution of THF/MeOH/H2O (150 mL/40 mL/80 mL) containing methyl tert-butyl(4-nitrophenyl)carbamate (8.3 g, 32.9 mmol) was added iron powder (9.4 g), 168 mmol, and ammonium chloride (18 g, 337 mmol), in sequence. (168 mmol) and ammonium chloride (18 g, 337 mmol). The reaction mixture was heated and stirred at 50 °C for 4 h under nitrogen protection. After completion of the reaction, it was cooled to room temperature and filtered through a diatomaceous earth pad to remove solid impurities. The filtrate was extracted with ethyl acetate (100 mL x 3), and the organic phases were combined, washed sequentially with water and saturated saline, and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to afford the target product tert-butyl (4-aminophenyl)methylcarbamate (7.3 g, 100% yield) as a yellow solid. The product was analyzed by LC-MS (ESI) with m/z (M + 1) of 223.
References
[1] Patent: US2013/197014, 2013, A1. Location in patent: Paragraph 0734; 0735
[2] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 23, p. 10034 - 10042
[3] Patent: EP2409977, 2012, A1. Location in patent: Page/Page column 124
[4] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 2, p. 112 - 116
[5] Patent: , 2016, . Location in patent: Paragraph 0039; 0077; 0078; 0079
(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
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Preparation Products
(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4904 | 55 |
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| Shanghai Carlow Chemicals Co., Ltd. | 21-33526724 18930996265 | info@carlowchem.com | China | 1820 | 50 |
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| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9778 | 55 |
| Yantai ShengKailun Chemical Technology Co., Ltd. | 13356901049 | 3119594100@qq.com | China | 7964 | 55 |
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