2,4,6-Trichlorophenyl forMate
- CAS No.
- 4525-65-9
- Chemical Name:
- 2,4,6-Trichlorophenyl forMate
- Synonyms
- 2,4,6-Trichlorophenyl forMate;Phenol, 2,4,6-trichloro-, 1-formate;2,4,6-trichlorophenylmacetic acidester;Formic Acid 2,4,6-Trichlorophenyl Ester
- CBNumber:
- CB92736784
- Molecular Formula:
- C7H3Cl3O2
- Molecular Weight:
- 225.46
- MDL Number:
- MFCD27996252
- MOL File:
- 4525-65-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H314 |
| Precautionary statements | P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378-P403+P235-P405-P501 |
| HS Code | 2915.13.1000 |
2,4,6-Trichlorophenyl forMate price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T3121 | 2,4,6-Trichlorophenyl Formate >97.0%(HPLC) | 4525-65-9 | 1g | $25 | 2026-04-30 | Buy |
| TCI Chemical | T3121 | 2,4,6-Trichlorophenyl Formate >97.0%(HPLC) | 4525-65-9 | 5g | $57 | 2026-04-30 | Buy |
| Biosynth | EAA52565 | 2,4,6-Trichlorophenyl Formate | 4525-65-9 | 25g | $1112.25 | 2026-06-04 | Buy |
| Biosynth | EAA52565 | 2,4,6-Trichlorophenyl Formate | 4525-65-9 | 50g | $1547 | 2026-06-04 | Buy |
| Biosynth | EAA52565 | 2,4,6-Trichlorophenyl Formate | 4525-65-9 | 100g | $2476 | 2026-06-04 | Buy |
2,4,6-Trichlorophenyl forMate Chemical Properties, Uses, Production
Uses
2,4,6-Trichlorophenyl forMate is a highly active and readily available carbon monoxide (CO) substitute, primarily used in palladium-catalyzed carbonylation reactions, especially as an intermediate in the synthesis of chemicals such as pesticides, insecticides, and herbicides.
Synthesis
64-18-6
88-06-2
4525-65-9
1. In a dry reaction flask, formic acid (57.3 mL, 1519 mmol) and acetic anhydride (115 mL, 1216 mmol) were added, stirred and heated to 60 °C, and the reaction was maintained at this temperature for 1.5 hours. 2. Upon completion of the reaction, the reaction mixture was cooled to room temperature. 3. The cooled reaction solution was slowly poured into a flask containing 2,4,6-trichlorophenol (30 g, 152 mmol) and sodium acetate (12.46 g, 152 mmol). 4. The mixture was stirred and reacted at room temperature for 3.5 hours. 5. At the end of the reaction, the reaction mixture was diluted with toluene (300 mL) followed by washing the organic phase with deionized water (2 x 200 mL). 6. The organic phase was separated, dried over anhydrous sodium sulfate and filtered to remove the desiccant. 7. The filtrate was concentrated to dryness under reduced pressure to give white needle-like crystals of 2,4,6-trichlorophenyl formate (32.45 g). 8. The product was analyzed by liquid chromatography. 8. The product was analyzed and confirmed by liquid chromatography-mass spectrometry (LCMS) using 2 mM formic acid as the mobile phase with a retention time (Rt) of 1.15 min. The [M + Na]+ peak was observed by mass spectrometry at m/z of 249.8.
References
[1] Organic Letters, 2012, vol. 14, # 20, p. 5370 - 5373,4
[2] ChemCatChem, 2016, vol. 8, # 10, p. 1788 - 1791
[3] Recueil des Travaux Chimiques des Pays-Bas, 1965, vol. 84, p. 1247 - 1252
[4] Patent: WO2017/37116, 2017, A1. Location in patent: Page/Page column 76
[5] Patent: WO2017/50714, 2017, A1. Location in patent: Page/Page column 53
2,4,6-Trichlorophenyl forMate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Zhengzhou Alfachem Co., Ltd. | 13333829863 13333829863 | 3986163027@qq.com | China | 963 | 55 |
| Nanjing ShengSai Chemical Co., Ltd. | 025-85205967 13951876367 | shengsaichem@163.com | China | 818 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from 2,4,6-Trichlorophenyl forMate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | 246-Trichlorophenyl forMate
4525-65-9
|
$11.00-25.00 | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- 246-Trichlorophenyl forMate
4525-65-9
- $11.00-25.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
