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6-(Trifluoromethyl)pyridine-3-carboxaldehyde

6-(Trifluoromethyl)pyridine-3-carboxaldehyde structure

CAS No.: 386704-12-7

Chemical Name:: 6-(Trifluoromethyl)pyridine-3-carboxaldehyde

Synonyms: 6-(TRIFLUOROMETHYL)NICOTINALDEHYDE;5-Formyl-2-(trifluoromethyl)pyridine;6-trifluoromethyl nicotinic aldehyde;6-Trifluoromethylpyridine-3-aldehyde;6-(Trifluoromethyl)nicotinaldehyde 97%;6-(Trifluoromethyl)pyrdine-3-carbaldehyde;2-(trifluoromethyl)pyridine-5-carbaldehyde;6-(Trifluoromethyl)-pyridin-3-carbaldehyde;2-(Trifluoromethyl)pyridine-5-carboxaldehyde;6-(TrifluoroMethyl)-3-pyridinecarboxaldehyde

CBNumber:: CB9277223

Molecular Formula:: C7H4F3NO

Molecular Weight:: 175.11

MDL Number:: MFCD01862647

MOL File:: 386704-12-7.mol

MSDS File:: SDS

Last updated:2026-09-12 18:56:20

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6-(Trifluoromethyl)pyridine-3-carboxaldehyde Properties

Melting point	52-56 °C
Boiling point	72 °C
Density	1.369±0.06 g/cm3(Predicted)
Flash point	93 °C
storage temp.	2-8°C
solubility	soluble in Methanol
pka	-1.25±0.22(Predicted)
form	Solid
color	White to Almost white
Sensitive	Air Sensitive
InChI	InChI=1S/C7H4F3NO/c8-7(9,10)6-2-1-5(4-12)3-11-6/h1-4H
InChIKey	MRPAGRCGPAXOGS-UHFFFAOYSA-N
SMILES	C1=NC(C(F)(F)F)=CC=C1C=O
CAS DataBase Reference	386704-12-7(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H315-H317-H319-H335

Precautionary statements

P280-P301+P310+P330-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes

Xi,T

Risk Statements

36/37/38-43-25

Safety Statements

26-36/37/39-36/37-28

RIDADR

UN 2811 6.1/PG 3

WGK Germany

Hazard Note

Irritant

HazardClass

6.1

PackingGroup

Ⅲ

HS Code

2933399990

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
STOT SE 3

NFPA 704

	1
3		0

6-(Trifluoromethyl)pyridine-3-carboxaldehyde price More Price(61)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	640085	6-(Trifluoromethyl)pyridine-3-carboxaldehyde 95%	386704-12-7	1g	$161	2023-06-20	Buy
Sigma-Aldrich	640085	6-(Trifluoromethyl)pyridine-3-carboxaldehyde 95%	386704-12-7	5g	$699	2023-06-20	Buy
TCI Chemical	T2838	6-(Trifluoromethyl)-3-pyridinecarboxaldehyde >98.0%(GC)	386704-12-7	1g	$84	2026-04-30	Buy
TCI Chemical	T2838	6-(Trifluoromethyl)-3-pyridinecarboxaldehyde >98.0%(GC)	386704-12-7	5g	$289	2026-04-30	Buy
Apolloscientific	PC4333	6-(Trifluoromethyl)nicotinaldehyde 97%	386704-12-7	1g	$21	2026-06-04	Buy

Product number	Packaging	Price	Buy
640085	1g	$161	Buy
640085	5g	$699	Buy
T2838	1g	$84	Buy
T2838	5g	$289	Buy
PC4333	1g	$21	Buy

6-(Trifluoromethyl)pyridine-3-carboxaldehyde Chemical Properties, Uses, Production

Uses

6-(Trifluoromethyl)pyridine-3-carboxaldehyde is a reagent in the preparation of piperidine derivatives as possible Alzheimer’s treatment agents.

Synthesis

386704-04-7

386704-12-7

General procedure for the synthesis of 6-(trifluoromethyl)pyridine-3-carboxaldehyde from 6-(trifluoromethyl)-3-pyridine methanol: Intermediate 174: 6-(Trifluoromethyl)nicotine derivative; 800 mg of 6-(trifluoromethyl)pyridin-3-yl)methanol (Intermediate 173, 4.52 mmol) was dissolved in 50 mL of dichloromethane (DCM) and cooled to 0°C. To this solution was added 2 g of manganese dioxide (MnO2, 23 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the insoluble material was removed by filtration and the filtrate was concentrated at room temperature to give 750 mg (95% yield) of 6-trifluoromethylpyridine-3-carbaldehyde as a white solid. The product was characterized by 1H-NMR (CDCl3): δ 7.88-7.90 (1H, d), 8.36-8.38 (1H, d), 9.20 (1H, s), 10.22 (1H, s); TLC (DCM/MeOH 10:1) showed Rf = 0.9.

References

[1] Patent: WO2008/148853, 2008, A1. Location in patent: Page/Page column 182
[2] Patent: US2009/239905, 2009, A1. Location in patent: Page/Page column 14
[3] Patent: WO2007/110667, 2007, A1. Location in patent: Page/Page column 27

6-(Trifluoromethyl)pyridine-3-carboxaldehyde synthesis

Synthesis of 6-(Trifluoromethyl)pyridine-3-carboxaldehyde from 6-(Trifluoromethyl)pyridine-3-methanol

6-(Trifluoromethyl)pyridine-3-carboxaldehyde Preparation Products And Raw materials

Raw materials

5-Bromo-2-iodopyridine Magnesium nitrate Hexane Nitrogen N-Methyl-2-pyrrolidone

N,N-Dimethylformamide Sodium sulfate Cuprous iodide Sodium chloride Potassium fluoride

Potassium carbonate Sodium Tetrahydrofuran Iodine Ethyl acetate

Sodium bicarbonate Dichloromethane Chlorodifluoroacetic acid ethyl ester Magnesium sulfate n-Butyllithium

2-Chloropropane

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Preparation Products

6-(Trifluoromethyl)pyridine-3-carboxaldehyde Suppliers

Global Suppliers ( 208)

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Cheminspire Technology Co., Ltd.	0571-89081561; 10006559855	info@cheminspire.com	China	412	58
Taizhou Yikang Chemical Co., Ltd.	0576-88501337 18057652630	sales@yikangchemicals.com	China	272	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Carbott PharmTech Inc.	0535-6385396	info@carbottpharm.com	China	996	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64

Supplier	Advantage
Hangzhou Cheminspire Technology Co., Ltd.	58
Taizhou Yikang Chemical Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Carbott PharmTech Inc.	56
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64

View Latest Price from 6-(Trifluoromethyl)pyridine-3-carboxaldehyde manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	6-(Trifluoromethyl)nicotinaldehyde 386704-12-7	$2.20-8.80	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2026-08-20	6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE 386704-12-7	$1.10	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2025-06-06	6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE 386704-12-7	$140.00-200.00	1kg	98%	10mt	Sach biotech Co.,Ltd

6-(Trifluoromethyl)nicotinaldehyde
386704-12-7
$2.20-8.80
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE
386704-12-7
$1.10
99.00%
Dideu Industries Group Limited

6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE
386704-12-7
$140.00-200.00
98%
Sach biotech Co.,Ltd

6-(Trifluoromethyl)pyridine-3-carboxaldehyde Spectrum

6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE(386704-12-7)¹HNMR 6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE(386704-12-7)FT-IR

386704-12-7 (6-(Trifluoromethyl)pyridine-3-carboxaldehyde) Related Search:

6-(Trifluoromethyl)pyridine-3-methanol 6-(Trifluoromethyl)-1-indanone [6-(trifluoromethoxy)pyridin-2-yl]methanamine [6-(trifluoromethoxy)pyridin-3-yl]methanamine 3-Trifluoromethyl-2-formylpyridine

2-(Trifluoromethyl)-pyridine-4-carboxaldehyde 2-Chloro-5-(trifluoromethyl)-pyridine-4-carboxaldehyde 3-Chloro-5-(trifluoromethyl)pyridine-2-carboxaldehyde 2-(Trifluoromethyl)nicotinaldehyde 6-Hydroxy-5-(2-hydroxybenzoyl)-2-(trifluoromethyl)nicotinic acid

Methyl N-[5-oxo-2-(trifluoromethyl)-5H-chromeno[2,3-b]pyridin-3-yl]carbamate N,N-Dimethyl-N'-[5-oxo-2-(trifluoromethyl)-5H-chromeno[2,3-b]pyridin-3-yl]urea N-Methoxy-N-methyl-N'-[5-oxo-2-(trifluoromethyl)-5H-chromeno[2,3-b]pyridin-3-yl]urea N-(2,4-Difluorophenyl)-5-oxo-2-(trifluoromethyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide N-(4-Chlorobenzyl)-5-oxo-2-(trifluoromethyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide

N-(2,6-Dimethylphenyl)-5-oxo-2-(trifluoromethyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide 5-Oxo-2-(trifluoromethyl)-N-[3-(trifluoromethyl)benzyl]-5H-chromeno[2,3-b]pyridine-3-carboxamide N-Benzyl-5-oxo-2-(trifluoromethyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide

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6-(TrifluoroMethyl)-3-pyridinecarboxaldehyde 6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE, 6-TRIFLUOROMETHYL-PYRIDINE-3-CARBALDEHYDE 6-(Trifluoromethyl)pyridine-3-carboxaldehyde 95% 2-(Trifluoromethyl)pyridine-5-carboxaldehyde 2-(Trifluoromethyl)pyridine-5-carboxaldehyde 97% 2-(Trifluoromethyl)pyridine-5-carboxaldehyde97% 5-Formyl-2-(trifluoromethyl)pyridine, 6-(Trifluoromethyl)pyridine-3-carboxaldehyde 6-(Trifluoromethyl)nicotinaldehyde 97% 2-(Trifluoromethyl)pyridine-5-carboxaldehyde, 5-Formyl-2-(trifluoromethyl)pyridine, 6-(Trifluoromethyl)pyridin-3-carboxaldehyde 6-(Trifluoromethyl)pyrdine-3-carbaldehyde 3-Pyridinecarboxaldehyde, 6-(trifluoromethyl)- 2-Hydroxy-2',5,5'-trichlorobiphenyl@100 μg/mL in Isooctane 6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE ISO 9001：2015 REACH 6-trifluoromethyl nicotinic aldehyde 6-Trifluoromethylpyridine-3-aldehyde 2-(trifluoromethyl)pyridine-5-carbaldehyde 6-(Trifluoromethyl)-pyridin-3-carbaldehyde 5-Formyl-2-(trifluoromethyl)pyridine 6-(TRIFLUOROMETHYL)NICOTINALDEHYDE 6-(Trifluoromethyl)pyridine-3-carboxaldehyde 386704-12-7 Fluorine series Heterocyclic Compounds Aldehydes Pyridines Building Blocks Pyridine