ACEP-1
- CAS No.
- 127122-98-9
- Chemical Name:
- ACEP-1
- Synonyms
- ACEP-1;SGQSWRPQGRF-NH2;S-G-Q-S-W-R-P-Q-G-R-F, AMIDE;ACHATINA CARDIOEXCITATORY PEPTIDE-1;SER-GLY-GLN-SER-TRP-ARG-PRO-GLN-GLY-ARG-PHE-NH2;SER-GLY-GLN-SER-TRP-ARG-PRO-GLN-GLY-ARG-PHE AMIDE;ser-gly-gln-ser-trp-arg-pro-gln-gly-*arg-phe amid;H-SER-GLY-GLN-SER-TRP-ARG-PRO-GLN-GLY-ARG-PHE-NH2;Cardioexcitatory peptide 1 (Achatina fulica) (9CI)
- CBNumber:
- CB9297360
- Molecular Formula:
- C57H85N21O15
- Molecular Weight:
- 1304.42
- MDL Number:
- MFCD00080357
- MOL File:
- 127122-98-9.mol
- TDS File:
- TDS
ACEP-1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA009AVD | ACEP-1 ≥95% | 127122-98-9 | 1mg | $129 | 2026-05-28 | Buy |
| aablocks | AA009AVD | ACEP-1 ≥95% | 127122-98-9 | 5mg | $300 | 2026-05-28 | Buy |
| aablocks | AA009AVD | ACEP-1 ≥95% | 127122-98-9 | 10mg | $412 | 2026-05-28 | Buy |
| Usbiological | A0544 | Achatina Cardio-Excitatory Peptide-1 | 127122-98-9 | 1mg | $531 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0004338 | SER-GLY-GLN-SER-TRP-ARG-PRO-GLN-GLY-ARG-PHE-NH2 95.00% | 127122-98-9 | 1MG | $681.57 | 2021-12-16 | Buy |
ACEP-1 Chemical Properties, Uses, Production
Description
Achatina cardioexitatory peptide-1 (ACEP-1) is an undecapeptide identified from the African giant snail Achatina fulica. Structurally related peptides are known in a sea hare, Aplysia californica, and a freshwater snail, Lymnaea stagnalis. A G protein-coupled receptor for the ACEP-1 receptor has been identified in several animals.
Discovery
ACEP-1 was originally isolated from the peptidic extract of the atria of Achatina fulica through the combination of fractionation with reversed-phase or cation-exchange column HPLC and bioassay on the ventricle of the animal.In Aplysia, the L5-67 gene that is specifically expressed in the left upper quadrant (LUQ) neurons of the abdominal ganglia was identified to be a precursor of an ACEP-1 related peptide.The peptide was named LUQIN.In the freshwater snail L. stagnalis, the ACEP-1 related peptide, LyCEP, was purified from the ganglia of the animal as the endogenous ligand to an orphan GPCR, GRL106.
Structure
ACEP-1 is an undecapeptide while all the other related peptides are decapeptides. ACEPs identified in mollusks share the identical C-terminal WRPQGRF-NH2 structure.
Biological functions
ACEP-1 and LyCEP have cardioexcitatory action on A. fulica and L. stagnalis, respectively.A major difference in the action of the two peptides is that ACEP-1 augments the beating amplitude of the ventricle but not the auricle of Achatina while LyCEP augments the beating frequency of the auricle of Lymnaea. ACEP-1 increases the phasic contractions of the penis retractor muscle and buccal muscle that were elicited by the electrical stimulation of the muscles.It also induces the spontaneous discharge of buccal B4 neurons. ACEP-1 in the B10 neuron, together with ACh, mediates an excitatory action on the radula protractor muscle.
Uses
Cardioexcitatory peptide 1 is a cardioexcitatory neuropeptide, can be isolated from Achatina atria. Cardioexcitatory peptide 1 has potent cardio-excitatory action on the hearts and also modifies the motility of muscular tissues and neural activities[1].
References
[1] Satake H, Takuwa K, Minakata H. Characterization of cDNA and expression of mRNA encoding an Achatina cardioexcitatory RFamide peptide. Peptides. 1999 Nov;20(11):1295-302. DOI:10.1016/s0196-9781(99)00134-5
ACEP-1 Preparation Products And Raw materials
Raw materials
Preparation Products
ACEP-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 1010 | 55 |
| Nanjing Leon Biological Technology Co., Ltd. | 025-84523390 -127; 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
