A-889425
- CAS No.
- 1072921-02-8
- Chemical Name:
- A-889425
- Synonyms
- A-889425;A889425; A 889425;[1(2H),2'-Bipyridine]-4-carboxamide, 3,6-dihydro-3'-methyl-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-
- CBNumber:
- CB93038492
- Molecular Formula:
- C19H18F3N3O3S
- Molecular Weight:
- 425.43
- MDL Number:
- MFCD28160276
- MOL File:
- 1072921-02-8.mol
- MSDS File:
- SDS
A-889425 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | XSB92102 | A-889425 | 1072921-02-8 | 25mg | $1281 | 2026-06-05 | Buy |
| Biosynth | XSB92102 | A-889425 | 1072921-02-8 | 50mg | $1782.5 | 2026-06-05 | Buy |
| Biosynth | XSB92102 | A-889425 | 1072921-02-8 | 100mg | $2852 | 2026-06-05 | Buy |
| ChemScene | CS-0112827 | A-889425 | 1072921-02-8 | 5mg | $672 | 2026-06-04 | Buy |
| ChemScene | CS-0112827 | A-889425 | 1072921-02-8 | 10mg | $940 | 2026-06-04 | Buy |
A-889425 Chemical Properties, Uses, Production
Uses
A-889425 is an oral active selective TRPV1 receptor antagonist with the with an IC50 of 335 nM (rat) and 34 nM (human). A-889425 has good penetration into the CNS and reduces mechanical allodynia and spinal neuron responses to mechanical stimulation of Complete Freund's adjuvant (HY-153808)-inflamed rat hind paws[1][2].
References
[1] McGaraughty S, et al. Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats. J Neurophysiol. 2008;100(6):3158-3166. DOI:10.1152/jn.90768.2008
[2] Brederson JD, et al. TRPV1 antagonist, A-889425, inhibits mechanotransmission in a subclass of rat primary afferent neurons following peripheral inflammation. Synapse. 2012;66(3):187-195. DOI:10.1002/syn.20992
A-889425 Preparation Products And Raw materials
Raw materials
Preparation Products
A-889425 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 |
| Supplier | Advantage |
|---|---|
| AdooQ BioScience, LLC | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 58 |
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
