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ChemicalBook >> CAS DataBase List >>3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile

3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile

3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile Structure
3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile structure
CAS No.
134997-74-3
Chemical Name:
3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile
Synonyms
3-oxo-4H-1,4-benzoxazine-6-carbonitrile;3,4-Dihydro-3-oxo-2H-1,4-benzoxazine-6-carbonitrile;2H-1,4-Benzoxazine-6-carbonitrile, 3,4-dihydro-3-oxo-;3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonitrile;3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile
CBNumber:
CB93084297
Molecular Formula:
C9H6N2O2
Molecular Weight:
174.16
MDL Number:
MFCD20039908
MOL File:
134997-74-3.mol
Last updated:2026-05-28 06:28:11
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3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile Properties

Melting point 106-108 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
Boiling point 403.2±45.0 °C(Predicted)
Density 1.39±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form solid
pka 11.77±0.20(Predicted)
color Pale brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
HS Code  2933998090

3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR52436 3,4-Dihydro-3-oxo-2H-1,4-benzoxazine-6-carbonitrile 95% 134997-74-3 250mg $73 2026-06-04 Buy
Apolloscientific OR52436 3,4-Dihydro-3-oxo-2H-1,4-benzoxazine-6-carbonitrile 95% 134997-74-3 1g $184 2026-06-04 Buy
Matrix Scientific 171547 3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonitrile 134997-74-3 1.00g $99 2026-05-18 Buy
Matrix Scientific 171547 3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonitrile 134997-74-3 5.00g $392 2026-05-18 Buy
Matrix Scientific 171547 3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonitrile 134997-74-3 10.00g $685 2026-05-18 Buy
Product number Packaging Price Buy
OR52436 250mg $73 Buy
OR52436 1g $184 Buy
171547 1.00g $99 Buy
171547 5.00g $392 Buy
171547 10.00g $685 Buy

3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile Chemical Properties, Uses, Production

Synthesis

6-BROMO-2H-1,4-BENZOXAZIN-3(4H)-ONE

24036-52-0

ZINC CYANIDE

557-21-1

3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile

134997-74-3

A degassed suspension was prepared from 6-bromo-2H-1,4-benzoxazin-3(4H)-one (8.39 g), zinc cyanide (3.46 g) and tetrakis(triphenylphosphine)palladium (2.13 g) in DMF (70 mL). The suspension was reacted in an oil bath at 80 °C with stirring overnight. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into water (500 mL). The precipitate was collected by diafiltration, air dried and washed with pentane. The resulting solid was dissolved in a solvent mixture of dichloromethane/methanol (1:1), filtered through a pad of silica gel, and the filtrate was concentrated to give the yellow solid product 3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile (5.68 g, 89% yield). Mass spectrometric detection showed [MH]+ = 175.

References

[1] Patent: WO2008/63667, 2008, A1. Location in patent: Page/Page column 69
[2] Patent: WO2008/63669, 2008, A1. Location in patent: Page/Page column 72
[3] Patent: WO2008/63671, 2008, A2. Location in patent: Page/Page column 174

3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile Preparation Products And Raw materials

Raw materials

2-Amino-4-cyano-phenol 6-Bromo-2H-1,4-benzoxazin-3(4H)-one 6-Chloro-2H-1,4-benzoxazin-3(4H)-one Copper(I) Cyanide ZINC CYANIDE
Chloroacetyl chloride Bromoacetyl bromide N,N-Dimethylformamide Tetrakis(triphenylphosphine)palladium

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Preparation Products

4-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile

3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile Suppliers

Global Suppliers ( 35)
Supplier Tel Email Country ProdList Advantage
Shanghai Synthfine Chemical Co.,Ltd 15921303235 sales@synthfine.com China 995 58
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
Zhengzhou Guancheng Laboratory equipment Sales 0371-88888888 qq272369594;2159423853qq 2723695949@qq.com China 4990 50
JW & Y Pharmlab Co., Ltd. 021-64340559 xinyu_shi@jwypharmlab.com.cn China 11999 58
SuZhou ShiYa Biopharmaceuticals, Inc. 0512-0512-52358471 17715136450 sales@shiyabiopharm.com China 9814 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 9996 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Wuxi AppTec 022-59987777 13552403979 jia_guoqiang@wuxiapptec.com China 22344 58
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Supplier Advantage
Shanghai Synthfine Chemical Co.,Ltd 58
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55
Zhengzhou Guancheng Laboratory equipment Sales 50
JW & Y Pharmlab Co., Ltd. 58
SuZhou ShiYa Biopharmaceuticals, Inc. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai SuperLan Chemcial Technique Centre 58
Amadis Chemical Company Limited 58
Wuxi AppTec 58
Capot Chemical Co.,Ltd. 60

3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile Spectrum

3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile(134997-74-3)1HNMR

134997-74-3 (3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile) Related Search:

3-Oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylic acid 3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde 6-Methyl-2H-1,4-benzoxazin-3(4H)-one 2H-1,4-Benzoxazin-3(4H)-one 8-Methyl-2H-benzo[b][1,4]oxazin-3(4H)-one
6-ethynyl-2H-benzo[b][1,4]oxazin-3(4H)-one

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3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile 3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonitrile 2H-1,4-Benzoxazine-6-carbonitrile, 3,4-dihydro-3-oxo- 3-oxo-4H-1,4-benzoxazine-6-carbonitrile 3,4-Dihydro-3-oxo-2H-1,4-benzoxazine-6-carbonitrile 134997-74-3