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2H-1,4-Benzoxazin-3(4H)-one

2H-1,4-Benzoxazin-3(4H)-one Structure
2H-1,4-Benzoxazin-3(4H)-one structure
CAS No.
5466-88-6
Chemical Name:
2H-1,4-Benzoxazin-3(4H)-one
Synonyms
AURORA KA-5421;4-AZA-3-CHROMANONE;OTAVA-BB BB7020041238;1,4-Benzoxazine-3-one;BENZO[B]MORPHOLIN-3-ONE;2H-1,4-Benzoxazin-3-one;4H-1,4-benzoxazin-3-one;4H-BENZO[1,4]OXAZIN-3-ONE;3-OXO-4H-BENZO[1,4]OXAZINE;2H-1,4-Benzoxazin-3(4H)-one
CBNumber:
CB5111761
Molecular Formula:
C8H7NO2
Molecular Weight:
149.15
MDL Number:
MFCD00158536
MOL File:
5466-88-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:53:02
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2H-1,4-Benzoxazin-3(4H)-one Properties

Melting point 173-175 °C(lit.)
Boiling point 337.7±31.0 °C(Predicted)
Density 1.244±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility methanol: soluble25mg/mL, clear, colorless
pka 12.89±0.20(Predicted)
form Flakes or Powder
color White to yellow to tan
λmax 286nm(EtOH)(lit.)
InChI 1S/C8H7NO2/c10-8-5-11-7-4-2-1-3-6(7)9-8/h1-4H,5H2,(H,9,10)
InChIKey QRCGFTXRXYMJOS-UHFFFAOYSA-N
SMILES O=C1COc2ccccc2N1
CAS DataBase Reference 5466-88-6(CAS DataBase Reference)
FDA UNII Q0QAF5G662
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  DM3270000
HazardClass  IRRITANT
HS Code  29349990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2H-1,4-Benzoxazin-3(4H)-one price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 383503 2H-1,4-Benzoxazin-3(4H)-one 99% 5466-88-6 25g $70.8 2026-04-30 Buy
Sigma-Aldrich 383503 2H-1,4-Benzoxazin-3(4H)-one 99% 5466-88-6 5g $48 2023-06-20 Buy
TCI Chemical B4553 2H-1,4-Benzoxazin-3(4H)-one >98.0%(GC) 5466-88-6 5g $27 2026-04-30 Buy
TCI Chemical B4553 2H-1,4-Benzoxazin-3(4H)-one >98.0%(GC) 5466-88-6 25g $80 2026-04-30 Buy
AstaTech 64814 3-OXO-4H-BENZO[1,4]OXAZINE 97% 5466-88-6 1G $30 2026-04-30 Buy
Product number Packaging Price Buy
383503 25g $70.8 Buy
383503 5g $48 Buy
B4553 5g $27 Buy
B4553 25g $80 Buy
64814 1G $30 Buy

2H-1,4-Benzoxazin-3(4H)-one Chemical Properties,Uses,Production

Chemical Properties

white to almost white crystalline powder

Uses

2H-1,4-Benzoxazin-3-one is used to prepare benzoxazinone/benzothiazinone analogs of fluconazole with antifungal and anti-Candida activities. It is used to synthesize 1,4-benzoxazine derivatives with vasorelaxant activities.

Synthesis Reference(s)

Synthesis, p. 851, 1984 DOI: 10.1055/s-1984-30993

General Description

2H-1,4-Benzoxazin-3(4H)-one, a benzoxazine derivative, is a heterocyclic building block for various natural and synthetic organic compounds. It has been reported as an intermediate during the biogenesis of cyclic hydoxamic acids in maize. Its standard molar enthalpy of formation and tautomerization energy of its tautomers has been evaluated by calorimetric and computational methods. It has been synthesized by reacting o-aminophenol with chloroacetyl chloride in the presence of butanone and aqueous NaHCO3.

2H-1,4-Benzoxazin-3(4H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

3-Oxo-3,4-dihydro-2H-1,4-benzoxazine-6-sulfonyl chloride 2 3-Dihydro-3-oxo-4H-1 4-benzoxazine-4-& Benzomorpholine 6-Bromo-2H-1,4-benzoxazin-3(4H)-one 6-(3-phenylprop-2-enoyl)-3,4-dihydro-2H-1,4-benzoxazin-3-one
Ethyl 2-(2,3-dihydro-3-oxobenzo[b][1,4]oxazin-4-yl)acetate

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2H-1,4-Benzoxazin-3(4H)-one Suppliers

Global( 210)Suppliers
Supplier Tel Email Country ProdList Advantage
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Supplier Advantage
INTATRADE GmbH 66
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
Jia Xing Isenchem Co.,Ltd 66
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64

View Lastest Price from 2H-1,4-Benzoxazin-3(4H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2H-1,4-BENZOXAZIN-3(4H)-ONE pictures 2019-07-06 2H-1,4-BENZOXAZIN-3(4H)-ONE
5466-88-6
 $1.00 1KG 98% 1kg,5kg,100kg Career Henan Chemical Co

2H-1,4-Benzoxazin-3(4H)-one Spectrum

2H-1,4-BENZOXAZIN-3(4H)-ONE(5466-88-6)1HNMR2H-1,4-BENZOXAZIN-3(4H)-ONE(5466-88-6)FT-IR2H-1,4-BENZOXAZIN-3(4H)-ONE(5466-88-6)IR2H-1,4-BENZOXAZIN-3(4H)-ONE(5466-88-6)Raman

5466-88-6(2H-1,4-Benzoxazin-3(4H)-one)Related Search:

Lensiprazine Azasetron hydrochloride 7-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE 6-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE 4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE
2H-1,4-Benzoxazin-3(4H)-one 7-Fluoro-2H-1,4-benzoxazin-3(4H)-one 5-Hydroxy-2H-1,4-benzoxazin-3(4H)-one 7-Methoxy-1,3-benzoxazine-2,4-dione ETHYL 2-(2,3-DIHYDRO-3-OXOBENZO[B][1,4]OXAZIN-4-YL)ACETATE
6-CHLORO-2H-1,4-BENZOXAZIN-3(4H)-ONE 5-Nitro-2H-1,4-benzoxazin-3(4H)-one 8-Amino-2,4-dimethyl-2H-1,4-benzoxazin-3(4H)-one 8-Amino-2-methyl-2H-1,4-benzoxazin-3(4H)-one 8-Amino-2H-1,4-benzoxazin-3(4H)-one
4-Hydroxy-2H-1,4-benzoxazin-3(4H)-one BUTTPARK 5\07-33 Ethyl 2-(6-chloro-2,3-dihydro-3-oxobenzo[b][1,4]oxazin-4-yl)acetate

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4H-BENZO[1,4]OXAZIN-3-ONE 4-AZA-3-CHROMANONE 2H-1,4-BENZOXAZINE-3(4H)-ONE 2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE OTAVA-BB BB7020041238 BENZO[B]MORPHOLIN-3-ONE AURORA KA-5421 JRH-03201, 2H-Benzo[b][1,4]oxazin-3(4H)-one, 97% 2H-1,4-Benzooxazin-3(4H)-one 3-OXO-4H-BENZO[1,4]OXAZINE 2H-1,4-Benzoxazin-3(4H)-one, (4-Aza-3-chromanone) 2,4-Dihydro-3H-1,4-benzoxazine-3-one 3,4-Dihydro-2H-1,4-benzoxazine-3-one 2H-1,4-Benzoxazin-3(4H)-one,99% 2H-1,4-BENZOXAZIN-3(4H)-ONE 99% 3,4-Dihydro-2H-1,4-benzoxazin-3-one 3,4-dihydro-2H-1,4-benzoxazin-3(4H)-one 2H-1,4-Benzoxazin-3(4H)-one (8CI)(9CI) 2H-1,4-Benzoxazin-3-one 4H-1,4-benzoxazin-3-one 2H-1,4-Benzoxazin-3(4H)-one 1,4-Benzoxazine-3-one 2H-1,4-Benzoxazin-3(4H)-one > 5466-88-6 2H-1,4-BENZOXAZIN-3(4H)-ONE 2H-1,4-Benzoxazin-3(4H)-one (6CI, 7CI, 8CI, 9CI, ACI) 2H-1,4- 6-Benzoxazin-3(4H)-one 2H-1,4-Benzoxazin-3(4H)-one, 95% 2H-1,4-benzenebenzoazine-3(4H)-one 2H-1,4-Benzoxazin-3(4H)-one 5466-88-6 Heterocyclic Building Blocks Building Blocks Benzoxazines pharmacetical API intermediates Miscellaneous Benzoxazines Building Blocks Heterocyclic Building Blocks