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4-Bromo-1-phenyl-1H-pyrazole

4-Bromo-1-phenyl-1H-pyrazole Structure
4-Bromo-1-phenyl-1H-pyrazole structure
CAS No.
15115-52-3
Chemical Name:
4-Bromo-1-phenyl-1H-pyrazole
Synonyms
4-bromo-1-phenylpyrazole;4-Bromo-1-phenyl-1H-pyrazole;1H-Pyrazole, 4-bromo-1-phenyl-;4-Bromo-1-phenyl-1H-pyrazole 98%
CBNumber:
CB9315598
Molecular Formula:
C9H7BrN2
Molecular Weight:
223.07
MDL Number:
MFCD00234505
MOL File:
15115-52-3.mol
MSDS File:
SDS
Last updated:2026-09-12 18:56:22
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4-Bromo-1-phenyl-1H-pyrazole Properties

Melting point 78-79 °C
Boiling point 296.2±13.0 °C(Predicted)
Density 1.50±0.1 g/cm3(Predicted)
storage temp. 2-8°C
form solid
pka -1.34±0.10(Predicted)
color Brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P271-P261-P280
Hazard Codes  Xi
HazardClass  IRRITANT
HS Code  2933199090

4-Bromo-1-phenyl-1H-pyrazole price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FB139496 4-Bromo-1-phenyl-1H-pyrazole 15115-52-3 5g $900 2026-06-04 Buy
Biosynth FB139496 4-Bromo-1-phenyl-1H-pyrazole 15115-52-3 2g $900 2026-06-04 Buy
Biosynth FB139496 4-Bromo-1-phenyl-1H-pyrazole 15115-52-3 1g $900 2026-06-04 Buy
Biosynth FB139496 4-Bromo-1-phenyl-1H-pyrazole 15115-52-3 10g $900 2026-06-04 Buy
Biosynth FB139496 4-Bromo-1-phenyl-1H-pyrazole 15115-52-3 0.5g $900 2026-06-04 Buy
Product number Packaging Price Buy
FB139496 5g $900 Buy
FB139496 2g $900 Buy
FB139496 1g $900 Buy
FB139496 10g $900 Buy
FB139496 0.5g $900 Buy

4-Bromo-1-phenyl-1H-pyrazole Chemical Properties, Uses, Production

Uses

4-Bromo-1-phenylpyrazole is used to prepare canagliflozin aryl C-glucoside with thiophene ring as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus.

Synthesis

1-PHENYLPYRAZOLE

1126-00-7

4-BROMO-1-PHENYL-1H-PYRAZOLE

15115-52-3

Example 29A Synthesis of 4-bromo-1-phenyl-1H-pyrazole: 1-phenylpyrazole (Aldrich, 1 g, 6.94 mmol) was dissolved in 10 mL of acetic acid, followed by the addition of 1.1 g of bromine (Fisher, 6.94 mmol) to a 10 mL solution of acetic acid. The reaction mixture was transferred to a pressure tube and the reaction was heated at 100 °C for 8 hours. After the reaction was completed, it was cooled to room temperature and the reaction solution was slowly poured into a 500 mL beaker containing ice and water and saturated aqueous NaHCO3 solution was added dropwise until the acetic acid was completely neutralized. The organic layer was separated by adding 50 mL of ethyl acetate (EtOAc) for extraction. The aqueous layer was then extracted with 2 x 15 mL of ethyl acetate, the organic phases were combined and dried with anhydrous Na2SO4. The organic phase was concentrated under reduced pressure to obtain the crude product. Purification by fast column chromatography (silica gel, 5:0 to 5:5 gradient elution of hexane-ethyl acetate) afforded 1.5 g of the target compound 4-bromo-1-phenyl-1H-pyrazole (6.72 mmol, 97% yield). Mass spectrum (DCI/NH3) m/z 223,225 (M+H)+.

References

[1] Chemistry - A European Journal, 2015, vol. 21, # 34, p. 11976 - 11979
[2] Patent: US2005/65178, 2005, A1. Location in patent: Page/Page column 31
[3] Patent: US2005/101602, 2005, A1. Location in patent: Page/Page column 68
[4] RSC Advances, 2016, vol. 6, # 93, p. 90031 - 90034
[5] Tetrahedron Letters, 2007, vol. 48, # 26, p. 4595 - 4599

4-Bromo-1-phenyl-1H-pyrazole Preparation Products And Raw materials

Raw materials

1-Phenylpyrazole Ethyl acetate Acetic acid Sodium bicarbonate

Preparation Products

4-Bromo-1-phenyl-1H-pyrazole Suppliers

Global Suppliers ( 122)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
China Langchem Inc. 021-58956006,021-58950017 15800617331 sales@langchem.com China 209 57
Acorn PharmaTech Co., Ltd. 025-58395930 sales@acornpharma.com China 982 60
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
Pure Chemistry Scientific Inc. 62
Adamas Reagent, Ltd. 59
Shanghai Longsheng chemical Co.,Ltd. 59
China Langchem Inc. 57
Acorn PharmaTech Co., Ltd. 60

View Latest Price from 4-Bromo-1-phenyl-1H-pyrazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-BROMO-1-PHENYL-1H-PYRAZOLE pictures 2020-01-01 4-BROMO-1-PHENYL-1H-PYRAZOLE
15115-52-3
 $1.00 1KG 99% 200kg Career Henan Chemical Co

4-Bromo-1-phenyl-1H-pyrazole Spectrum

4-BROMO-1-PHENYL-1H-PYRAZOLE(15115-52-3)1HNMR4-BROMO-1-PHENYL-1H-PYRAZOLE(15115-52-3)FT-IR

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