Boc-aminooxy-PEG4-Propargyl
- CAS No.
- 1895922-77-6
- Chemical Name:
- Boc-aminooxy-PEG4-Propargyl
- Synonyms
- Boc-aminooxy-PEG4-Propargyl;t-Boc-aminooxy-PEG4-propargyl;N-Boc-O-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)hydroxylamine;1,1-Dimethylethyl 3,6,9,12,15-pentaoxa-2-azaoctadec-17-ynoate;3,6,9,12,15-Pentaoxa-2-azaoctadec-17-ynoic acid, 1,1-dimethylethyl ester
- CBNumber:
- CB93162908
- Molecular Formula:
- C16H29NO7
- Molecular Weight:
- 347.4
- MDL Number:
- MFCD29764340
- MOL File:
- 1895922-77-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
Boc-aminooxy-PEG4-Propargyl price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| BroadPharm | bp-23142 | t-Boc-aminooxy-PEG4-propargyl 98% | 1895922-77-6 | 100MG | $280 | 2026-05-24 | Buy |
| BroadPharm | bp-23142 | t-Boc-aminooxy-PEG4-propargyl 98% | 1895922-77-6 | 250MG | $460 | 2026-05-24 | Buy |
| BroadPharm | bp-23142 | t-Boc-aminooxy-PEG4-propargyl 98% | 1895922-77-6 | 500MG | $680 | 2026-05-24 | Buy |
| BroadPharm | bp-23142 | t-Boc-aminooxy-PEG4-propargyl 98% | 1895922-77-6 | 1G | $1100 | 2026-05-24 | Buy |
| aablocks | AA019E29 | 1,1-Dimethylethyl 3,6,9,12,15-pentaoxa-2-azaoctadec-17-ynoate ≥98% | 1895922-77-6 | 100mg | $1177 | 2026-05-29 | Buy |
Boc-aminooxy-PEG4-Propargyl Chemical Properties, Uses, Production
Description
t-Boc-aminooxy-PEG4-propargyl is a click chemistry tool containing a propargyl group and t-Boc-aminooxy group. Propargyl group is reactive with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to yield a stable triazole linkage. T-Boc-aminooxy can be deprotected under mild acidic conditions and then can react with an aldehyde or ketone group to form a linkage. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
Boc-aminooxy-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-aminooxy-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651
Boc-aminooxy-PEG4-Propargyl Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80534353 19917294565 | et@chemextension.com | China | 3904 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6347 | 58 | |
| Alpha Biopharmaceuticals Co., Ltd | 0411-39042497 | sales@alphabiopharm.com | China | 1951 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19904 | 58 |
| Shaanxi Xinyan Bomei Biotechnology Co., Ltd. | 13892832556 | 2440688701@qq.com | China | 1977 | 58 |
| Zhengzhou Akem Chemical Co., Ltd | 13303867194 | 770406999@qq.com | China | 9949 | 58 |
| Affinity（Wuhan）Ltd. | 15841022315 | sales@affinitytech.cn | China | 2980 | 58 |
| Aikon International Limited | 17714375163 | hywu@aikonchem.com | China | 9974 | 58 |
