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| | Boc-aminooxy-PEG4-Propargyl Basic information |
| Product Name: | Boc-aminooxy-PEG4-Propargyl | | Synonyms: | Boc-aminooxy-PEG4-Propargyl;t-Boc-aminooxy-PEG4-propargyl;3,6,9,12,15-Pentaoxa-2-azaoctadec-17-ynoic acid, 1,1-dimethylethyl ester;N-Boc-O-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)hydroxylamine;1,1-Dimethylethyl 3,6,9,12,15-pentaoxa-2-azaoctadec-17-ynoate | | CAS: | 1895922-77-6 | | MF: | C16H29NO7 | | MW: | 347.4 | | EINECS: | | | Product Categories: | | | Mol File: | 1895922-77-6.mol |  |
| | Boc-aminooxy-PEG4-Propargyl Chemical Properties |
| density | 1.083±0.06 g/cm3(Predicted) |
| | Boc-aminooxy-PEG4-Propargyl Usage And Synthesis |
| Description | t-Boc-aminooxy-PEG4-propargyl is a click chemistry tool containing a propargyl group and t-Boc-aminooxy group. Propargyl group is reactive with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to yield a stable triazole linkage. T-Boc-aminooxy can be deprotected under mild acidic conditions and then can react with an aldehyde or ketone group to form a linkage. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | Boc-aminooxy-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-aminooxy-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651 |
| | Boc-aminooxy-PEG4-Propargyl Preparation Products And Raw materials |
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