CEP-40783
- CAS No.
- 1437321-24-8
- Chemical Name:
- CEP-40783
- Synonyms
- RXDX-106;CS-2528;CEP-40783;CEP-40783(RXDX-106);RXDX-106(CEP-40783);CEP-40783(RXDX-106), 98%min;CEP 40783; CEP40783; RXDX-106;N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide;3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid [4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]amide;5-Pyrimidinecarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-
- CBNumber:
- CB93167640
- Molecular Formula:
- C31H26F2N4O6
- Molecular Weight:
- 588.56
- MDL Number:
- MFCD28502441
- MOL File:
- 1437321-24-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.394±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility |
DMF:20.0(Max Conc. mg/mL);33.89(Max Conc. mM) DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.51(Max Conc. mM) DMSO:6.04(Max Conc. mg/mL);10.26(Max Conc. mM) Ethanol:2.0(Max Conc. mg/mL);3.4(Max Conc. mM) |
| form | A crystalline solid |
| pka | 10.42±0.70(Predicted) |
| color | White to off-white |
| InChIKey | FKCWHHYUMFGOPY-UHFFFAOYSA-N |
| SMILES | C1(=O)N(C(C)C)C=C(C(NC2=CC=C(OC3C4C(N=CC=3)=CC(OC)=C(OC)C=4)C(F)=C2)=O)C(=O)N1C1=CC=C(F)C=C1 |
| FDA UNII | 1969ZJE05Q |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| NFPA 704 |
|
CEP-40783 price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25749 | CEP-40783 ≥98% | 1437321-24-8 | 1mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 25749 | CEP-40783 ≥98% | 1437321-24-8 | 5mg | $178 | 2026-04-30 | Buy |
| Cayman Chemical | 25749 | CEP-40783 ≥98% | 1437321-24-8 | 10mg | $312 | 2026-04-30 | Buy |
| Cayman Chemical | 25749 | CEP-40783 ≥98% | 1437321-24-8 | 25mg | $680 | 2026-04-30 | Buy |
| Biosynth | MHC32124 | CEP-40783 | 1437321-24-8 | 50mg | $903.5 | 2026-06-04 | Buy |
CEP-40783 Chemical Properties, Uses, Production
Uses
CEP-40783 is a potent, selective and orally potent inhibitor of axl and c-Met with IC50 values of 7nM and 12nM, respectively.
Biological Activity
RXDX-106 (CEP-40783) is an orally available, potent, and selective inhibitor of TAM (TYRO3, AXL, MER)/Met (c-Met), with low levels in peptide phosphorylation assays. Nanomolar biochemical activity; slow dissociation rate (T1/2 >120 min) in in vitro kinase binding assays.
in vitro
CEP-40783 inhibited TAM and c-MET phosphorylation, accompanied by a decrease in downstream MAPK and PI3K signaling and cellular activity. In TAM-expressing cells, sub-nanomolar concentrations of RXDX-106 completely inhibited cell proliferation and cell viability.
in vivo
CEP-40783 inhibits tumors with activating TAM gene fusions and affects the TAM-expressing tumor microenvironment, resulting in an overall anticancer environment.
target
| Target | Value | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Axl (Cell-free assay) | 7 nM | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| c-Met (Cell-free assay) | 12 nM | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tyro3 (Cell-free assay) | 19 nM | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| MER (Cell-free assay) | 29 nM | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tyro3 (Cell-free assay) | 29 nM |
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-13601744364 13601744364 | chemsharker@126.com | China | 1161 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 989 | 55 |
| INTERCHEMIE NANJING PHARMATECH CO., LTD | 13656237714 13656237714; | xiaokunfu@kyyykj.com | China | 297 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9711 | 58 |
