3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL
- CAS No.
- 57717-80-3
- Chemical Name:
- 3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL
- Synonyms
- CGP 7930;CGP 7930, Positive allosteric modulator of GABAB receptors;3-(3',5'-DI-TERT-BUTYL-4'-HYDROXY)PHENYL-2,2-DIMETHYLPROPANOL;3,5-bis(1,1-Dimethylethyl)-4-hydroxy-β,β-dimethyl-benzenepropanol;3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL;Benzenepropanol, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-β,β-dimethyl-;3,5-Bis(1,1-dimethylethyl)-4-hydroxy-beta,beta-dimethylbenzenepropanol
- CBNumber:
- CB9331718
- Molecular Formula:
- C19H32O2
- Molecular Weight:
- 292.46
- MDL Number:
- MFCD04040028
- MOL File:
- 57717-80-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| CGP 7930 | 5.05894 | 10mg | $165 |
| CGP 7930 ≥98% | 29429 | 1mg | $49 |
| CGP 7930 ≥98% | 29429 | 5mg | $143 |
| CGP 7930 ≥98% | 29429 | 10mg | $190 |
| CGP 7930 Asreported | 254943 | 10mg | $403 |
| storage temp. | Desiccate at RT |
|---|---|
| solubility | DMSO: 22 mg/mL, soluble |
| form | solid |
| color | white |
| InChI | 1S/C19H32O2/c1-17(2,3)14-9-13(11-19(7,8)12-20)10-15(16(14)21)18(4,5)6/h9-10,20-21H,11-12H2,1-8H3 |
| InChIKey | XLWJPQQFJNGUPA-UHFFFAOYSA-N |
| SMILES | OCC(Cc1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C)(C)C |
| FDA UNII | ZAM4WWA5Y4 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.05894 | CGP 7930 | 57717-80-3 | 10mg | $165 | 2026-04-30 | Buy |
| Cayman Chemical | 29429 | CGP 7930 ≥98% | 57717-80-3 | 1mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 29429 | CGP 7930 ≥98% | 57717-80-3 | 5mg | $143 | 2026-04-30 | Buy |
| Cayman Chemical | 29429 | CGP 7930 ≥98% | 57717-80-3 | 10mg | $190 | 2026-04-30 | Buy |
| Usbiological | 254943 | CGP 7930 Asreported | 57717-80-3 | 10mg | $403 | 2026-06-03 | Buy |
3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL Chemical Properties,Uses,Production
Description
CGP 7930 is a positive allosteric modulator of GABAB receptors. It enhances GABA binding with a maximal effect of 143% compared to a GABA-only control in CHO cells membranes expressing the GABAB(1b/2) receptor and enhances GABA binding to rat cortical membranes when used at a concentration of 30 μM. It is selective for GABA binding to heterodimeric GABAB(1b/2) over monomeric GABAB(1b) receptors. CGP 7930 potentiates the efficacy of the GABAB receptor agonist baclofen in decreasing the spontaneous firing rate of dopaminergic neurons in the rat ventral tegmental area (VTA) in vitro (EC50 = 0.27 μM). It also potentiates the sedative-reducing effects induced by the GABAB receptor agonists baclofen and γ-hydroxybutyric acid (GHB) in rats when administered at doses ranging from 10 to 170 mg/kg, effects that can be blocked by the GABAB receptor antagonist SCH 50911. CGP 7930 reduces self-administration of nicotine, alcohol, and cocaine in rodent models. It suppresses the acquisition of alcohol drinking behavior in alcohol-naïve Sardinian alcohol-preferring rats over a five-day period when administered at doses ranging from 25 to 100 mg/kg and transiently reduces the maintenance of alcohol drinking behavior in alcohol-experienced rats at a dose of 100 mg/kg.
Definition
ChEBI: 2,6-ditert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol is an alkylbenzene.
Biological Activity
Positive allosteric modulator of GABA B receptors. Increases the potency and efficacy of GABA at both native and recombinant GABA B receptors (EC 50 values are 5.37 and 4.60 μ M respectively) and enhances the inhibitory effect of the agonist L-baclofen in cultured cortical neurons. Reduces operant self-administration of ethanol in alcohol-preferring rats following i.p. administration.
storage
Desiccate at RT
References
[1] S. URWYLER. Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501.[J]. Molecular Pharmacology, 2001, 60 5 1: 963-971. DOI: 10.1124/mol.60.5.963
[2] YING CHEN. GABAB receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area[J]. British Journal of Pharmacology, 2009, 144 7: 926-932. DOI: 10.1038/sj.bjp.0706100
[3] MAURO A.M. CARAI . In vivo effectiveness of CGP7930, a positive allosteric modulator of the GABAB receptor[J]. European journal of pharmacology, 2004, 504 3: Pages 213-216. DOI: 10.1016/j.ejphar.2004.10.008
[4] C. L. ADAMS A. J L. CGP7930: A Positive Allosteric Modulator of the GABAB Receptor[J]. CNS drug reviews, 2007, 13 3: 308-316. DOI: 10.1111/j.1527-3458.2007.00021.x
[5] ALESSANDRO ORRù . Reducing effect of the positive allosteric modulators of the GABAB receptor, CGP7930 and GS39783, on alcohol intake in alcohol-preferring rats[J]. European journal of pharmacology, 2005, 525 1: Pages 105-111. DOI: 10.1016/j.ejphar.2005.10.005
3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL Preparation Products And Raw materials
Raw materials
Preparation Products
3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27066 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25020 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
