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ChemicalBook >> CAS DataBase List >>5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride

5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride

5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride Structure
5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride structure
CAS No.
146709-78-6
Chemical Name:
5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride
Synonyms
ZD7155HCl;ZD 7155 HYDROCHLORIDE;ZD7155 hydrochloride >=97% (HPLC);ZD 7155 hydrochloride, 10 mM in DMSO;5,7-Diethyl-3,4-dihydro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-onehydrochloride;5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride;1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-5,7-diethyl-3,4-dihydro-1,6-naphthyridin-2(1H)-one hydrochloride;1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-5,7-diethyl-3,4-dihydro-1,6-naphthyridin-2(1H)-one hydrochloride
CBNumber:
CB9360710
Molecular Formula:
C26H26N6O.ClH
Molecular Weight:
474.99
MDL Number:
MFCD00921888
MOL File:
146709-78-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:56:26
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5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride Properties

storage temp. Inert atmosphere,2-8°C
solubility DMSO: 10 mM
form Powder
color White to yellow
Water Solubility Soluble to 10 mM in water with gentle warming
InChIKey NAGGAAHTUXEGFG-UHFFFAOYSA-N
SMILES CCC1=C(C2=CC(CC)=N1)CCC(N2CC3=CC=C(C=C3)C4=C(C=CC=C4)C5=NN=NN5)=O.Cl
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2114 ZD7155 hydrochloride ≥97% (HPLC) 146709-78-6 5 mg $98.4 2026-04-30 Buy
Sigma-Aldrich SML2114 ZD7155 hydrochloride ≥97% (HPLC) 146709-78-6 25 mg $268.6 2026-04-30 Buy
Cayman Chemical 36576 ZD 7155 (hydrochloride) ≥98% 146709-78-6 1mg $32 2026-04-30 Buy
Cayman Chemical 36576 ZD 7155 (hydrochloride) ≥98% 146709-78-6 5mg $109 2026-04-30 Buy
Cayman Chemical 36576 ZD 7155 (hydrochloride) ≥98% 146709-78-6 10mg $203 2026-04-30 Buy
Product number Packaging Price Buy
SML2114 5 mg $98.4 Buy
SML2114 25 mg $268.6 Buy
36576 1mg $32 Buy
36576 5mg $109 Buy
36576 10mg $203 Buy

5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride Chemical Properties, Uses, Production

Uses

ZD 7155 Hydrochloride, is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. it is shown to be more active than the prototype AT1 antagonist, losartan, and it’s orally active.

Biological Activity

A potent and selective competitive antagonist for the angiotensin II type 1 (AT 1 ) receptor. Displaces [ 125 I]-angiotensin II binding with an IC 50 value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT 1 antagonist, losartan.

in vivo

In conscious SD rats, ZD 7155 and losartan behave as competitive antagonists and the pressor response curve to angiotensin II is shifted to the right. Experiments in conscious SD rats also show that ZD 7155 is approximately ten times as potent as losartan in suppressing the angiotensin II-induced pressor response (240 ng/kg; 10 min infusion). In addition, experiments with conscious rats demonstrate that ZD 7155 could suppress the angiotensin II-induced pressor response for approximately 24 h when ZD 7155 is administered intravenously in a 1.082 μmol/kg bolus dose and angiotensin II is given at 240 ng/kg (in a 10-min infusion). Experiments in conscious SHRs using ZD 7155 (1.082 mumol/kg) and losartan (6.495 mumol/kg) as intravenous boluses indicate that both ZD 7155 and the reference compound losartan exhibit a significant antihypertensive effect[1].

IC 50

AT1 Receptor

storage

Desiccate at +4°C

5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride Suppliers

Global Suppliers ( 57)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2968 58
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
Aikon International Limited 025-58851090 13913916777 sales01@aikonchem.com China 15947 58
Jinan Yaoyan Pharmaceutical Co., Ltd. jnyaoyan@163.com China 3057 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Shanghai Lollane Biological Technology Co.,Ltd. 55
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Rechem science Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
Aikon International Limited 58
Jinan Yaoyan Pharmaceutical Co., Ltd. 58
Fan De(Beijing) Biotechnology Co., Ltd. 58

View Latest Price from 5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ZD 7155 hydrochloride pictures 2026-09-10 ZD 7155 hydrochloride
146709-78-6
 $35.00-137.00 99.80% 10g TargetMol Chemicals Inc.
ZD 7155 hydrochloride pictures 2026-07-15 ZD 7155 hydrochloride
146709-78-6
 $35.00-137.00 99.80% 10g TargetMol Chemicals Inc.

5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride Spectrum

5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE(146709-78-6)1HNMR

146709-78-6 (5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride) Related Search:

ZD 7155 ICI D7114 Acetamide,N-(2-methyl-4-pyridinyl)- 4-Pyridinamine, 5-ethyl-2-methyl- 3,4-Dihydro-1,6-naphthyridin-2(1H)-one
5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride C-Biphenyl-4-yl-methylamine hydrochloride 1,2,3,4-Tetrahydro-1,6-naphthyridine 1-Methyl-1,2,3,4-tetrahydro-[1,6]naphthyridine 2,6-Dimethyl-pyridin-4-ylamine

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ZD 7155 HYDROCHLORIDE 5,7-Diethyl-3,4-dihydro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-onehydrochloride ZD7155HCl ZD7155 hydrochloride >=97% (HPLC) 1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-5,7-diethyl-3,4-dihydro-1,6-naphthyridin-2(1H)-one hydrochloride ZD 7155 hydrochloride, 10 mM in DMSO 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-5,7-diethyl-3,4-dihydro-1,6-naphthyridin-2(1H)-one hydrochloride 5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride 146709-78-6 C26H27ClN6O C26H26N6OHCl