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ChemicalBook >> CAS DataBase List >>1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid

1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid

1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid Structure
1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid structure
CAS No.
126501-70-0
Chemical Name:
1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid
Synonyms
Albb-003872;N-TRIFLUOROACETYL ISONIPECOTIC ACID;1-(trifluoroacetyl)piperidine-4-carboxylic acid;1-(trifluoroacetyl)-4-piperidinecarboxylic acid;1-(2,2,2-Trifluoroacetyl)piperidine-4-carboxylic acid;1-(2,2,2-Trifluoro-acetyl)piperidin-4-carboxylic acid;1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid;4-Piperidinecarboxylic acid, 1-(2,2,2-trifluoroacetyl)-;1-(trifluoroacetyl)-4-piperidinecarboxylic acid(SALTDATA: FREE)
CBNumber:
CB9373370
Molecular Formula:
C8H10F3NO3
Molecular Weight:
225.17
MDL Number:
MFCD03840837
MOL File:
126501-70-0.mol
MSDS File:
SDS
Last updated:2026-09-12 18:56:27
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1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid Properties

Melting point 117 °C(Solv: hexane (110-54-3); ethyl ether (60-29-7))
Boiling point 386.6±42.0 °C(Predicted)
Density 1.430±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 4.27±0.20(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  T
Risk Statements  25
Safety Statements  45
HazardClass  IRRITANT
HS Code  2933399990

1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC430312 1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid 95% 126501-70-0 1g $102 2026-06-04 Buy
Matrix Scientific 035919 1-(Trifluoroacetyl)piperidine-4-carboxylic acid 126501-70-0 500.00mg $87 2026-05-18 Buy
Synthonix T0742 1-(2,2,2-Trifluoroacetyl)piperidine-4-carboxylic acid 95+% 126501-70-0 100mg $44 2026-05-06 Buy
Synthonix T0742 1-(2,2,2-Trifluoroacetyl)piperidine-4-carboxylic acid 95+% 126501-70-0 250mg $48 2026-05-06 Buy
Synthonix T0742 1-(2,2,2-Trifluoroacetyl)piperidine-4-carboxylic acid 95+% 126501-70-0 1g $50 2026-05-06 Buy
Product number Packaging Price Buy
PC430312 1g $102 Buy
035919 500.00mg $87 Buy
T0742 100mg $44 Buy
T0742 250mg $48 Buy
T0742 1g $50 Buy

1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid Chemical Properties, Uses, Production

Synthesis

Isonipecotic acid

498-94-2

Trifluoromethanesulfonic anhydride

358-23-6

1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID

126501-70-0

Example 17A1 Synthesis of 1-(2,2,2-trifluoroacetyl)piperidine-4-carboxylic acid: to a solution of piperidine-4-carboxylic acid (4 g, 30.97 mmol) in dichloromethane (20 mL) was added slowly and dropwise to trifluoromethanesulfonic anhydride (7.8 g) at 0 °C. The reaction mixture was stirred at 0 °C overnight. After completion of the reaction, the reaction solution was diluted with water, the organic layer was separated and concentrated. The crude product was purified by silica gel column chromatography to afford the title compound in 70% yield as a white solid.

References

[1] Patent: WO2013/10453, 2013, A1. Location in patent: Page/Page column 109

1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid Preparation Products And Raw materials

Raw materials

Isonipecotic acid Trifluoromethanesulfonic anhydride

Preparation Products

1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid Suppliers

Global Suppliers ( 40)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
SynAsst Chemical. 021-60343070 China 12731 55
Shanghai AQBioPharma Co., Ltd. 13661411401 yinglv.que@aqbiopharma.com.cn China 2976 58
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9781 50
Shanghai Tombiopharma Chemical Co. Ltd. 13391076197 tombiopharma@163.com China 4986 55
SPIRO PHARMA eric_feng1954@126.com China 9239 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Aikon International Limited 025-66113011 19370895928 qzhang@aikonchem.com China 15390 58
3A Chemicals 400-668-9898 service@3achem.com China 20535 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
SynAsst Chemical. 55
Shanghai AQBioPharma Co., Ltd. 58
Shanghai HuanChuan Industry Co.,Ltd. 50
Shanghai Tombiopharma Chemical Co. Ltd. 55
SPIRO PHARMA 55
Amadis Chemical Company Limited 58
Aikon International Limited 58
3A Chemicals 58

1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid Spectrum

1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID(126501-70-0)1HNMR

126501-70-0 (1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid) Related Search:

4-Piperidinemethanol, 1-(2-fluoroethyl) 4-(Trifluoroacetylamino)-1-butanol 1-Trifluoroacetyl piperidine 1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid N,N-Diethyl-2,2,2-trifluoroacetamide
1-(Trifluoroacetyl)-2-piperidinecarboxylic acid butyl ester 1-(Trifluoroacetyl)-2-piperidinecarboxylic acid 1-methylpropyl ester 1-(Trifluoroacetyl)-4-piperidinecarboxylic acid (S)-1-methylpropyl ester Piperidine, 1-(fluoroacetyl)- (6CI,7CI,8CI,9CI)

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1-(trifluoroacetyl)piperidine-4-carboxylic acid Albb-003872 1-(trifluoroacetyl)-4-piperidinecarboxylic acid(SALTDATA: FREE) 1-(2,2,2-Trifluoro-acetyl)piperidin-4-carboxylic acid 1-(2,2,2-Trifluoroacetyl)piperidine-4-carboxylic acid 1-(trifluoroacetyl)-4-piperidinecarboxylic acid N-TRIFLUOROACETYL ISONIPECOTIC ACID 4-Piperidinecarboxylic acid, 1-(2,2,2-trifluoroacetyl)- 1-(2,2,2-Trifluoroacetyl)-4-piperidinecarboxylic acid 126501-70-0