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SUC-ALA-ALA-PRO-PHE-PNA

SUC-ALA-ALA-PRO-PHE-PNA structure

CAS No.: 70967-97-4

Chemical Name:: SUC-ALA-ALA-PRO-PHE-PNA

Synonyms: SAAPNA;SUC-AAPF-PNA;Cathepsin G substrate;70967-97-4/107409-54-1;SUC-ALA-ALA-PRO-PHE-PNA;Cathepsin G Substrate I;N-SUCCINYL-ALA-ALA-PRO-PHE-PNA;SUC-ALA-ALA-PRO-PHE-PNA USP/EP/BP;SUC-ALA-ALA-PRO-PHE-PARANITROANILIDE;CATHEPSIN G SUBSTRATE I, COLORIMETRIC

CBNumber:: CB9399626

Molecular Formula:: C30H36N6O9

Molecular Weight:: 624.64

MDL Number:: MFCD00077161

MOL File:: 70967-97-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:27

Product description	Number	Pack Size	Price
N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide	S7388	25mg	$107
N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide	573462	25mg	$91.2
Suc-AAPF-pNA ≥95%	14993	10mg	$50
Suc-AAPF-pNA ≥95%	14993	25mg	$86
Suc-AAPF-pNA ≥95%	14993	100mg	$291

Request For Quotation

SUC-ALA-ALA-PRO-PHE-PNA Properties

Boiling point	1072.763±65.00 °C(Press: 760.00 Torr)(predicted)
Density	1.366±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp.	-20°C
solubility	DMF: 25 mg/mL, clear, light yellow
pka	4.691±0.10(predicted)
form	White to off-white solid
color	White to off-white
BRN	4289896
Sequence	{Suc}-Ala-Ala-Pro-Phe-{pNA}
InChIKey	LKDMKWNDBAVNQZ-UHYNAWRVNA-N
SMILES	N1(CCC[C@H]1C(=O)N[C@H](C(=O)NC1=CC=C([N+]([O-])=O)C=C1)CC1=CC=CC=C1)C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CCC(=O)O \|&1:4,8,30,35,r\|
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Precautionary statements	P271-P261-P280
PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	22-24/25
WGK Germany	3
F	10
HS Code	2933998090
Storage Class	11 - Combustible Solids

SUC-ALA-ALA-PRO-PHE-PNA price More Price(54)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S7388	N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide	70967-97-4	25mg	$107	2026-04-30	Buy
Sigma-Aldrich	573462	N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide	70967-97-4	25mg	$91.2	2026-04-30	Buy
Cayman Chemical	14993	Suc-AAPF-pNA ≥95%	70967-97-4	10mg	$50	2026-04-30	Buy
Cayman Chemical	14993	Suc-AAPF-pNA ≥95%	70967-97-4	25mg	$86	2026-04-30	Buy
Cayman Chemical	14993	Suc-AAPF-pNA ≥95%	70967-97-4	100mg	$291	2026-04-30	Buy

Product number	Packaging	Price	Buy
S7388	25mg	$107	Buy
573462	25mg	$91.2	Buy
14993	10mg	$50	Buy
14993	25mg	$86	Buy
14993	100mg	$291	Buy

SUC-ALA-ALA-PRO-PHE-PNA Chemical Properties,Uses,Production

Description

Suc-AAPF-pNA is a chromogenic substrate that can be cleaved by cathepsin G (K_m = 1.7 mM), subtilisins, chymotrypsin (K_m = 60 μM), chymase (K_m = 4 mM), and cyclophilin, but not neutrophil elastase. Release of p-nitroanilide is monitored at 405-410 nm. This substrate can be used for inhibitor screening and kinetic analysis.

Uses

N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide has been used as a substrate to determine chymotrypsin activity.

Biochem/physiol Actions

N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide is a substrate for subtilisin and proteases.

References

[1] K. NAKAJIMA. Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.[J]. The Journal of Biological Chemistry, 1979, 107 1: 4027-4032. DOI: 10.1016/s0021-9258(18)50690-6
[2] J ERMOLIEFF. Heparin protects cathepsin G against inhibition by protein proteinase inhibitors.[J]. The Journal of Biological Chemistry, 1994, 269 47: 29502-29508.
[3] JAMES L. KOFRON. Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay[J]. Biochemistry Biochemistry, 1991, 30 25: 6127-6134. DOI: 10.1021/bi00239a007
[4] H NAKAKUBO. Secretory production of recombinant human chymase as an active form in Pichia pastoris.[J]. Yeast, 2000, 16 4: 315-323. DOI: 10.1002/1097-0061(20000315)16:4<315::aid-yea527>3.0.co;2-4

SUC-ALA-ALA-PRO-PHE-PNA Preparation Products And Raw materials

Raw materials

Preparation Products

SUC-ALA-ALA-PRO-PHE-PNA Suppliers

Global( 122)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20582	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15083	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24597	58
Nanjing TGpeptide	+86-13347807150	support@tgpeptide.com	China	3279	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Changsha MOL Changes Biotechnology Co., Ltd.	+8619375158599	info@molchanges.com	China	5218	58
LEON (NANJING) BIOTECHNOLOGY CO., LTD.	+8615051830413	sales.njleonbiotech@gmail.com	China	5482	58

Supplier	Advantage
Shenzhen Nexconn Pharmatechs Ltd	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Zhejiang J&C Biological Technology Co.,Limited	58
Chengdu Youngshe Chemical Co., Ltd.	58
HANGZHOU LEAP CHEM CO., LTD.	58
Nanjing TGpeptide	58
Aladdin Scientific	58
Changsha MOL Changes Biotechnology Co., Ltd.	58
LEON (NANJING) BIOTECHNOLOGY CO., LTD.	58

SUC-ALA-ALA-PRO-PHE-PNA Spectrum

SUC-ALA-ALA-PRO-PHE-PNA(70967-97-4)¹HNMR

70967-97-4(SUC-ALA-ALA-PRO-PHE-PNA)Related Search:

SUC-ALA-ALA-ALA-PNA N,N'-Ethylenebis(stearamide) 5-METHYL-N,N-DIMETHYLTRYPTAMINE L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- EC 3.4.22.1

SUC-GLY-PHE-GLY-PNA CHYMOTRYPSIN SUBSTRATE I, COLORIMETRIC SUC-ALA-ALA-PRO-VAL-AMC Chymotrypsin Substrate II, Fluorogenic SUC-ALA-PRO-PNA

SUC-ALA-PHE-LYS-AMC SUC-PHE-PRO-PHE-PNA Suc-Phe-Gly-Leu-βNA SUC-PHE-ALA-ALA-PHE-PNA SUC-ALA-ALA-VAL-AMC

SUC-ALA-ALA-PRO-NVA-PNA SUC-VAL-PRO-PHE-SBZL SUC-PHE-LEU-PHE-SBZL

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N-Succinyl-Ala-Ala-Pro-Phe 4-nitroanilide succinyl-alanyl-alanyl-prolyl-phenylalanine-4-nitroanilide N-succinyl-alanyl-alanyl-prolyl-phenylanaline nitroanilide N-Succinyl-Ala-Ala-Pro-Phe-pNA, N-Succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide Cathepsin G Substrate I N-SUCCINYL-L-ALANYL-L-ALANYL-L-PROLYL-L-PHENYLALANINE 4-NITROANILIDE N-SUCCINYL-ALA-ALA-PRO-PHE-PNA N-SUCCINYL-ALA-ALA-PRO-PHE P-NITROANILIDE Succinyl-Ala-Ala-Pro-Phe-p-nitroanilide - CAS 70967-97-4 - Calbiochem SAAPNA N-Succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine p-nitroanilide Cathepsin G substrate CATHEPSIN G SUBSTRATE I, COLORIMETRIC SUCCINYL-L-ALANYL-L-ALANYL-L-PROLYL-L-PHENYLALANINE-4-NITROANILIDE SUCCINYL-ALA-ALA-PRO-PHE-P-NITROANILIDE SUC-ALA-ALA-PRO-PHE-PARANITROANILIDE SUC-ALA-ALA-PRO-PHE-PNA SUC-AAPF-PNA SUC-ALA-ALA-PRO-PHE-PNA USP/EP/BP 70967-97-4/107409-54-1 N-(3-carboxypropanoyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-L-phenylalaninamide Succinyl-Ala-Ala-Pro-Phe-p-nitroanilide L-Phenylalaninamide,N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)- 70967-97-4 C30H36N6O9 Chymotrypsin, alpha Enzyme Substrates Enzymes, Inhibitors, and Substrates Substrates Substrates by Enzyme Apoptosis and Cell Cycle Cathepsins and Granzymes Cathepsin G Cell Signaling and Neuroscience Cell Biology Biochemicals and Reagents BioChemical amino ADC Linker