Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Inflachromene

Inflachromene

Inflachromene Structure
Inflachromene structure
CAS No.
908568-01-4
Chemical Name:
Inflachromene
Synonyms
ICM;Inflachromene;Inflachromene (ICM);5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-1H,7H-[1]benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione;1H,7H-[1]Benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione, 5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-;5-hydroxy-9,9-dimethyl-15-phenyl-8-oxa-13,15,17-triazatetracyclo[8.7.0.02,7.013,17]heptadeca-2(7),3,5,10-tetraene-14,16-dione
CBNumber:
CB94200546
Molecular Formula:
C21H19N3O4
Molecular Weight:
377.39
MDL Number:
MFCD30719253
MOL File:
908568-01-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-10 08:17:50
Request For Quotation

Inflachromene Properties

Boiling point 532.6±60.0 °C(Predicted)
Density 1.50±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF:30.0(Max Conc. mg/mL);79.49(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);79.49(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.53(Max Conc. mM)
Ethanol:2.5(Max Conc. mg/mL);6.62(Max Conc. mM)
form A crystalline solid
pka 9.65±0.40(Predicted)
color White to yellow

Inflachromene price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17006 Inflachromene ≥95% 908568-01-4 5mg $147 2026-04-30 Buy
Cayman Chemical 17006 Inflachromene ≥95% 908568-01-4 10mg $234 2026-04-30 Buy
Cayman Chemical 17006 Inflachromene ≥95% 908568-01-4 25mg $543 2026-04-30 Buy
Biosynth ILB56801 Inflachromene 908568-01-4 10mg $762 2026-06-04 Buy
Biosynth ILB56801 Inflachromene 908568-01-4 25mg $1429 2026-06-04 Buy
Product number Packaging Price Buy
17006 5mg $147 Buy
17006 10mg $234 Buy
17006 25mg $543 Buy
ILB56801 10mg $762 Buy
ILB56801 25mg $1429 Buy

Inflachromene Chemical Properties, Uses, Production

Uses

Inflachromene is a novel microglial inhibitor, which binds to HMGB1 (High Mobility Group Box 1) and HMGB2 (High mobility Group Box 2) inhibiting microglia-mediated neuroinflammation.

in vivo

Inflachromene (2-10 mg/kg; i.p. once daily for 4 days) effectively blocks LPS-mediated microglial activation[2].
Inflachromene (10 mg/kg; i.p. once daily for 30 days) significantly reduces the progression of disease, as determined by EAE clinical score[2].
Inflachromene (1 mg/kg; i.v.) exhibits long half-life (14.1±6.43 h) and moderate Vss (2.02±1.02 L/kg)[1].
Inflachromene (1 mg/kg; p.o.) exhibits high oral bioavailability (94%) and Cmax (0.59±0.16 g/mL)[1].

Animal Model:Male C57BL/6 mice (11 weeks; 25-30 g) are treated with LPS[2]
Dosage:2, 10 mg/kg
Administration:I.p. once daily for 4 days
Result:Blocked LPS-mediated microglial activation, even at a dose of 2 mg/kg.
Animal Model:Sprague-Dawley (SD) rats (7 weeks; 230-250 g)[1]
Dosage:1 mg/kg (Pharmacokinetic Analysis)
Administration:I.v. and p.o. administration
Result:I.v.: t1/2=14.1±6.43 h; CL= 0.14±0.01 L/kg/h; Vss=2.02±1.02 L/kg.
P.o.: t1/2=7.96±1.16 h; F=94%; Cmax=0.59±0.16 g/mL.

Inflachromene Preparation Products And Raw materials

Raw materials

Preparation Products

Inflachromene Suppliers

Global Suppliers ( 30)
Supplier Tel Email Country ProdList Advantage
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 13816107857 sales@fortunechem-sh.com China 981 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai Changyan Chem & Tech Co., Ltd. 021-20242659 18930833303 sales@changyanchem.cn China 4998 55
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239 3193328036@qq.com China 28150 68
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Changzhou Chenhong Biotechnology Co., Ltd. +86-0519-85788828 +86-13775037613 sales@chemrenpharm.com China 4058 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4565 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10233 58
Supplier Advantage
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Changyan Chem & Tech Co., Ltd. 55
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Shanghai Hongye Biotechnology Co. Ltd 58
TargetMol Chemicals Inc. 58
Changzhou Chenhong Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
ShangHai ChuanQian Chemcial Technique Centre 58
cjbscvictory 58

View Latest Price from Inflachromene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Inflachromene pictures 2026-09-10 Inflachromene
908568-01-4
 $117.00-463.00 99.39% 10g TargetMol Chemicals Inc.
  • Inflachromene pictures
  • Inflachromene
    908568-01-4
  • $117.00-463.00
  • 99.39%
  • TargetMol Chemicals Inc.

908568-01-4 (Inflachromene) Related Search:

Green purple sweet potato red pigment Chicken color Buckwheat pigment Chocolate brown pigment Purple sweet potato red pigment
M8631-1G Melanin 1. Melanin in the skin lesions on the trunk MELANIN

1of2

Inflachromene Inflachromene (ICM) 5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-1H,7H-[1]benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione 1H,7H-[1]Benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione, 5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl- 5-hydroxy-9,9-dimethyl-15-phenyl-8-oxa-13,15,17-triazatetracyclo[8.7.0.02,7.013,17]heptadeca-2(7),3,5,10-tetraene-14,16-dione ICM 908568-01-4