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ChemicalBook >> CAS DataBase List >>Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate

Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate

Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate Structure
Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate structure
CAS No.
100123-25-9
Chemical Name:
Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate
Synonyms
Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate;5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER;Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate - [E37736];1H-Indole-2-carboxylic acid, 5-bromo-3-formyl-, ethyl ester
CBNumber:
CB9428546
Molecular Formula:
C12H10BrNO3
Molecular Weight:
296.12
MDL Number:
MFCD02257704
MOL File:
100123-25-9.mol
MSDS File:
SDS
Last updated:2026-09-12 18:56:28
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Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate Properties

Melting point 245 °C(Solv: ethanol (64-17-5))
Boiling point 476.7±45.0 °C(Predicted)
Density 1.608±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 12.56±0.30(Predicted)
Appearance Off-white to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 223080 Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate 100123-25-9 1.00g $370 2026-05-18 Buy
Matrix Scientific 223080 Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate 100123-25-9 5.00g $1294 2026-05-18 Buy
Synthonix E37736 Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate 98% 100123-25-9 250mg $44 2026-05-06 Buy
Synthonix E37736 Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate 98% 100123-25-9 1g $50 2026-05-06 Buy
Synthonix E37736 Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate 98% 100123-25-9 5g $240 2026-05-06 Buy
Product number Packaging Price Buy
223080 1.00g $370 Buy
223080 5.00g $1294 Buy
E37736 250mg $44 Buy
E37736 1g $50 Buy
E37736 5g $240 Buy

Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate Chemical Properties,Uses,Production

Uses

Ethyl 5-Bromo-3-formyl-1h-indole-2-carboxylate is a versatile building block. It was used as a reactant in the synthetic preparation of hydroxyindolecarboxylates by Baeyer-Villiger oxidation.

Synthesis

Ethyl 5-Bromoindole-2-carboxylate

16732-70-0

ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE

100123-25-9

Oxalyl chloride (3.43 mL, 39.9 mmol) was slowly added dropwise to a mixed solution containing DMF (30 mL) and dichloromethane (80 mL) at 0 °C while maintaining stirring. After the dropwise addition was completed, stirring was continued at 0 °C for 20 min. Subsequently, a solution of ethyl 5-bromoindole-2-carboxylate (10 g, 37.3 mmol) dissolved in DMF (80 mL) was added. The reaction mixture was transferred to room temperature and stirred continuously for 24 hours. Upon completion of the reaction, the mixture was poured into saturated aqueous sodium bicarbonate solution and extracted with dichloromethane. The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Finally, the target product ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate was obtained by ethanol recrystallization in a yield of 8.9 g and 81%.

References

[1] Patent: WO2006/77366, 2006, A1. Location in patent: Page/Page column 152
[2] Patent: WO2006/77367, 2006, A1. Location in patent: Page/Page column 89

Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate Preparation Products And Raw materials

Raw materials

Ethyl 5-Bromoindole-2-carboxylate Dichloromethane Oxalyl chloride

Preparation Products

Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate Suppliers

Global( 55)Suppliers
Supplier Tel Email Country ProdList Advantage
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai ChuangYan Chemical Technology Co., Ltd. 021-11111111 11111111111 546919421@qq.com China 3770 55
Shanghai Tombiopharma Chemical Co. Ltd. 13391076197 tombiopharma@163.com China 4986 55
JW & Y Pharmlab Co., Ltd. 021-64340559 xinyu_shi@jwypharmlab.com.cn China 11999 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Yantai ShengKailun Chemical Technology Co., Ltd. 13356901049 3119594100@qq.com China 7964 55
Shanghai Pingguo Pharmaceutical Co., Ltd. 021-20432229 2412110556@qq.com China 6016 55
Beijing YiboYuntian Technology Co., Ltd. 13811826434 lichen13811826434@126.com China 697 58
Aikon International Limited 025-58851090 13913916777 sales01@aikonchem.com China 15947 58
Supplier Advantage
Bide Pharmatech Ltd. 60
Shanghai ChuangYan Chemical Technology Co., Ltd. 55
Shanghai Tombiopharma Chemical Co. Ltd. 55
JW & Y Pharmlab Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Amadis Chemical Company Limited 58
Yantai ShengKailun Chemical Technology Co., Ltd. 55
Shanghai Pingguo Pharmaceutical Co., Ltd. 55
Beijing YiboYuntian Technology Co., Ltd. 58
Aikon International Limited 58

Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate Spectrum

ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE(100123-25-9)1HNMR

100123-25-9(Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate)Related Search:

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5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER 1H-Indole-2-carboxylic acid, 5-bromo-3-formyl-, ethyl ester Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate - [E37736] Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate 100123-25-9