Oxonic acid potassium salt
- CAS No.
- 2207-75-2
- Chemical Name:
- Oxonic acid potassium salt
- Synonyms
- OXO;OTERACIL POTASSIUM;POTASSIUM OXONATE;NOX4;Potassium otastat;oxonic acid potassium;kox;KOX-1;Anti-KOX-1;otassiuM oxonate
- CBNumber:
- CB9435346
- Molecular Formula:
- C4H2KN3O4
- Molecular Weight:
- 195.17
- MDL Number:
- MFCD00010565
- MOL File:
- 2207-75-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 300 °C(lit.) |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Aqueous Base (Slightly), Water (Slightly, Heated, Sonicated) |
| form | Powder |
| color | White |
| biological source | rabbit |
| Water Solubility | Soluble in hot water. |
| InChI | InChI=1S/C4H3N3O4.K/c8-2(9)1-5-3(10)7-4(11)6-1;/h(H,8,9)(H2,5,6,7,10,11);/q;+1/p-1 |
| InChIKey | IAPCTXZQXAVYNG-UHFFFAOYSA-M |
| SMILES | C1(C([O-])=O)=NC(NC(=O)N1)=O.[K+] |
| CAS DataBase Reference | 2207-75-2(CAS DataBase Reference) |
| FDA UNII | 4R7FFA00RX |
| UNSPSC Code | 12352203 |
| NACRES | NA.41 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | RR4580000 |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
Oxonic acid potassium salt price More Price(94)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 156124 | Oxonic acid potassium salt 97% | 2207-75-2 | 5g | $48.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | 156124 | Oxonic acid potassium salt 97% | 2207-75-2 | 25g | $233 | 2026-04-30 | Buy |
| Sigma-Aldrich | SAB5700950 | Anti- NOX4 antibody produced in rabbit | 100μL | $448 | 2026-04-30 | Buy | |
| Sigma-Aldrich | HPA015475 | Anti-NOX4 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 2207-75-2 | 25μL | $282 | 2023-06-20 | Buy |
| Sigma-Aldrich | SAB5700950 | Anti- NOX4 antibody produced in rabbit | 2207-75-2 | 100UL | $389 | 2023-06-20 | Buy |
Oxonic acid potassium salt Chemical Properties, Uses, Production
Description
Oxonic acid is a uricase inhibitor that prevents metabolism and excretion of uric acid and induces embryotoxicity and nephrotoxicity in rats. It is a component of S-1, a mixture containing a prodrug of the antitumor agent 5-fluorouracil (5-FU; ), that suppresses the gastrointestinal toxicity of 5-FU without inhibiting its antitumor activity in rats. Formulations containing oxonic acid have been used to treat gastric, pancreatic, lung, head, neck, and breast carcinomas.
Chemical Properties
Off-White Solid
Uses
Antitumor effect potentiator and antitumor agent
Uses
Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.
Definition
ChEBI: Potassium 2,6-dihydroxytriazinecarboxylate is an organic molecular entity.
Synthesis
64-19-7
97-59-6
2207-75-2
The general procedure for synthesizing potassium oxonate from glacial acetic acid and allantoin was as follows: 3.2 kg of potassium hydroxide was dissolved in 11.4 L of water, added to a 20 L reactor to dissolve, and then cooled to 0~5 °C. 46 g of potassium iodide was added, and 0.9 kg of allantoin was added in batches and stirred until completely dissolved, keeping the temperature at 0~5 °C. Subsequently, 1.8 kg of bromine was slowly added dropwise, and the dropwise time was controlled at 9 hours (the experiment was divided into the first 1-8 groups according to the difference of bromine dropwise time). After the dropwise addition was completed, stirring was continued at 0~5°C for 1 h. Then the temperature was increased to 20~25°C and the reaction was kept at this temperature for 20 h. The reaction was carried out by HPLC. After confirming that the allantoin content was less than 0.6% by HPLC, the reaction solution was cooled to 0~5°C. The pH was adjusted to 5 with acetic acid and the reaction solution was filtered. The filter cake was washed with 3 L of water at 0~5°C and then with 1 L of room temperature ethanol. Finally, potassium oxonate was allowed to precipitate from a white potassium oxide crystalline solid at room temperature.
in vivo
Potassium oxonate can be used in animal modeling to create hyperuricemia models. After metabolism, Potassium oxonate primarily distributes within the cells of the small intestine. In the gastrointestinal tract, Potassium oxonate is converted to cyanuric acid via two pathways: the first involves direct conversion by gut microbiota in the cecum, and the second involves conversion through xanthine oxidase, or after degradation by stomach acid into 5-aza-uracil (5-AZU), followed by conversion through aldehyde oxidase[3].
Administration: 300 mg/kg i.p. once daily for 14 days
(2) On day 15, the mice are fasted for 12 hours, anesthetized with pentobarbital sodium, and then all sacrificed.
(3) Collect mouse blood samples in 2mL EP tubes, centrifuge (3000rpm, 4°C, 10min), and then store at -80°C for biochemical determination.
(4) The kidney tissue is quickly removed, weighed and divided into two parts, one part was fixed in 4% paraformaldehyde for histopathological examination, and the other part is stored at -80°C for further biochemical determination.
Histological changes: Inconspicuous boundaries between adjacent proximal tubule cells, swelling and proximal tubule necrosis.
References
[1] Patent: CN106083750, 2016, A. Location in patent: Paragraph 0019; 0020; 0021
Oxonic acid potassium salt Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Sunshine Pharmaceutical Co.,Ltd. | 531-82812892 18668915976 | sales@sunshinepharm.com.cn | China | 28 | 58 |
| Jinan Zhongke Yitong Chemical Co., Ltd. | 0531-88658009 15552873609 | lxxcs@163.com | China | 96 | 58 |
| Jinan Londi Medical Technology Co., LTD | 0531-88996911 15628983711 | 3305202763@qq.com | China | 125 | 58 |
| Shandong Chenxi Pharmaceutical Co., Ltd. | +86-531-88803416 13153166250 | sales@chemedpharma.com | China | 149 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Latest Price from Oxonic acid potassium salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-15 | Oxonic acid potassium salt
2207-75-2
|
1kg | 99%min | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-15 | Potassium oxonate
2207-75-2
|
99.86% | 10g | TargetMol Chemicals Inc. | |||
 |
2026-07-15 | Oteracil Potassium
2207-75-2
|
1KG | 99% | 10Tons | Wuhan Fortuna Chemical Co.,Ltd |
-
- Oxonic acid potassium salt
2207-75-2
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Potassium oxonate
2207-75-2
- $0.00
- 99.86%
- TargetMol Chemicals Inc.
-
- Oteracil Potassium
2207-75-2
- $0.00
- 99%
- Wuhan Fortuna Chemical Co.,Ltd
