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Methylsulfonylacetonitrile

Methylsulfonylacetonitrile structure

CAS No.: 2274-42-2

Chemical Name:: Methylsulfonylacetonitrile

Synonyms: 2-(METHYLSULFONYL)ACETONITRILE;NSC 207832;CHEBI:32444;mesylacetonitrile;2-mesylacetonitrile;Methylsufonylacetonitrile;CYANOMETHYLSULFONYLMETHANE;Methylsulfonylacetonitrile;Cyanomethyl methyl sulphone;Methylsulphonylacetonitrile

CBNumber:: CB9435816

Molecular Formula:: C3H5NO2S

Molecular Weight:: 119.14

MDL Number:: MFCD00014743

MOL File:: 2274-42-2.mol

MSDS File:: SDS

Last updated:2026-09-12 18:56:28

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Methylsulfonylacetonitrile Properties

Melting point	81-84 °C(lit.)
Boiling point	360.6±25.0 °C(Predicted)
Density	1.288±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Powder or Crystalline Powder
color	White to off-white
Water Solubility	Slightly soluble in water.
BRN	969929
InChI	InChI=1S/C3H5NO2S/c1-7(5,6)3-2-4/h3H2,1H3
InChIKey	FOTRKCAZUSJCQD-UHFFFAOYSA-N
SMILES	C(#N)CS(C)(=O)=O
CAS DataBase Reference	2274-42-2(CAS DataBase Reference)
FDA UNII	H5U7X5ZYL7
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332

Precautionary statements

P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xn,T

Risk Statements

20/21/22

Safety Statements

22-26-36

RIDADR

UN 3439 6.1/PG 3

WGK Germany

HazardClass

6.1

PackingGroup

III

HS Code

2926907090

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral

Limited Quantities

5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
3		0

Methylsulfonylacetonitrile price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	184365	(Methylsulfonyl)acetonitrile 97%	2274-42-2	25g	$307	2026-04-30	Buy
TCI Chemical	M0667	Methylsulfonylacetonitrile >98.0%(GC)	2274-42-2	5g	$66	2026-04-30	Buy
TCI Chemical	M0667	Methylsulfonylacetonitrile >98.0%(GC)	2274-42-2	25g	$199	2026-04-30	Buy
Usbiological	283329	(Methanesulfonyl)acetonitrile Asreported	2274-42-2	10g	$400	2026-06-03	Buy
Usbiological	283329	(Methanesulfonyl)acetonitrile Asreported	2274-42-2	25g	$563	2026-06-03	Buy

Product number	Packaging	Price	Buy
184365	25g	$307	Buy
M0667	5g	$66	Buy
M0667	25g	$199	Buy
283329	10g	$400	Buy
283329	25g	$563	Buy

Methylsulfonylacetonitrile Chemical Properties, Uses, Production

Uses

Methylsulfonylacetonitrile is used in preparation of substituted pyrimidinylamino isoquinoline and naphthyridine compounds as inhibitors of mutant forms of EGFR.

Uses

(Methylsulfonyl)acetonitrile was used in the synthesis of:

substituted δ-pyrone ring analogues
4,9-dihydropyrrolo[2,1-b]quinazolines containing electron withdrawing groups at the 3-position

Definition

ChEBI: (methylsulfonyl)acetonitrile is an aliphatic nitrile.

Methylsulfonylacetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

3-Ethoxy-4-Methoxy-alpha-[(Methylsulfonyl)Methyl]-benzeneMethanaMine 2-methyl-2-(methylsulfonyl)propanenitrile

Methylsulfonylacetonitrile Suppliers

Global Suppliers ( 129)

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Copiore Chemical Co., Ltd.	17300981287 13757145729	sales@copiore.com	China	291	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64

Supplier	Advantage
Hangzhou Copiore Chemical Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Beijing Ouhe Technology Co., Ltd	60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64

View Latest Price from Methylsulfonylacetonitrile manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	METHYLSULFONYLACETONITRILE 2274-42-2	$8.80	1KG	97%-99%	100kg	Career Henan Chemical Co

METHYLSULFONYLACETONITRILE
2274-42-2
$8.80
97%-99%
Career Henan Chemical Co

Methylsulfonylacetonitrile Spectrum

METHYLSULFONYLACETONITRILE(2274-42-2)MS METHYLSULFONYLACETONITRILE(2274-42-2)¹HNMR METHYLSULFONYLACETONITRILE(2274-42-2)¹³CNMR METHYLSULFONYLACETONITRILE(2274-42-2)IR1 METHYLSULFONYLACETONITRILE(2274-42-2)IR2

2274-42-2 (Methylsulfonylacetonitrile) Related Search:

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Methylsulphonylacetonitrile mesylacetonitrile 2-(Methylsulphonyl)acetonitrile Methanesulfonylacetonitrile,98+% Methanesulphonylacetonitrile,98+% Methylsulfonylacetonitrile, 98+% Methylsufonylacetonitrile Cyanomethyl methyl sulphone Cyanomethylsulfonylmethane Methanesulfonylacetonitrile Cyanomethyl methyl sulphone, 2-(Methylsulphonyl)ethanonitrile 2-Methanesulfonylacetonitrile 2-mesylacetonitrile 2-methylsulfonylethanenitrile CHEBI:32444 NSC 207832 METHANESULPHONYLACETONITRILE METHANESULFONYLACETONITRILE Acetonitrile, (methylsulfonyl)- CYANOMETHYLSULFONYLMETHANE Methylsulfonylacetonitrile> Acetonitrile, 2-(methylsulfonyl)- 2-(METHYLSULFONYL)ACETONITRILE Methylsulfonylacetonitrile 2274-42-2 2274-42-4 C3H5NO2S 3H5NO2S CH3SO2CH2CN Building Blocks C1 to C5 Organic Building Blocks Nitrogen Compounds Cyanides/Nitriles Aliphatics C1 to C5 Cyanides/Nitriles Nitrogen Compounds