BRYOSTATIN 1
- CAS No.
- 83314-01-6
- Chemical Name:
- BRYOSTATIN 1
- Synonyms
- BRYOSTATIN;BRYO 1;CS-1164;NSC-339555;Byrostatin 1;BRYOSTATIN 1;bryostatin1,0;(26R)-Bryostatin 1;Bryostatin 1, protein kinase C activator;Bryostatin 1 - CAS 83314-01-6 - Calbiochem
- CBNumber:
- CB9454936
- Molecular Formula:
- C47H68O17
- Molecular Weight:
- 905.03
- MDL Number:
- MFCD00893832
- MOL File:
- 83314-01-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 230-235° |
|---|---|
| alpha | D25 +34.1° (c = 0.044 in methanol) |
| Boiling point | 716.44°C (rough estimate) |
| Density | 1.1245 (rough estimate) |
| refractive index | 1.5940 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| form | solid |
| pka | 11.10±0.70(Predicted) |
| color | white |
| optical activity | +34.125 (methanol) |
| InChIKey | MJQUEDHRCUIRLF-TVIXENOKSA-N |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | bryostatin 1 |
| FDA UNII | 37O2X55Y9E |
| NCI Drug Dictionary | bryostatin 1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335-H373 |
| Precautionary statements | P271-P280-P312 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | Xn |
| Risk Statements | 68 |
| Safety Statements | 22-24/25-36/37 |
| WGK Germany | 3 |
| RTECS | EH9455000 |
| HS Code | 2932990090 |
| Storage Class | 11 - Combustible Solids |
| Toxicity | LD50 in mice, rats (mg/kg): 0.038, 0.068 i.v. (Prendiville) |
BRYOSTATIN 1 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B7431 | Bryostatin 1 ≥99%, solid | 83314-01-6 | 10μg | $252 | 2026-04-30 | Buy |
| Sigma-Aldrich | 203811 | Bryostatin 1 - CAS 83314-01-6 - Calbiochem A macrocyclic lactone with antitumor properties. | 83314-01-6 | 10μG | $271 | 2026-04-30 | Buy |
| Cayman Chemical | 14802 | Bryostatin 1 ≥98% | 83314-01-6 | 10μg | $655 | 2026-04-30 | Buy |
| Usbiological | B2902-50 | Bryostatin 1 (NSC 339555, B705008K112, BRN 4349157) | 83314-01-6 | 10ug | $785 | 2026-06-03 | Buy |
| Biosynth | IDA31401 | Bryostatin 1 | 83314-01-6 | 10ug | $649 | 2026-06-04 | Buy |
BRYOSTATIN 1 Chemical Properties, Uses, Production
Uses
Bryostatin 1 has been used to study its effects on spontaneous Crohn′s disease (CD) like colitis inmice. It has also been used to study its effects as an anthelmintic drug on adult Syphacia muris infection in rats.
Definition
ChEBI: A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoe hylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of br ostatins.
Biological Activity
Protein kinase C (PKC) activator that binds with high affinity (K i = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents.
Biochem/physiol Actions
Bryostatin 1 (Bry1) is a macrocyclic lactone. This synaptogenic compound is obtained from the marine bryozoanBugula neritina. Bry1 is capable of reversing synaptic loss. It can enable synaptic maturation in animal models with several neurological disorders. It possesses antidepressant activity, when administered intracebroventricularly. Bry1 is known to participate in protecting cell tight junctions (TJs), anti-inflammatory functions and immune regulation.
storage
Store at -20°C
References
[1]. gschwendt m, fürstenberger g, rose-john s, et al. bryostatin 1, an activator of protein kinase c, mimics as well as inhibits biological effects of the phorbol ester tpa in vivo and in vitro. carcinogenesis, 1988, 9(4): 555-562.
[2]. stone rm, sariban e, pettit gr, et al. bryostatin 1 activates protein kinase c and induces monocytic differentiation of hl-60 cells. blood, 1988, 72(1): 208-213.
[3]. schuchter lm, esa ah, may s, et al. successful treatment of murine melanoma with bryostatin 1. cancer res, 1991, 51(2): 682-687.
BRYOSTATIN 1 Preparation Products And Raw materials
Raw materials
Preparation Products
BRYOSTATIN 1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-84699383-8003;025-846993838003-8003 18013301590 | njduly@126.com | China | 3293 | 55 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 18080489829@163.com | China | 8379 | 60 |
View Latest Price from BRYOSTATIN 1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Bryostatin 1
83314-01-6
|
$859.00 | 10g | TargetMol Chemicals Inc. |
-
- Bryostatin 1
83314-01-6
- $859.00
- TargetMol Chemicals Inc.
83314-01-6 (BRYOSTATIN 1) Related Search:
1of4
